The impact of the heptavalent pneumococcal conjugate vaccine on risk factors for streptococcus pneumoniae carriage in children

Yu Chia Hsieh, Cheng Hsun Chiu, Kuang Yi Chang, Yhu Chering Huang, Chih Jung Chen, Chen Yen Kuo, Po Yen Chen, Kao Pin Hwang, Tzou Yien Lin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: The aim of the study was to investigate whether the 7-valent pneumococcal conjugate vaccine (PCV7) alters common risk factors of nasopharyngeal carriage by Streptococcus pneumoniae in children. Methods: From July 2005 through December 2010, we performed a cross-sectional study investigating risk factors associated with pneumococcal carriage in children. Parents of participating children completed questionnaires including whether or not the children received PCV7 vaccination. Results: Among 9705 children, 20.2% of them received at least 1 dose of the PCV7 vaccine. Multivariate logistic regression models identified older age, having 1 sibling in a family, history of acute otitis media and household exposure to smoking as independent risk factors for pneumococcal carriage in the unvaccinated group, but not associated with pneumococcal carriage in the vaccinated group. The number of siblings ≥2 in a family, history of upper respiratory tract infection and child-care attendance were strong factors associated with pneumococcal carriage in children, regardless of vaccination. In vaccinated group, breast-feeding was associated with increased nonvaccine type pneumococcal carriage, mainly in children with upper respiratory tract infection. Conclusions: PCV7 decreased the association between pneumococcal carriage and older age, 1 sibling in a family, history of acute otitis media and household exposure to smoking, but increased the association between pneumococcal carriage and breast-feeding.

Original languageEnglish
JournalPediatric Infectious Disease Journal
Volume31
Issue number9
DOIs
Publication statusPublished - Sep 2012
Externally publishedYes

Fingerprint

Streptococcus pneumoniae
Siblings
Otitis Media
Breast Feeding
Respiratory Tract Infections
Vaccination
Logistic Models
Smoking
Conjugate Vaccines
Pneumococcal Vaccines
Child Care
Heptavalent Pneumococcal Conjugate Vaccine
Cross-Sectional Studies
Parents

Keywords

  • nasopharyngeal carriage
  • pneumococcal conjugate vaccine
  • risk factor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

Cite this

The impact of the heptavalent pneumococcal conjugate vaccine on risk factors for streptococcus pneumoniae carriage in children. / Hsieh, Yu Chia; Chiu, Cheng Hsun; Chang, Kuang Yi; Huang, Yhu Chering; Chen, Chih Jung; Kuo, Chen Yen; Chen, Po Yen; Hwang, Kao Pin; Lin, Tzou Yien.

In: Pediatric Infectious Disease Journal, Vol. 31, No. 9, 09.2012.

Research output: Contribution to journalArticle

Hsieh, Yu Chia ; Chiu, Cheng Hsun ; Chang, Kuang Yi ; Huang, Yhu Chering ; Chen, Chih Jung ; Kuo, Chen Yen ; Chen, Po Yen ; Hwang, Kao Pin ; Lin, Tzou Yien. / The impact of the heptavalent pneumococcal conjugate vaccine on risk factors for streptococcus pneumoniae carriage in children. In: Pediatric Infectious Disease Journal. 2012 ; Vol. 31, No. 9.
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