The influence of cosolvents on the in-vitro percutaneous penetration of diclofenac sodium from a gel system

H. O. Ho, F. C. Huang, T. D. Sokoloski, M. T. Sheu

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The influence of cosolvents on the in-vitro percutaneous penetration of diclofenac sodium from a gel system was studied using a simplex lattice experimental design. Gel formulations were prepared by gelling the vehicle mixture of water, alcohol and propylene glycol with Carbomer 940. The synthetic membrane Durapore and hairless mouse skin were employed as barriers in a Franz-type diffusion cell. It was found that the penetration through the synthetic membrane was well described by the Higuchi model. There existed a better inverse relationship between the penetration rate and the drug solubility in the respective vehicle. It appeared to be a membrane-controlled mechanism when using hairless mouse skin as the barrier. The penetration rates in steady-state for nine formulations were fitted to a polynomial equation based on this simplex lattice method. A three-dimensional plot was constructed in this simplex surface studied. The maximal penetration rate was found to be from the vehicle containing water and ethanol in an exact volume ratio of 3:1 and the minimal penetration rate was observed from the vehicle containing water only.

Original languageEnglish
Pages (from-to)636-642
Number of pages7
JournalJournal of Pharmacy and Pharmacology
Volume46
Issue number8
Publication statusPublished - 1994

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Diclofenac
Hairless Mouse
carbopol 940
Gels
Membranes
Water
Skin
Solubility
Research Design
Ethanol
Pharmaceutical Preparations
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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The influence of cosolvents on the in-vitro percutaneous penetration of diclofenac sodium from a gel system. / Ho, H. O.; Huang, F. C.; Sokoloski, T. D.; Sheu, M. T.

In: Journal of Pharmacy and Pharmacology, Vol. 46, No. 8, 1994, p. 636-642.

Research output: Contribution to journalArticle

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