The in Vivo Radiosensitizing Effect of Magnolol on Tumor Growth of Hepatocellular Carcinoma

Yu Shan Chen, Rou Sun, Wei Lung Chen, Yu Chen Yau, Fei Ting Hsu, Jing Gung Chung, Chia Jung Tsai, Chia Ling Hsieh, Ying Ming Chiu, Jiann Hwa Chen

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Background/Aim: Radiation (RT) induced ERK/NF-?B in hepatocellular carcinoma (HCC) has been reported in our previous works; it weakens the toxicity of RT or triggers a radioresistance effect. Thus, combining RT with a suitable NF-?B inhibitor may sensitize HCC to RT. Magnolol, a bioactive compound, was known to have antiinflammatory and anti-tumor functions. Here, we aimed to investigate whether magnolol may enhance anti-HCC efficacy of RT in vivo. Materials and Methods: We established a Hep3B bearing mouse to evaluate the efficacy of the combination treatment of magnolol and RT. Results: Most significantly, tumor volume and tumor weight inhibition was found in the combination group. Tumor immunohistochemistry staining also illustrated the suppression of RT-induced ERK/NF-?B-related proteins expression by magnolol. In addition, intrinsic apoptosis-related proteins, such as caspase-3 and-9, were markedly increased in the combination group. Conclusion: Magnolol may effectively enhance anti-HCC ability of RT by downregulating the expression of ERK/NFB-related proteins and increasing the expression of apoptosis-related proteins.

Original languageEnglish
Pages (from-to)1789-1796
Number of pages8
JournalIn Vivo
Volume34
Issue number4
DOIs
Publication statusPublished - Aug 2020

Keywords

  • Apoptosis
  • Hepatocellular carcinoma
  • Magnolol
  • Radiation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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