The joint effects of arsenic exposure, cigarette smoking and TNF-alpha polymorphism on urothelial carcinoma risk

C. C. Wu, Y. H. Wang, Y. M. Hsueh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The aim of the present study is to investigate the combined effects of urinary total arsenic level, cigarette smoking and secondhand smoke on Urothelial Carcinoma (UC) risk. We conducted a hospital-based case-control study consisting of 584 UC cases and 1098 cancer-free controls and found that ever smokers who exposed to secondhand smoke and carried the G/A and A/A genotypes of the TNF-α -308 G/A polymorphism had a significantly higher UC risk (OR = 5.17, 95% CI = 2.26–11.86). Ever smokers who exposed to higher total arsenic level (≥ 16.38 μg/g creatinine) and secondhand smoke had a significantly increased UC risk (OR = 13.18, 95% CI = 6.48–26.83). In conclusion, our findings suggest that the joint effects of urinary total arsenic level, cigarette smoking, secondhand smoke and the TNF-α -308 G/A and A/A genotypes on UC risk were statistically significant and showed a dose-response relationship.

Original languageEnglish
Title of host publicationArsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
EditorsProsun Bhattacharya, Gunnar Jacks, Jochen Bundschuh, Prosun Bhattacharya, Marie Vahter, Jerker Jarsjo, Jerker Jarsjo, Jurate Kumpiene, Arslan Ahmad, Charlotte Sparrenbom, Marinus Eric Donselaar, Jochen Bundschuh, Ravi Naidu, Ravi Naidu
PublisherCRC Press/Balkema
Pages359-360
Number of pages2
ISBN (Print)9781138029415
DOIs
Publication statusPublished - 2016
Event6th International Congress on Arsenic in the Environment, AS 2016 - Stockholm, Sweden
Duration: Jun 19 2016Jun 23 2016

Publication series

NameArsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016

Conference

Conference6th International Congress on Arsenic in the Environment, AS 2016
CountrySweden
CityStockholm
Period6/19/166/23/16

ASJC Scopus subject areas

  • Pollution
  • Environmental Chemistry

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