The influence of liposomal adjuvant on intranasal vaccination of chickens against Newcastle disease

Li Ping Tseng, Hong Jen Liang, Ming Chung Deng, Kuo Ming Lee, Ryh Nan Pan, Jen Chang Yang, Yi You Huang, Der Zen Liu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The adjuvant effect of liposomes formulated with three phospholipids including phosphatidylcholine-liposomes (PC-Lip), phosphatidylserine-liposomes (PS-Lip), and stearylamine-liposomes (SA-Lip) was compared with virus alone using inactivated Newcastle disease virus (NDV) as a model antigen. The difference in adjuvanticity was evaluated using the haemagglutination-inhibition (HI) test, enzyme-linked immunosorbent assay, and a challenge study following intranasal inoculation of specific pathogen-free chickens.After two inoculations, a liposomal vaccine consisting of NDV in PC-Lip resulted in a significant increase in HI titre, up to 32-fold higher than a vaccine containing virus alone and 320-fold higher than a vaccine containing NDV in SA-Lip. PC-Lip also elicited a significant mucosal secretary immunoglobulin A response (P

Original languageEnglish
Pages (from-to)204-210
Number of pages7
JournalVeterinary Journal
Volume185
Issue number2
DOIs
Publication statusPublished - Aug 2010

Keywords

  • Adjuvant
  • Intranasal
  • Liposome
  • Newcastle disease virus
  • S-IgA

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)
  • Medicine(all)

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