The Inducible Role of Ambient Particulate Matter in Cancer Progression via Oxidative Stress-Mediated Reactive Oxygen Species Pathways: A Recent Perception

Chiang-Wen Lee, Thi Thuy Tien Vo, Ching-Zong Wu, Miao-Ching Chi, Chieh-Mo Lin, Mei-Ling Fang, I-Ta Lee

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Cancer is one of the leading causes of premature death and overall death in the world. On the other hand, fine particulate matter, which is less than 2.5 microns in aerodynamic diameter, is a global health problem due to its small diameter but high toxicity. Accumulating evidence has demonstrated the positive associations between this pollutant with both lung and non-lung cancer processes. However, the underlying mechanisms are yet to be elucidated. The present review summarizes and analyzes the most recent findings on the relationship between fine particulate matter and various types of cancer along with the oxidative stress mechanisms as its possible carcinogenic mechanisms. Also, promising antioxidant therapies against cancer induced by this poison factor are discussed.
Original languageEnglish
Article number2505
Pages (from-to)1-21
Number of pages21
JournalCancers
Volume12
Issue number9
DOIs
Publication statusPublished - Sep 3 2020

Keywords

  • Antioxidant
  • Cancer
  • Carbon monoxide releasing molecules
  • Oxidative stress
  • Particulate matter
  • Redox signaling pathways

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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