The Impact of Sequence of Chemotherapy and EGFR-TKI Treatment on Different EGFR Mutation Lung Adenocarcinoma

Fu Tsai Chung, Ming Yun Ho, Yueh Fu Fang, Meng Heng Hshieh, Tsai Yu Wang, Chih Hsi Kuo, Hao Cheng Chen, Chun Hwa Wang, Shu Min Lin, Chih Teng Yu, Horng Chyuan Lin, Han Pin Kuo

Research output: Contribution to journalArticle

Abstract

Objectives. Chemotherapy as first-/second-line treatment in different epidermal growth factor receptor (EGFR) mutation lung adenocarcinoma remains controversial. Methods. Consecutive patients were collected between 2009 and 2012. Patients were divided into two groups (1st-line chemotherapy: n = 56 and 2nd-line chemotherapy: n = 55). Their outcomes profiles were analyzed. Results. The overall survival (OS) of all patients (390 versus 662 days, p < 0.0001), as well as both progression-free survival (PFS, 151 versus 252 days, p = 0.0001) and OS (308 versus 704 days, p = 0.0001) of patients with L858R mutation (n = 63), who received 2nd-line chemotherapy, was significantly poor. By univariate and multivariate analysis, 2nd-line chemotherapy, and L858R mutation were significantly related to poor PFS and OS. Conclusion. In advanced lung adenocarcinoma, L858R mutation and 2nd-line chemotherapy caused a poor outcome. It is a consideration to choice of 1st-line chemotherapy in these subjects. A prospective design is warranted to confirm this finding.

Original languageEnglish
Article number948267
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Fingerprint Dive into the research topics of 'The Impact of Sequence of Chemotherapy and EGFR-TKI Treatment on Different EGFR Mutation Lung Adenocarcinoma'. Together they form a unique fingerprint.

  • Cite this

    Chung, F. T., Ho, M. Y., Fang, Y. F., Hshieh, M. H., Wang, T. Y., Kuo, C. H., Chen, H. C., Wang, C. H., Lin, S. M., Yu, C. T., Lin, H. C., & Kuo, H. P. (2015). The Impact of Sequence of Chemotherapy and EGFR-TKI Treatment on Different EGFR Mutation Lung Adenocarcinoma. BioMed Research International, 2015, [948267]. https://doi.org/10.1155/2015/948267