The impacts of baseline ventilator parameters on hospital mortality in acute respiratory distress syndrome treated with venovenous extracorporeal membrane oxygenation: A retrospective cohort study

Meng Yu Wu, Yu Sheng Chang, Chung Chi Huang, Tzu I. Wu, Pyng Jing Lin

Research output: Contribution to journalArticle

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Abstract

Background: Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a valuable life support in acute respiratory distress syndrome (ARDS) in adult patients. However, the success of VV-ECMO is known to be influenced by the baseline settings of mechanical ventilation (MV) before its institution. This study was aimed at identifying the baseline ventilator parameters which were independently associated with hospital mortality in non-trauma patients receiving VV-ECMO for severe ARDS. Methods: This retrospective study included 106 non-trauma patients (mean age: 53 years) who received VV-ECMO for ARDS in a single medical center from 2007 to 2016. The indication of VV-ECMO was severe hypoxemia (PaO2/ FiO2 ratio<70 mmHg) under pressure-controlled MV with peak inspiratory pressure (PIP)>35 cmH2O, positive end-expiratory pressure (PEEP)>5 cmH2O, and FiO2>0.8. Important demographic and clinical data before and during VV-ECMO were collected for analysis of hospital mortality. Results: The causes of ARDS were bacterial pneumonia (n=41), viral pneumonia (n=24), aspiration pneumonitis (n=3), and others (n=38). The median duration of MV before ECMO institution was 3 days and the overall hospital mortality was 53% (n=56). The medians of PaO2/ FiO2 ratio, PIP, PEEP, and dynamic pulmonary compliance (PCdyn) at the beginning of MV were 84 mmHg, 32 cmH2O, 10 cmH2O, and 21 mL/cmH2O, respectively. However, before the beginning of VV-ECMO, the medians of PaO2/ FiO2 ratio, PIP, PEEP, and PCdyn became 69 mmHg, 36 cmH2O, 14 cmH2O, and 19 mL/cmH2O, respectively. The escalation of PIP and the declines in PaO2/ FiO2 ratio and PCdyn were significantly correlated with the duration of MV before ECMO institution. Finally, the duration of MV (OR: 1.184, 95% CI: 1.079-1.565, p<0.001) was found to be the only baseline ventilator parameter that independently affected the hospital mortality in these ECMO-treated patients. Conclusion: Since the duration of MV before ECMO institution was strongly correlated to the outcome of adult respiratory ECMO, medical centers are suggested to find a suitable prognosticating tool to determine the starting point of respiratory ECMO among their candidates with different duration of MV. Trial registration: This study reported a health care intervention on human participants and was retrospectively registered. The Chang Gung Medical Foundation Institutional Review Board approved the study (no. 201601483B0 ) on November 23, 2016. All of the data were extracted from December 1, 2016, to January 31, 2017.

Original languageEnglish
Article number181
JournalBMC Pulmonary Medicine
Volume17
Issue number1
DOIs
Publication statusPublished - Dec 8 2017

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Extracorporeal Membrane Oxygenation
Adult Respiratory Distress Syndrome
Mechanical Ventilators
Hospital Mortality
Artificial Respiration
Cohort Studies
Retrospective Studies
Positive-Pressure Respiration
Viral Pneumonia
Lung Compliance
Bacterial Pneumonia
Severe Acute Respiratory Syndrome
Research Ethics Committees
Pneumonia
Demography
Delivery of Health Care

Keywords

  • Adult respiratory distress syndrome
  • Lung recruitment
  • Lung-protective mechanical ventilation
  • Venovenous extracorporeal membrane oxygenation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

The impacts of baseline ventilator parameters on hospital mortality in acute respiratory distress syndrome treated with venovenous extracorporeal membrane oxygenation : A retrospective cohort study. / Wu, Meng Yu; Chang, Yu Sheng; Huang, Chung Chi; Wu, Tzu I.; Lin, Pyng Jing.

In: BMC Pulmonary Medicine, Vol. 17, No. 1, 181, 08.12.2017.

