The human mast cell: functions in physiology and disease.

G. Krishnaswamy, J. Kelley, D. Johnson, G. Youngberg, W. Stone, S. K. Huang, J. Bieber, D. S. Chi

Research output: Contribution to journalReview article

173 Citations (Scopus)

Abstract

Mast cells are multifunctional, tissue-dwelling cells capable of secreting a wide variety of mediators. They develop from bone marrow-derived progenitor cells, primed with stem cell factor (SCF), which mediates its actions by interacting with the SCF receptor or c-kit on the cell surface. Mast cells continue their maturation and differentiation in peripheral tissue, developing into two well described subsets of cells, MCT and MCTC cells, varying in content of tryptase and chymase as well as in immunobiology. Mast cells are activated by numerous stimuli, including antigen (acting via the high affinity IgE receptor, Fc?RI), superoxides, complement proteins, neuropeptides and lipoproteins resulting in activation and degranulation. Following activation, these cells express mediators such as histamine, leukotrienes and prostanoids, as well as proteases, and many cytokines and chemokines, pivotal to the genesis of an inflammatory response. Recent data suggests that mast cells may play an active role in such diverse diseases as atherosclerosis, malignancy, asthma, pulmonary fibrosis and arthritis. Mast cells directly interact with bacteria and appear to play a vital role in host defense against pathogens. Drugs, such as glucocorticoids, cyclosporine and cromolyn have been demonstrated to have inhibitory effects on mast cell degranulation or mediator release.

Original languageEnglish
JournalFrontiers in bioscience : a journal and virtual library
Volume6
Publication statusPublished - Jan 1 2001
Externally publishedYes

Fingerprint

Physiology
Mast Cells
Chemical activation
Proto-Oncogene Proteins c-kit
Tissue
Chymases
IgE Receptors
Tryptases
Cromolyn Sodium
Stem Cell Factor
Leukotrienes
Pathogens
Neuropeptides
Chemokines
Superoxides
Histamine
Cyclosporine
Glucocorticoids
Lipoproteins
Prostaglandins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Krishnaswamy, G., Kelley, J., Johnson, D., Youngberg, G., Stone, W., Huang, S. K., ... Chi, D. S. (2001). The human mast cell: functions in physiology and disease. Frontiers in bioscience : a journal and virtual library, 6.

The human mast cell : functions in physiology and disease. / Krishnaswamy, G.; Kelley, J.; Johnson, D.; Youngberg, G.; Stone, W.; Huang, S. K.; Bieber, J.; Chi, D. S.

In: Frontiers in bioscience : a journal and virtual library, Vol. 6, 01.01.2001.

Research output: Contribution to journalReview article

Krishnaswamy, G, Kelley, J, Johnson, D, Youngberg, G, Stone, W, Huang, SK, Bieber, J & Chi, DS 2001, 'The human mast cell: functions in physiology and disease.', Frontiers in bioscience : a journal and virtual library, vol. 6.
Krishnaswamy, G. ; Kelley, J. ; Johnson, D. ; Youngberg, G. ; Stone, W. ; Huang, S. K. ; Bieber, J. ; Chi, D. S. / The human mast cell : functions in physiology and disease. In: Frontiers in bioscience : a journal and virtual library. 2001 ; Vol. 6.
@article{40b31f33c43643198453f03a1babff82,
title = "The human mast cell: functions in physiology and disease.",
abstract = "Mast cells are multifunctional, tissue-dwelling cells capable of secreting a wide variety of mediators. They develop from bone marrow-derived progenitor cells, primed with stem cell factor (SCF), which mediates its actions by interacting with the SCF receptor or c-kit on the cell surface. Mast cells continue their maturation and differentiation in peripheral tissue, developing into two well described subsets of cells, MCT and MCTC cells, varying in content of tryptase and chymase as well as in immunobiology. Mast cells are activated by numerous stimuli, including antigen (acting via the high affinity IgE receptor, Fc?RI), superoxides, complement proteins, neuropeptides and lipoproteins resulting in activation and degranulation. Following activation, these cells express mediators such as histamine, leukotrienes and prostanoids, as well as proteases, and many cytokines and chemokines, pivotal to the genesis of an inflammatory response. Recent data suggests that mast cells may play an active role in such diverse diseases as atherosclerosis, malignancy, asthma, pulmonary fibrosis and arthritis. Mast cells directly interact with bacteria and appear to play a vital role in host defense against pathogens. Drugs, such as glucocorticoids, cyclosporine and cromolyn have been demonstrated to have inhibitory effects on mast cell degranulation or mediator release.",
author = "G. Krishnaswamy and J. Kelley and D. Johnson and G. Youngberg and W. Stone and Huang, {S. K.} and J. Bieber and Chi, {D. S.}",
year = "2001",
month = "1",
day = "1",
language = "English",
volume = "6",
journal = "Frontiers in Bioscience - Landmark",
issn = "1093-9946",
publisher = "Frontiers in Bioscience",

