The joint effect of interleukin-12B rs3212227 genotype and behavioral factors on oral cancer risk in Taiwanese

Ching Hao Li, Kuo Ting Sun, Xin Li, Liang Chun Shih, Liang Yu Chen, Chien Chih Yu, Yun Chi Wang, Wen Shin Chang, Chia Wen Tsai, Chi Yuan Li, Da Tian Bau

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background/Aim: Oral cancer is of the highest incidence worldwide in Taiwan, and a better marker for personalized therapeutic strategies such as immunotherapies is urgently needed. Interleukin-12 (IL12) is a cytokine that has been reported to exhibit potent tumoricidal effects, however, its genotypic contribution to oral cancer is still largely unknown. The current study aimed at investigating whether IL12B rs3212227 genotype is associated with oral cancer in Taiwan. Materials and Methods: Genotypic characteristics of IL12B rs3212227 were determined among 958 oral cancer cases and age- and gender-matched individuals via typical polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) methodology. Results: The AA, AC and CC genotypes of IL12B rs3212227 were 38.2, 38.9 and 22.9% in the case group and 36.2, 41.5 and 22.3% in the control group (p=0.5189), respectively. Conclusion: IL12B rs3212227 genotype was associated with oral cancer risk only in betel quid chewers.

Original languageEnglish
Pages (from-to)6515-6521
Number of pages7
JournalAnticancer Research
Volume39
Issue number12
DOIs
Publication statusPublished - 2019

Keywords

  • Alcohol drinking
  • Betel quid
  • Genotype
  • Interleukin-12B
  • Oral cancer
  • Polymorphism
  • Smoking
  • Taiwan

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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