The immunomodulatory effects of lactic acid bacteria for improving immune functions and benefits

Yueh Ting Tsai, Po Ching Cheng, Tzu Ming Pan

Research output: Contribution to journalArticlepeer-review

156 Citations (Scopus)


Probiotics have a number of beneficial health effects in humans and animals, such as reducing lactose intolerance symptoms and enhancing the bioavailability of nutrients. Probiotics help regulate intestinal microflora and immunomodulatory properties. Probiotics also decrease the prevalence of allergies in susceptible individuals, inhibit the inflammatory responses in the gut, and have antagonistic effects against intestinal and food-borne pathogens. Bacteria typically colonize the intestinal tract first and then reinforce the host defense systems by inducing generalized mucosal immune responses, including modulation of DC/NK interaction, a balanced T-helper cell response, self-limited inflammatory response, and the secretion of polymeric IgA. A lot of reports showed that lactic acid bacteria (LAB) as Lactobacillus and Bifidobacterium and their fermented products are effective at enhancing innate and adaptive immunity, prevent gastric mucosal lesion development, alleviate allergies, and put up defense against intestinal pathogen infection. In this review paper, we compared the influence of immunomodulatory effects on the function and efficacy of lactobacillus products with different strains. We also discuss the beneficial effects of several LAB strain and its derivative products for human immunity and related diseases.

Original languageEnglish
Pages (from-to)853-862
Number of pages10
JournalApplied Microbiology and Biotechnology
Issue number4
Publication statusPublished - Nov 2012


  • Allergy
  • Escherichia coli O157:H7
  • Innateimmuneresponse .Mucosalimmunity
  • Lactobacillus paracasei subsp. paracasei NTU 101

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology


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