The impact of organized mammography service screening on breast carcinoma mortality in seven Swedish Counties: A collaborative evaluation

Stephen W. Duffy, Laszlo Tabár, Hsiu Hsi Chen, Marit Holmqvist, Ming Fang Yen, Shahim Abdsalah, Birgitta Epstein, Ewa Frodis, Eva Ljungberg, Christina Hedborg-Melander, Ann Sundbom, Maria Tholin, Mika Wiege, Anders Åkerlund, Hui Min Wu, Tao Shin Tung, Yueh Hsia Chiu, Chen Pu Chiu, Chih Chung Huang, Robert A. SmithMåns Rosén, Magnus Stenbeck, Lars Holmberg

Research output: Contribution to journalArticle

320 Citations (Scopus)

Abstract

BACKGROUND. The evaluation of organized mammographic service screening programs is a major challenge in public health. In particular, there is a need to evaluate the effect of the screening program on the mortality of breast carcinoma, uncontaminated in the screening epoch by mortality from 1) cases diagnosed in the prescreening period and 2) cases diagnosed among unscreened women (i.e., nonattenders) after the initiation of organized screening. METHODS. In the current study, the authors ascertained breast carcinoma deaths in the prescreening and screening epochs in 7 Swedish counties from tumors diagnosed in these epochs and in the age group 40-69 years in 6 counties and 50-69 years in 1 county. Data regarding deaths were obtained from the Uppsala Regional Oncologic Center in conjunction with the National Cause of Death Register. The total number of women in the eligible age range living in each county was obtained from the annual population data of Statistics Sweden. Detailed screening data were provided by the screening centers in the seven counties, including the number of invited, the number attended, and whether each individual breast carcinoma case was exposed (screen-detected and interval cases combined) or unexposed (not-invited or nonattenders) to mammographic screening. There were 2044 breast carcinoma deaths from 14,092 incident tumors diagnosed in the prescreening and screening epochs, and the total number of person-years was 7.5 million. Data were analyzed using Poisson regression with corrections for self-selection bias and lead-time bias when appropriate. RESULTS. The mortality reduction for breast carcinoma in all 7 counties combined for women actually exposed to screening compared with the prescreening period was 44% (relative risk [RR] = 0.56; 95% confidence interval [95% CI], 0.50-0.62). When all incident tumors were considered, both those exposed and those unexposed to screening combined, counties with > 10 years of screening were found to demonstrate a significant 32% mortality reduction (RR = 0.68; 95% CI, 0.60-0.77) and counties with ≤ 10 years of screening showed a significant 18% reduction in breast carcinoma mortality (RR = 0.82; 95% CI, 0.72-0.94) for the screening epoch compared with the prescreening epoch. Within the screening epoch, after adjustment for self-selection bias, a 39% mortality reduction (RR = 0.61; 95%CI, 0.55-0.68) was observed in association with invitation to screening. CONCLUSIONS. Organized service screening in 7 Swedish counties, covering approximately 33% of the population of Sweden, resulted in a 40-45% reduction in breast carcinoma mortality among women actually screened. The policy of offering screening is associated with a mortality reduction in breast carcinoma of 30% in the invited population, exposed and unexposed combined. The results of the current study indicate that the majority of the breast carcinoma mortality reduction is indeed due to the screening.

Original languageEnglish
Pages (from-to)458-469
Number of pages12
JournalCancer
Volume95
Issue number3
DOIs
Publication statusPublished - Aug 1 2002
Externally publishedYes

Fingerprint

Mammography
Breast Neoplasms
Mortality
Selection Bias
Confidence Intervals
Sweden
Neoplasms
Population Characteristics
Population
Cause of Death
Public Health
Age Groups

Keywords

  • Breast carcinoma
  • Mammography
  • Mortality reduction
  • Screening
  • Sweden

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The impact of organized mammography service screening on breast carcinoma mortality in seven Swedish Counties : A collaborative evaluation. / Duffy, Stephen W.; Tabár, Laszlo; Chen, Hsiu Hsi; Holmqvist, Marit; Yen, Ming Fang; Abdsalah, Shahim; Epstein, Birgitta; Frodis, Ewa; Ljungberg, Eva; Hedborg-Melander, Christina; Sundbom, Ann; Tholin, Maria; Wiege, Mika; Åkerlund, Anders; Wu, Hui Min; Tung, Tao Shin; Chiu, Yueh Hsia; Chiu, Chen Pu; Huang, Chih Chung; Smith, Robert A.; Rosén, Måns; Stenbeck, Magnus; Holmberg, Lars.

In: Cancer, Vol. 95, No. 3, 01.08.2002, p. 458-469.

