The magnitude and predictors of abandonment of therapy in paediatric acute leukaemia in middle-income countries

A systematic review and meta-analysis

Sumit Gupta, Stacy Yeh, Alexandra Martiniuk, Catherine G. Lam, Heui Yang Chen, Yen Lin Liu, Argerie Tsimicalis, Ramandeep S. Arora, Raul C. Ribeiro

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Background Abandonment of therapy is a significant cause of paediatric cancer treatment failure in low- to middle-income countries (LMIC), but its impact has been underestimated. We performed a meta-analysis to determine the magnitude of abandonment in paediatric leukaemia in LMIC and sought to identify patient-, centre- and country-specific predictors of abandonment. Patients and Methods We searched seven databases to identify paediatric oncology cohorts followed up from diagnosis and treated in LMIC. All languages were included. Two reviewers independently selected articles and extracted data. Authors were contacted for additional information. Subgroup analyses were planned a priori. Results Of 22,384 publications, 318 in eight languages met criteria for full text review. 157 studies met analysis inclusion criteria. Abandonment rates (ARs), obtained for 83 of the 157 studies (52.9%), ranged from 0% to 74.5%. ARs were frequently unreported and available only directly from authors. Forty studies (10,494 children in 20 countries) were quantitatively analysed. ARs for acute lymphoblastic laeukemia in lower-middle-income countries (lower-MICs) were higher than in upper-middle-income countries (29%, 95% confidence interval (CI) 23-36% versus 2%, 95% CI 1-3%; p < 0.0001) but were heterogeneous (I 2 = 98%; p < 0.0001). This heterogeneity was not explained by centre-specific (free versus paid treatment) or country-specific (government health expenditure, per-capital income) subgroups. Conclusions In LMICs, ARs are highest in lower-MICs. However, their broad range suggests that low ARs are possible in resource-constrained settings. Analysis of outliers may suggest interventions for use at other centres. Methodologically appropriate reporting of ARs should be adopted. Future research should evaluate interventions targeting abandonment.

Original languageEnglish
Pages (from-to)2555-2564
Number of pages10
JournalEuropean Journal of Cancer
Volume49
Issue number11
DOIs
Publication statusPublished - Jul 2013
Externally publishedYes

Fingerprint

Meta-Analysis
Leukemia
Pediatrics
Therapeutics
Language
Confidence Intervals
Health Expenditures
Treatment Failure
Publications
Economics
Databases
Neoplasms

Keywords

  • Abandonment
  • Child
  • Developing countries
  • Leukaemia
  • Meta-analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The magnitude and predictors of abandonment of therapy in paediatric acute leukaemia in middle-income countries : A systematic review and meta-analysis. / Gupta, Sumit; Yeh, Stacy; Martiniuk, Alexandra; Lam, Catherine G.; Chen, Heui Yang; Liu, Yen Lin; Tsimicalis, Argerie; Arora, Ramandeep S.; Ribeiro, Raul C.

In: European Journal of Cancer, Vol. 49, No. 11, 07.2013, p. 2555-2564.

Research output: Contribution to journalReview article

Gupta, Sumit ; Yeh, Stacy ; Martiniuk, Alexandra ; Lam, Catherine G. ; Chen, Heui Yang ; Liu, Yen Lin ; Tsimicalis, Argerie ; Arora, Ramandeep S. ; Ribeiro, Raul C. / The magnitude and predictors of abandonment of therapy in paediatric acute leukaemia in middle-income countries : A systematic review and meta-analysis. In: European Journal of Cancer. 2013 ; Vol. 49, No. 11. pp. 2555-2564.
@article{6d43a7a739c349d59d0c42b4fbe16ba7,
title = "The magnitude and predictors of abandonment of therapy in paediatric acute leukaemia in middle-income countries: A systematic review and meta-analysis",
abstract = "Background Abandonment of therapy is a significant cause of paediatric cancer treatment failure in low- to middle-income countries (LMIC), but its impact has been underestimated. We performed a meta-analysis to determine the magnitude of abandonment in paediatric leukaemia in LMIC and sought to identify patient-, centre- and country-specific predictors of abandonment. Patients and Methods We searched seven databases to identify paediatric oncology cohorts followed up from diagnosis and treated in LMIC. All languages were included. Two reviewers independently selected articles and extracted data. Authors were contacted for additional information. Subgroup analyses were planned a priori. Results Of 22,384 publications, 318 in eight languages met criteria for full text review. 157 studies met analysis inclusion criteria. Abandonment rates (ARs), obtained for 83 of the 157 studies (52.9{\%}), ranged from 0{\%} to 74.5{\%}. ARs were frequently unreported and available only directly from authors. Forty studies (10,494 children in 20 countries) were quantitatively analysed. ARs for acute lymphoblastic laeukemia in lower-middle-income countries (lower-MICs) were higher than in upper-middle-income countries (29{\%}, 95{\%} confidence interval (CI) 23-36{\%} versus 2{\%}, 95{\%} CI 1-3{\%}; p < 0.0001) but were heterogeneous (I 2 = 98{\%}; p < 0.0001). This heterogeneity was not explained by centre-specific (free versus paid treatment) or country-specific (government health expenditure, per-capital income) subgroups. Conclusions In LMICs, ARs are highest in lower-MICs. However, their broad range suggests that low ARs are possible in resource-constrained settings. Analysis of outliers may suggest interventions for use at other centres. Methodologically appropriate reporting of ARs should be adopted. Future research should evaluate interventions targeting abandonment.",
keywords = "Abandonment, Child, Developing countries, Leukaemia, Meta-analysis",
author = "Sumit Gupta and Stacy Yeh and Alexandra Martiniuk and Lam, {Catherine G.} and Chen, {Heui Yang} and Liu, {Yen Lin} and Argerie Tsimicalis and Arora, {Ramandeep S.} and Ribeiro, {Raul C.}",
year = "2013",
month = "7",
doi = "10.1016/j.ejca.2013.03.024",
language = "English",
volume = "49",
pages = "2555--2564",
journal = "European Journal of Cancer",
issn = "0959-8049",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - The magnitude and predictors of abandonment of therapy in paediatric acute leukaemia in middle-income countries

