The impact of chronic carrier of hepatitis B virus on liver function in a 7-day ultramarathon race

Shang Lin Chou, Ming Yueh Chou, Yu Hsuan Wang, Fon Chu Kuo, Wei-Fong Kao

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Several changes in physiological characteristics occur during long-distance and 24-hour ultramarathons, including hyponatremia, skeletal muscle breakdown, plasma volume changes, iron depletion, anemia, and possible hepatic damage. The purpose of this study was to investigate the impact of hepatitis B virus (HBV) carrier status on liver function during multi-day races. Methods: This prospective study recruited 10 Taiwanese runners who were scheduled to participate in the 7-day 2008 Athens Ultramarathon Festival Race, and three of them were chronic carriers of HBV. Blood samples were collected before, during, and 3 days after the race, including alkaline phosphatase (ALP), albumin (ALB), total protein (TP) levels, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (T-BIL). Results: Ten Taiwanese runners (40% female; average age 52.3 ± 7.9 years) who all planned to run in the race were recruited. Three runners were chronic carriers of HBV (HBV carrier), and all participants were anti-HCV antibody-negative and anti-hepatitis A virus (HAV) IgG-positive. There were no significant time-by-group effects on ALP, ALB, and TP levels, but the change over time effects were significant (p <0.001, p = 0.001 and p = 0.010, respectively). ALT, AST, and T-BIL increased significantly to markedly higher levels in the HBV carrier group compared to the non-carrier group (group effect p = 0.009, p = 0.004, and p = 0.05, respectively), and the time-by-group interaction was also significant for these liver function markers (p <0.001, p <0.001, and p = 0.001, respectively). Conclusion: Compared to their counterparts, runners who are HBV carriers had significantly greater increases in levels of ALT, AST, and T-BIL during a 7-day ultramarathon, indicating that the liver function of carriers is more highly impacted in these races.

Original languageEnglish
Pages (from-to)179-184
JournalJournal of the Chinese Medical Association
Volume79
Issue number4
DOIs
Publication statusPublished - Apr 1 2016

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Chronic Hepatitis B
Hepatitis B virus
Liver
Aspartate Aminotransferases
Alanine Transaminase
Bilirubin
Alkaline Phosphatase
Albumins
Hepatitis A virus
Holidays
Hepatitis C Antibodies
Hyponatremia
Plasma Volume
Anemia
Skeletal Muscle
Proteins
Iron
Immunoglobulin G
Prospective Studies

Keywords

  • 7-day races
  • Hepatitis B virus (HBV)
  • Liver function
  • Ultramarathon

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The impact of chronic carrier of hepatitis B virus on liver function in a 7-day ultramarathon race. / Chou, Shang Lin; Chou, Ming Yueh; Wang, Yu Hsuan; Kuo, Fon Chu; Kao, Wei-Fong.

In: Journal of the Chinese Medical Association, Vol. 79, No. 4, 01.04.2016, p. 179-184.

Research output: Contribution to journalArticle

Chou, Shang Lin ; Chou, Ming Yueh ; Wang, Yu Hsuan ; Kuo, Fon Chu ; Kao, Wei-Fong. / The impact of chronic carrier of hepatitis B virus on liver function in a 7-day ultramarathon race. In: Journal of the Chinese Medical Association. 2016 ; Vol. 79, No. 4. pp. 179-184.
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AU - Kuo, Fon Chu

AU - Kao, Wei-Fong

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KW - 7-day races

KW - Hepatitis B virus (HBV)

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KW - Ultramarathon

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