Research output: Contribution to journalArticle

Duffy, SW, Tabár, L, Chen, HH, Holmqvist, M, Yen, MF, Abdsalah, S, Epstein, B, Frodis, E, Ljungberg, E, Hedborg-Melander, C, Sundbom, A, Tholin, M, Wiege, M, Åkerlund, A, Wu, HM, Tung, TS, Chiu, YH, Chiu, CP, Huang, CC, Smith, RA, Rosén, M, Stenbeck, M & Holmberg, L 2002, 'The impact of organized mammography service screening on breast carcinoma mortality in seven Swedish Counties: A collaborative evaluation', Cancer, vol. 95, no. 3, pp. 458-469. https://doi.org/10.1002/cncr.10765
Duffy, Stephen W. ; Tabár, Laszlo ; Chen, Hsiu Hsi ; Holmqvist, Marit ; Yen, Ming Fang ; Abdsalah, Shahim ; Epstein, Birgitta ; Frodis, Ewa ; Ljungberg, Eva ; Hedborg-Melander, Christina ; Sundbom, Ann ; Tholin, Maria ; Wiege, Mika ; Åkerlund, Anders ; Wu, Hui Min ; Tung, Tao Shin ; Chiu, Yueh Hsia ; Chiu, Chen Pu ; Huang, Chih Chung ; Smith, Robert A. ; Rosén, Måns ; Stenbeck, Magnus ; Holmberg, Lars. / The impact of organized mammography service screening on breast carcinoma mortality in seven Swedish Counties : A collaborative evaluation. In: Cancer. 2002 ; Vol. 95, No. 3. pp. 458-469.
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abstract = "BACKGROUND. The evaluation of organized mammographic service screening programs is a major challenge in public health. In particular, there is a need to evaluate the effect of the screening program on the mortality of breast carcinoma, uncontaminated in the screening epoch by mortality from 1) cases diagnosed in the prescreening period and 2) cases diagnosed among unscreened women (i.e., nonattenders) after the initiation of organized screening. METHODS. In the current study, the authors ascertained breast carcinoma deaths in the prescreening and screening epochs in 7 Swedish counties from tumors diagnosed in these epochs and in the age group 40-69 years in 6 counties and 50-69 years in 1 county. Data regarding deaths were obtained from the Uppsala Regional Oncologic Center in conjunction with the National Cause of Death Register. The total number of women in the eligible age range living in each county was obtained from the annual population data of Statistics Sweden. Detailed screening data were provided by the screening centers in the seven counties, including the number of invited, the number attended, and whether each individual breast carcinoma case was exposed (screen-detected and interval cases combined) or unexposed (not-invited or nonattenders) to mammographic screening. There were 2044 breast carcinoma deaths from 14,092 incident tumors diagnosed in the prescreening and screening epochs, and the total number of person-years was 7.5 million. Data were analyzed using Poisson regression with corrections for self-selection bias and lead-time bias when appropriate. RESULTS. The mortality reduction for breast carcinoma in all 7 counties combined for women actually exposed to screening compared with the prescreening period was 44{\%} (relative risk [RR] = 0.56; 95{\%} confidence interval [95{\%} CI], 0.50-0.62). When all incident tumors were considered, both those exposed and those unexposed to screening combined, counties with > 10 years of screening were found to demonstrate a significant 32{\%} mortality reduction (RR = 0.68; 95{\%} CI, 0.60-0.77) and counties with ≤ 10 years of screening showed a significant 18{\%} reduction in breast carcinoma mortality (RR = 0.82; 95{\%} CI, 0.72-0.94) for the screening epoch compared with the prescreening epoch. Within the screening epoch, after adjustment for self-selection bias, a 39{\%} mortality reduction (RR = 0.61; 95{\%}CI, 0.55-0.68) was observed in association with invitation to screening. CONCLUSIONS. Organized service screening in 7 Swedish counties, covering approximately 33{\%} of the population of Sweden, resulted in a 40-45{\%} reduction in breast carcinoma mortality among women actually screened. The policy of offering screening is associated with a mortality reduction in breast carcinoma of 30{\%} in the invited population, exposed and unexposed combined. The results of the current study indicate that the majority of the breast carcinoma mortality reduction is indeed due to the screening.",
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TY - JOUR

T1 - The impact of organized mammography service screening on breast carcinoma mortality in seven Swedish Counties

T2 - A collaborative evaluation

AU - Duffy, Stephen W.

AU - Tabár, Laszlo

AU - Chen, Hsiu Hsi

AU - Holmqvist, Marit

AU - Yen, Ming Fang

AU - Abdsalah, Shahim

AU - Epstein, Birgitta

AU - Frodis, Ewa

AU - Ljungberg, Eva

AU - Hedborg-Melander, Christina

AU - Sundbom, Ann

AU - Tholin, Maria

AU - Wiege, Mika

AU - Åkerlund, Anders

AU - Wu, Hui Min

AU - Tung, Tao Shin

AU - Chiu, Yueh Hsia

AU - Chiu, Chen Pu

AU - Huang, Chih Chung

AU - Smith, Robert A.

