The intracranial volume pressure response in increased intracranial pressure patients: Part 1. Calculation of the volume pressure indicator

Hung Yi Lai, Ching Yi Lee, Hsun Hui Hsu, Shih Tseng Lee

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4 Citations (Scopus)


Background The intracranial pressure (ICP) is usually continuously monitored in the management of patients with increased ICP. The aim of this study was to discover a mathematic equation to express the intracranial pressure- volume (P-V) curve and a single indicator to reflect the status of the curve. Methods Patients with severe brain damage who had bilateral external ventricular drainage (EVD) from December 2008 to February 2010 were included in this study. The EVD was used as drainage of CSF and ICP monitor. The successive volume pressure response [6] values were obtained by successive drainage of CSF from ICP 20-25 to 10 mmHg. Parabolic, exponential, and linear regression models were designed to have a single parameter as the indicator to determine the P-V curves. Results The mean of parameter "a" in the exponential equation is 1.473±0.054; in the parabolic equation, it is 0.332±0.061; and in the linear equation, it is 1.717±0.209. All regression equations of P-V curves had statistical significance (p

Original languageEnglish
Pages (from-to)2271-2275
Number of pages5
JournalActa Neurochirurgica
Issue number12
Publication statusPublished - Dec 2012



  • Intracranial pressure
  • Mathematical model
  • Pressure-volume curve
  • Pressure-volume relationship
  • Volume pressure response

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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