The identification of monoclonality in human aberrant crypt foci

I. Mei Siu, Dan R. Robinson, Stuart Schwartz, Hsing Jien Kung, Thomas G. Pretlow, Robert B. Petersen, Theresa P. Pretlow

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Malignant neoplasms, including colon cancers, are thought to arise from a single initiated progenitor cell. Aberrant crypt foci (ACF) are putative precursors of at least some colon cancers. The pattern of X chromosomal inactivation, which is identified by the differential methylation of a site near a polymorphic CAG repeat in the androgen receptor gene, was used to determine the clonality status of 11 ACF from eight female patients. Ten of 11 ACF were found to be monoclonal aberrations. The eleventh ACF appeared monoclonal, but nonrandom inactivation of the X chromosome was also seen in normal crypts from this patient. These results clearly demonstrate that: (a) a high percentage of ACF lesions are neoplastic rather than hyperplastic; and (b) ACF are the earliest identified neoplastic lesions in the colon.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalCancer Research
Volume59
Issue number1
Publication statusPublished - Jan 1 1999
Externally publishedYes

Fingerprint

Aberrant Crypt Foci
X Chromosome Inactivation
Colonic Neoplasms
Androgen Receptors
Methylation
Colon
Stem Cells
Genes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Siu, I. M., Robinson, D. R., Schwartz, S., Kung, H. J., Pretlow, T. G., Petersen, R. B., & Pretlow, T. P. (1999). The identification of monoclonality in human aberrant crypt foci. Cancer Research, 59(1), 63-66.

The identification of monoclonality in human aberrant crypt foci. / Siu, I. Mei; Robinson, Dan R.; Schwartz, Stuart; Kung, Hsing Jien; Pretlow, Thomas G.; Petersen, Robert B.; Pretlow, Theresa P.

In: Cancer Research, Vol. 59, No. 1, 01.01.1999, p. 63-66.

Research output: Contribution to journalArticle

Siu, IM, Robinson, DR, Schwartz, S, Kung, HJ, Pretlow, TG, Petersen, RB & Pretlow, TP 1999, 'The identification of monoclonality in human aberrant crypt foci', Cancer Research, vol. 59, no. 1, pp. 63-66.
Siu IM, Robinson DR, Schwartz S, Kung HJ, Pretlow TG, Petersen RB et al. The identification of monoclonality in human aberrant crypt foci. Cancer Research. 1999 Jan 1;59(1):63-66.
Siu, I. Mei ; Robinson, Dan R. ; Schwartz, Stuart ; Kung, Hsing Jien ; Pretlow, Thomas G. ; Petersen, Robert B. ; Pretlow, Theresa P. / The identification of monoclonality in human aberrant crypt foci. In: Cancer Research. 1999 ; Vol. 59, No. 1. pp. 63-66.
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