AU - Rosén, Måns

AU - Stenbeck, Magnus

AU - Holmberg, Lars

PY - 2002/8/1

Y1 - 2002/8/1

N2 - BACKGROUND. The evaluation of organized mammographic service screening programs is a major challenge in public health. In particular, there is a need to evaluate the effect of the screening program on the mortality of breast carcinoma, uncontaminated in the screening epoch by mortality from 1) cases diagnosed in the prescreening period and 2) cases diagnosed among unscreened women (i.e., nonattenders) after the initiation of organized screening. METHODS. In the current study, the authors ascertained breast carcinoma deaths in the prescreening and screening epochs in 7 Swedish counties from tumors diagnosed in these epochs and in the age group 40-69 years in 6 counties and 50-69 years in 1 county. Data regarding deaths were obtained from the Uppsala Regional Oncologic Center in conjunction with the National Cause of Death Register. The total number of women in the eligible age range living in each county was obtained from the annual population data of Statistics Sweden. Detailed screening data were provided by the screening centers in the seven counties, including the number of invited, the number attended, and whether each individual breast carcinoma case was exposed (screen-detected and interval cases combined) or unexposed (not-invited or nonattenders) to mammographic screening. There were 2044 breast carcinoma deaths from 14,092 incident tumors diagnosed in the prescreening and screening epochs, and the total number of person-years was 7.5 million. Data were analyzed using Poisson regression with corrections for self-selection bias and lead-time bias when appropriate. RESULTS. The mortality reduction for breast carcinoma in all 7 counties combined for women actually exposed to screening compared with the prescreening period was 44% (relative risk [RR] = 0.56; 95% confidence interval [95% CI], 0.50-0.62). When all incident tumors were considered, both those exposed and those unexposed to screening combined, counties with > 10 years of screening were found to demonstrate a significant 32% mortality reduction (RR = 0.68; 95% CI, 0.60-0.77) and counties with ≤ 10 years of screening showed a significant 18% reduction in breast carcinoma mortality (RR = 0.82; 95% CI, 0.72-0.94) for the screening epoch compared with the prescreening epoch. Within the screening epoch, after adjustment for self-selection bias, a 39% mortality reduction (RR = 0.61; 95%CI, 0.55-0.68) was observed in association with invitation to screening. CONCLUSIONS. Organized service screening in 7 Swedish counties, covering approximately 33% of the population of Sweden, resulted in a 40-45% reduction in breast carcinoma mortality among women actually screened. The policy of offering screening is associated with a mortality reduction in breast carcinoma of 30% in the invited population, exposed and unexposed combined. The results of the current study indicate that the majority of the breast carcinoma mortality reduction is indeed due to the screening.

AB - BACKGROUND. The evaluation of organized mammographic service screening programs is a major challenge in public health. In particular, there is a need to evaluate the effect of the screening program on the mortality of breast carcinoma, uncontaminated in the screening epoch by mortality from 1) cases diagnosed in the prescreening period and 2) cases diagnosed among unscreened women (i.e., nonattenders) after the initiation of organized screening. METHODS. In the current study, the authors ascertained breast carcinoma deaths in the prescreening and screening epochs in 7 Swedish counties from tumors diagnosed in these epochs and in the age group 40-69 years in 6 counties and 50-69 years in 1 county. Data regarding deaths were obtained from the Uppsala Regional Oncologic Center in conjunction with the National Cause of Death Register. The total number of women in the eligible age range living in each county was obtained from the annual population data of Statistics Sweden. Detailed screening data were provided by the screening centers in the seven counties, including the number of invited, the number attended, and whether each individual breast carcinoma case was exposed (screen-detected and interval cases combined) or unexposed (not-invited or nonattenders) to mammographic screening. There were 2044 breast carcinoma deaths from 14,092 incident tumors diagnosed in the prescreening and screening epochs, and the total number of person-years was 7.5 million. Data were analyzed using Poisson regression with corrections for self-selection bias and lead-time bias when appropriate. RESULTS. The mortality reduction for breast carcinoma in all 7 counties combined for women actually exposed to screening compared with the prescreening period was 44% (relative risk [RR] = 0.56; 95% confidence interval [95% CI], 0.50-0.62). When all incident tumors were considered, both those exposed and those unexposed to screening combined, counties with > 10 years of screening were found to demonstrate a significant 32% mortality reduction (RR = 0.68; 95% CI, 0.60-0.77) and counties with ≤ 10 years of screening showed a significant 18% reduction in breast carcinoma mortality (RR = 0.82; 95% CI, 0.72-0.94) for the screening epoch compared with the prescreening epoch. Within the screening epoch, after adjustment for self-selection bias, a 39% mortality reduction (RR = 0.61; 95%CI, 0.55-0.68) was observed in association with invitation to screening. CONCLUSIONS. Organized service screening in 7 Swedish counties, covering approximately 33% of the population of Sweden, resulted in a 40-45% reduction in breast carcinoma mortality among women actually screened. The policy of offering screening is associated with a mortality reduction in breast carcinoma of 30% in the invited population, exposed and unexposed combined. The results of the current study indicate that the majority of the breast carcinoma mortality reduction is indeed due to the screening.

KW - Breast carcinoma

KW - Mammography

KW - Mortality reduction

KW - Screening

KW - Sweden

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