The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock

Jihwan Myung, Mei Yi Wu, Chun Ya Lee, Amalia Ridla Rahim, Vuong Hung Truong, Dean Wu, Hugh David Piggins, Mai Szu Wu

Research output: Contribution to journalArticle

Abstract

The kidney harbors one of the strongest circadian clocks in the body. Kidney failure has long been known to cause circadian sleep disturbances. Using an adenine-induced model of chronic kidney disease (CKD) in mice, we probe the possibility that such sleep disturbances originate from aberrant circadian rhythms in kidney. Under the CKD condition, mice developed unstable behavioral circadian rhythms. When observed in isolation in vitro, the pacing of the master clock, the suprachiasmatic nucleus (SCN), remained uncompromised, while the kidney clock became a less robust circadian oscillator with a longer period. We find this analogous to the silencing of a strong slave clock in the brain, the choroid plexus, which alters the pacing of the SCN. We propose that the kidney also contributes to overall circadian timekeeping at the whole-body level, through bottom-up feedback in the hierarchical structure of the mammalian circadian clocks.

Original languageEnglish
Article number2765
JournalInternational Journal of Molecular Sciences
Volume20
Issue number11
DOIs
Publication statusPublished - Jun 1 2019

Fingerprint

Circadian Clocks
kidneys
clocks
Clocks
Kidney
kidney diseases
circadian rhythms
Suprachiasmatic Nucleus
Circadian Rhythm
sleep
Chronic Renal Insufficiency
Sleep
Slaves
mice
disturbances
Choroid Plexus
Adenine
nuclei
harbors
Renal Insufficiency

Keywords

  • CKD
  • Circadian clocks
  • Hierarchical organization
  • Kidney
  • SCN
  • Systemic clocks

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock. / Myung, Jihwan; Wu, Mei Yi; Lee, Chun Ya; Rahim, Amalia Ridla; Truong, Vuong Hung; Wu, Dean; Piggins, Hugh David; Wu, Mai Szu.

In: International Journal of Molecular Sciences, Vol. 20, No. 11, 2765, 01.06.2019.

Research output: Contribution to journalArticle

Myung, Jihwan ; Wu, Mei Yi ; Lee, Chun Ya ; Rahim, Amalia Ridla ; Truong, Vuong Hung ; Wu, Dean ; Piggins, Hugh David ; Wu, Mai Szu. / The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock. In: International Journal of Molecular Sciences. 2019 ; Vol. 20, No. 11.
@article{c0e05dac825d4d45ba5741caa36d99e0,
title = "The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock",
abstract = "The kidney harbors one of the strongest circadian clocks in the body. Kidney failure has long been known to cause circadian sleep disturbances. Using an adenine-induced model of chronic kidney disease (CKD) in mice, we probe the possibility that such sleep disturbances originate from aberrant circadian rhythms in kidney. Under the CKD condition, mice developed unstable behavioral circadian rhythms. When observed in isolation in vitro, the pacing of the master clock, the suprachiasmatic nucleus (SCN), remained uncompromised, while the kidney clock became a less robust circadian oscillator with a longer period. We find this analogous to the silencing of a strong slave clock in the brain, the choroid plexus, which alters the pacing of the SCN. We propose that the kidney also contributes to overall circadian timekeeping at the whole-body level, through bottom-up feedback in the hierarchical structure of the mammalian circadian clocks.",
keywords = "CKD, Circadian clocks, Hierarchical organization, Kidney, SCN, Systemic clocks",
author = "Jihwan Myung and Wu, {Mei Yi} and Lee, {Chun Ya} and Rahim, {Amalia Ridla} and Truong, {Vuong Hung} and Dean Wu and Piggins, {Hugh David} and Wu, {Mai Szu}",
year = "2019",
month = "6",
day = "1",
doi = "10.3390/ijms20112765",
language = "English",
volume = "20",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",
number = "11",

}

TY - JOUR

T1 - The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock

AU - Myung, Jihwan

AU - Wu, Mei Yi

AU - Lee, Chun Ya

AU - Rahim, Amalia Ridla

AU - Truong, Vuong Hung

AU - Wu, Dean

AU - Piggins, Hugh David

AU - Wu, Mai Szu

PY - 2019/6/1

Y1 - 2019/6/1

N2 - The kidney harbors one of the strongest circadian clocks in the body. Kidney failure has long been known to cause circadian sleep disturbances. Using an adenine-induced model of chronic kidney disease (CKD) in mice, we probe the possibility that such sleep disturbances originate from aberrant circadian rhythms in kidney. Under the CKD condition, mice developed unstable behavioral circadian rhythms. When observed in isolation in vitro, the pacing of the master clock, the suprachiasmatic nucleus (SCN), remained uncompromised, while the kidney clock became a less robust circadian oscillator with a longer period. We find this analogous to the silencing of a strong slave clock in the brain, the choroid plexus, which alters the pacing of the SCN. We propose that the kidney also contributes to overall circadian timekeeping at the whole-body level, through bottom-up feedback in the hierarchical structure of the mammalian circadian clocks.

AB - The kidney harbors one of the strongest circadian clocks in the body. Kidney failure has long been known to cause circadian sleep disturbances. Using an adenine-induced model of chronic kidney disease (CKD) in mice, we probe the possibility that such sleep disturbances originate from aberrant circadian rhythms in kidney. Under the CKD condition, mice developed unstable behavioral circadian rhythms. When observed in isolation in vitro, the pacing of the master clock, the suprachiasmatic nucleus (SCN), remained uncompromised, while the kidney clock became a less robust circadian oscillator with a longer period. We find this analogous to the silencing of a strong slave clock in the brain, the choroid plexus, which alters the pacing of the SCN. We propose that the kidney also contributes to overall circadian timekeeping at the whole-body level, through bottom-up feedback in the hierarchical structure of the mammalian circadian clocks.

KW - CKD

KW - Circadian clocks

KW - Hierarchical organization

KW - Kidney

KW - SCN

KW - Systemic clocks

UR - http://www.scopus.com/inward/record.url?scp=85068175637&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068175637&partnerID=8YFLogxK

U2 - 10.3390/ijms20112765

DO - 10.3390/ijms20112765

M3 - Article

C2 - 31195684

AN - SCOPUS:85068175637

VL - 20

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 11

M1 - 2765

ER -