Research output: Contribution to journalArticle

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abstract = "Background: Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a valuable life support in acute respiratory distress syndrome (ARDS) in adult patients. However, the success of VV-ECMO is known to be influenced by the baseline settings of mechanical ventilation (MV) before its institution. This study was aimed at identifying the baseline ventilator parameters which were independently associated with hospital mortality in non-trauma patients receiving VV-ECMO for severe ARDS. Methods: This retrospective study included 106 non-trauma patients (mean age: 53 years) who received VV-ECMO for ARDS in a single medical center from 2007 to 2016. The indication of VV-ECMO was severe hypoxemia (PaO2/ FiO2 ratio<70 mmHg) under pressure-controlled MV with peak inspiratory pressure (PIP)>35 cmH2O, positive end-expiratory pressure (PEEP)>5 cmH2O, and FiO2>0.8. Important demographic and clinical data before and during VV-ECMO were collected for analysis of hospital mortality. Results: The causes of ARDS were bacterial pneumonia (n=41), viral pneumonia (n=24), aspiration pneumonitis (n=3), and others (n=38). The median duration of MV before ECMO institution was 3 days and the overall hospital mortality was 53{\%} (n=56). The medians of PaO2/ FiO2 ratio, PIP, PEEP, and dynamic pulmonary compliance (PCdyn) at the beginning of MV were 84 mmHg, 32 cmH2O, 10 cmH2O, and 21 mL/cmH2O, respectively. However, before the beginning of VV-ECMO, the medians of PaO2/ FiO2 ratio, PIP, PEEP, and PCdyn became 69 mmHg, 36 cmH2O, 14 cmH2O, and 19 mL/cmH2O, respectively. The escalation of PIP and the declines in PaO2/ FiO2 ratio and PCdyn were significantly correlated with the duration of MV before ECMO institution. Finally, the duration of MV (OR: 1.184, 95{\%} CI: 1.079-1.565, p<0.001) was found to be the only baseline ventilator parameter that independently affected the hospital mortality in these ECMO-treated patients. Conclusion: Since the duration of MV before ECMO institution was strongly correlated to the outcome of adult respiratory ECMO, medical centers are suggested to find a suitable prognosticating tool to determine the starting point of respiratory ECMO among their candidates with different duration of MV. Trial registration: This study reported a health care intervention on human participants and was retrospectively registered. The Chang Gung Medical Foundation Institutional Review Board approved the study (no. 201601483B0 ) on November 23, 2016. All of the data were extracted from December 1, 2016, to January 31, 2017.",
keywords = "Adult respiratory distress syndrome, Lung recruitment, Lung-protective mechanical ventilation, Venovenous extracorporeal membrane oxygenation",
author = "Wu, {Meng Yu} and Chang, {Yu Sheng} and Huang, {Chung Chi} and Wu, {Tzu I.} and Lin, {Pyng Jing}",
year = "2017",
month = "12",
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T1 - The impacts of baseline ventilator parameters on hospital mortality in acute respiratory distress syndrome treated with venovenous extracorporeal membrane oxygenation

T2 - A retrospective cohort study

AU - Wu, Meng Yu

AU - Chang, Yu Sheng

AU - Huang, Chung Chi

AU - Wu, Tzu I.

