The impact of oral herpes simplex virus infection and candidiasis on chemotherapy-induced oral mucositis among patients with hematological malignancies

Y. K. Chen, H. A. Hou, Jyh-Ming Chow, Y. C. Chen, Po Ren Hsueh, Hwei Fang Tien

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The aim of this study was to evaluate the influences of oral candidiasis and herpes simplex virus 1 (HSV-1) infections in chemotherapy-induced oral mucositis (OM). The medical records of 424 consecutive patients with hematological malignancies who had received chemotherapy at a medical center in Taiwan from January 2006 to November 2007 were retrospectively reviewed. The results of swab cultures of fungus and HSV-1 for OM were correlated with associated clinical features. Younger age, myeloid malignancies, and disease status other than complete remission before chemotherapy were significantly correlated with the development of OM. Risks of fever (p

Original languageEnglish
Pages (from-to)753-759
Number of pages7
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Issue number6
Publication statusPublished - Jun 2011


ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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