T2 - A systematic review and meta-analysis

AU - Gupta, Sumit

AU - Yeh, Stacy

AU - Martiniuk, Alexandra

AU - Lam, Catherine G.

AU - Chen, Heui Yang

AU - Liu, Yen Lin

AU - Tsimicalis, Argerie

AU - Arora, Ramandeep S.

AU - Ribeiro, Raul C.

PY - 2013/7

Y1 - 2013/7

N2 - Background Abandonment of therapy is a significant cause of paediatric cancer treatment failure in low- to middle-income countries (LMIC), but its impact has been underestimated. We performed a meta-analysis to determine the magnitude of abandonment in paediatric leukaemia in LMIC and sought to identify patient-, centre- and country-specific predictors of abandonment. Patients and Methods We searched seven databases to identify paediatric oncology cohorts followed up from diagnosis and treated in LMIC. All languages were included. Two reviewers independently selected articles and extracted data. Authors were contacted for additional information. Subgroup analyses were planned a priori. Results Of 22,384 publications, 318 in eight languages met criteria for full text review. 157 studies met analysis inclusion criteria. Abandonment rates (ARs), obtained for 83 of the 157 studies (52.9%), ranged from 0% to 74.5%. ARs were frequently unreported and available only directly from authors. Forty studies (10,494 children in 20 countries) were quantitatively analysed. ARs for acute lymphoblastic laeukemia in lower-middle-income countries (lower-MICs) were higher than in upper-middle-income countries (29%, 95% confidence interval (CI) 23-36% versus 2%, 95% CI 1-3%; p < 0.0001) but were heterogeneous (I 2 = 98%; p < 0.0001). This heterogeneity was not explained by centre-specific (free versus paid treatment) or country-specific (government health expenditure, per-capital income) subgroups. Conclusions In LMICs, ARs are highest in lower-MICs. However, their broad range suggests that low ARs are possible in resource-constrained settings. Analysis of outliers may suggest interventions for use at other centres. Methodologically appropriate reporting of ARs should be adopted. Future research should evaluate interventions targeting abandonment.

AB - Background Abandonment of therapy is a significant cause of paediatric cancer treatment failure in low- to middle-income countries (LMIC), but its impact has been underestimated. We performed a meta-analysis to determine the magnitude of abandonment in paediatric leukaemia in LMIC and sought to identify patient-, centre- and country-specific predictors of abandonment. Patients and Methods We searched seven databases to identify paediatric oncology cohorts followed up from diagnosis and treated in LMIC. All languages were included. Two reviewers independently selected articles and extracted data. Authors were contacted for additional information. Subgroup analyses were planned a priori. Results Of 22,384 publications, 318 in eight languages met criteria for full text review. 157 studies met analysis inclusion criteria. Abandonment rates (ARs), obtained for 83 of the 157 studies (52.9%), ranged from 0% to 74.5%. ARs were frequently unreported and available only directly from authors. Forty studies (10,494 children in 20 countries) were quantitatively analysed. ARs for acute lymphoblastic laeukemia in lower-middle-income countries (lower-MICs) were higher than in upper-middle-income countries (29%, 95% confidence interval (CI) 23-36% versus 2%, 95% CI 1-3%; p < 0.0001) but were heterogeneous (I 2 = 98%; p < 0.0001). This heterogeneity was not explained by centre-specific (free versus paid treatment) or country-specific (government health expenditure, per-capital income) subgroups. Conclusions In LMICs, ARs are highest in lower-MICs. However, their broad range suggests that low ARs are possible in resource-constrained settings. Analysis of outliers may suggest interventions for use at other centres. Methodologically appropriate reporting of ARs should be adopted. Future research should evaluate interventions targeting abandonment.

KW - Abandonment

KW - Child

KW - Developing countries

KW - Leukaemia

KW - Meta-analysis

UR - http://www.scopus.com/inward/record.url?scp=84879322035&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879322035&partnerID=8YFLogxK

U2 - 10.1016/j.ejca.2013.03.024

DO - 10.1016/j.ejca.2013.03.024

M3 - Review article

VL - 49

SP - 2555

EP - 2564

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

IS - 11

ER -