}

TY - JOUR

T1 - The human mast cell

T2 - functions in physiology and disease.

AU - Krishnaswamy, G.

AU - Kelley, J.

AU - Johnson, D.

AU - Youngberg, G.

AU - Stone, W.

AU - Huang, S. K.

AU - Bieber, J.

AU - Chi, D. S.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Mast cells are multifunctional, tissue-dwelling cells capable of secreting a wide variety of mediators. They develop from bone marrow-derived progenitor cells, primed with stem cell factor (SCF), which mediates its actions by interacting with the SCF receptor or c-kit on the cell surface. Mast cells continue their maturation and differentiation in peripheral tissue, developing into two well described subsets of cells, MCT and MCTC cells, varying in content of tryptase and chymase as well as in immunobiology. Mast cells are activated by numerous stimuli, including antigen (acting via the high affinity IgE receptor, Fc?RI), superoxides, complement proteins, neuropeptides and lipoproteins resulting in activation and degranulation. Following activation, these cells express mediators such as histamine, leukotrienes and prostanoids, as well as proteases, and many cytokines and chemokines, pivotal to the genesis of an inflammatory response. Recent data suggests that mast cells may play an active role in such diverse diseases as atherosclerosis, malignancy, asthma, pulmonary fibrosis and arthritis. Mast cells directly interact with bacteria and appear to play a vital role in host defense against pathogens. Drugs, such as glucocorticoids, cyclosporine and cromolyn have been demonstrated to have inhibitory effects on mast cell degranulation or mediator release.

AB - Mast cells are multifunctional, tissue-dwelling cells capable of secreting a wide variety of mediators. They develop from bone marrow-derived progenitor cells, primed with stem cell factor (SCF), which mediates its actions by interacting with the SCF receptor or c-kit on the cell surface. Mast cells continue their maturation and differentiation in peripheral tissue, developing into two well described subsets of cells, MCT and MCTC cells, varying in content of tryptase and chymase as well as in immunobiology. Mast cells are activated by numerous stimuli, including antigen (acting via the high affinity IgE receptor, Fc?RI), superoxides, complement proteins, neuropeptides and lipoproteins resulting in activation and degranulation. Following activation, these cells express mediators such as histamine, leukotrienes and prostanoids, as well as proteases, and many cytokines and chemokines, pivotal to the genesis of an inflammatory response. Recent data suggests that mast cells may play an active role in such diverse diseases as atherosclerosis, malignancy, asthma, pulmonary fibrosis and arthritis. Mast cells directly interact with bacteria and appear to play a vital role in host defense against pathogens. Drugs, such as glucocorticoids, cyclosporine and cromolyn have been demonstrated to have inhibitory effects on mast cell degranulation or mediator release.

UR - http://www.scopus.com/inward/record.url?scp=0035458839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035458839&partnerID=8YFLogxK

M3 - Review article

C2 - 11532608

AN - SCOPUS:0035458839

VL - 6

JO - Frontiers in Bioscience - Landmark

JF - Frontiers in Bioscience - Landmark

SN - 1093-9946

ER -