AU - Lin, Pyng Jing

PY - 2017/12/8

Y1 - 2017/12/8

N2 - Background: Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a valuable life support in acute respiratory distress syndrome (ARDS) in adult patients. However, the success of VV-ECMO is known to be influenced by the baseline settings of mechanical ventilation (MV) before its institution. This study was aimed at identifying the baseline ventilator parameters which were independently associated with hospital mortality in non-trauma patients receiving VV-ECMO for severe ARDS. Methods: This retrospective study included 106 non-trauma patients (mean age: 53 years) who received VV-ECMO for ARDS in a single medical center from 2007 to 2016. The indication of VV-ECMO was severe hypoxemia (PaO2/ FiO2 ratio<70 mmHg) under pressure-controlled MV with peak inspiratory pressure (PIP)>35 cmH2O, positive end-expiratory pressure (PEEP)>5 cmH2O, and FiO2>0.8. Important demographic and clinical data before and during VV-ECMO were collected for analysis of hospital mortality. Results: The causes of ARDS were bacterial pneumonia (n=41), viral pneumonia (n=24), aspiration pneumonitis (n=3), and others (n=38). The median duration of MV before ECMO institution was 3 days and the overall hospital mortality was 53% (n=56). The medians of PaO2/ FiO2 ratio, PIP, PEEP, and dynamic pulmonary compliance (PCdyn) at the beginning of MV were 84 mmHg, 32 cmH2O, 10 cmH2O, and 21 mL/cmH2O, respectively. However, before the beginning of VV-ECMO, the medians of PaO2/ FiO2 ratio, PIP, PEEP, and PCdyn became 69 mmHg, 36 cmH2O, 14 cmH2O, and 19 mL/cmH2O, respectively. The escalation of PIP and the declines in PaO2/ FiO2 ratio and PCdyn were significantly correlated with the duration of MV before ECMO institution. Finally, the duration of MV (OR: 1.184, 95% CI: 1.079-1.565, p<0.001) was found to be the only baseline ventilator parameter that independently affected the hospital mortality in these ECMO-treated patients. Conclusion: Since the duration of MV before ECMO institution was strongly correlated to the outcome of adult respiratory ECMO, medical centers are suggested to find a suitable prognosticating tool to determine the starting point of respiratory ECMO among their candidates with different duration of MV. Trial registration: This study reported a health care intervention on human participants and was retrospectively registered. The Chang Gung Medical Foundation Institutional Review Board approved the study (no. 201601483B0 ) on November 23, 2016. All of the data were extracted from December 1, 2016, to January 31, 2017.

AB - Background: Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a valuable life support in acute respiratory distress syndrome (ARDS) in adult patients. However, the success of VV-ECMO is known to be influenced by the baseline settings of mechanical ventilation (MV) before its institution. This study was aimed at identifying the baseline ventilator parameters which were independently associated with hospital mortality in non-trauma patients receiving VV-ECMO for severe ARDS. Methods: This retrospective study included 106 non-trauma patients (mean age: 53 years) who received VV-ECMO for ARDS in a single medical center from 2007 to 2016. The indication of VV-ECMO was severe hypoxemia (PaO2/ FiO2 ratio<70 mmHg) under pressure-controlled MV with peak inspiratory pressure (PIP)>35 cmH2O, positive end-expiratory pressure (PEEP)>5 cmH2O, and FiO2>0.8. Important demographic and clinical data before and during VV-ECMO were collected for analysis of hospital mortality. Results: The causes of ARDS were bacterial pneumonia (n=41), viral pneumonia (n=24), aspiration pneumonitis (n=3), and others (n=38). The median duration of MV before ECMO institution was 3 days and the overall hospital mortality was 53% (n=56). The medians of PaO2/ FiO2 ratio, PIP, PEEP, and dynamic pulmonary compliance (PCdyn) at the beginning of MV were 84 mmHg, 32 cmH2O, 10 cmH2O, and 21 mL/cmH2O, respectively. However, before the beginning of VV-ECMO, the medians of PaO2/ FiO2 ratio, PIP, PEEP, and PCdyn became 69 mmHg, 36 cmH2O, 14 cmH2O, and 19 mL/cmH2O, respectively. The escalation of PIP and the declines in PaO2/ FiO2 ratio and PCdyn were significantly correlated with the duration of MV before ECMO institution. Finally, the duration of MV (OR: 1.184, 95% CI: 1.079-1.565, p<0.001) was found to be the only baseline ventilator parameter that independently affected the hospital mortality in these ECMO-treated patients. Conclusion: Since the duration of MV before ECMO institution was strongly correlated to the outcome of adult respiratory ECMO, medical centers are suggested to find a suitable prognosticating tool to determine the starting point of respiratory ECMO among their candidates with different duration of MV. Trial registration: This study reported a health care intervention on human participants and was retrospectively registered. The Chang Gung Medical Foundation Institutional Review Board approved the study (no. 201601483B0 ) on November 23, 2016. All of the data were extracted from December 1, 2016, to January 31, 2017.

KW - Adult respiratory distress syndrome

KW - Lung recruitment

KW - Lung-protective mechanical ventilation

KW - Venovenous extracorporeal membrane oxygenation

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