The high resolution computed tomography in assessment of patients with emphysema following smoking cessation

Tin Myo Hlaing, Yu Sophie Wang, Shih Min Chen, Jeng Shing Wang

Research output: Contribution to journalArticle

Abstract

The purpose of our study was to evaluate the short-term effect of changes in smoking cessation on subjects with chest high resolution computed tomography (HRCT)-diagnosed emphysema, both cross-sectionally and longitudinally. All patients participated in 3 months smoking cessation program.A detailed clinical history was taken and physical examination performed. We performed serum study, lung function testing and HRCT scanning to assess emphysema. After participation in the program, there was a significant increment in body mass index (0.88 kg/m2, p <0.001). There was a significant decline in forced expiratory volume in one second (3.0 % (33 ml), p <0.001), but smaller than decline in smokers. There was also a significant decline in C-reactive protein (0.40 mg/L, p <0.001) & St. George's Respiratory Questionnaire (21, p <0.001). In CT image, there were significant decreases in mean lung density and the attenuation value separating the least 15% pixels (7.7 HU, p <0.001), but a significant increase in the percentage of the relative area of the lungs with attenuation values <-950 Hounsfield unit (1.9%, p <0.001). There were significant declines in smoking, modified Medical Research Council scale, Age-Dyspnea-Obstruction (ADO) index, Dyspnea-Obstruction-Smoking-Exacerbation (DOSE) index (all p <0.001), and exacerbation (p <0.01), but a significant increase in emphysema severity (p <0.05). This study shows the possible important change of HRCT in patients with emphysema following smoking cessation.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalJournal of Internal Medicine of Taiwan
Volume26
Issue number2
Publication statusPublished - Apr 1 2015

Fingerprint

Emphysema
Smoking Cessation
Tomography
Dyspnea
Lung
Smoking
Forced Expiratory Volume
C-Reactive Protein
Physical Examination
Biomedical Research
Body Mass Index
Thorax
Serum

Keywords

  • Emphysema
  • High resolution computed tomography
  • Mean lung density
  • Percentile
  • Relative area
  • Smoking cessation

ASJC Scopus subject areas

  • Internal Medicine

Cite this

The high resolution computed tomography in assessment of patients with emphysema following smoking cessation. / Hlaing, Tin Myo; Wang, Yu Sophie; Chen, Shih Min; Wang, Jeng Shing.

In: Journal of Internal Medicine of Taiwan, Vol. 26, No. 2, 01.04.2015, p. 107-114.

Research output: Contribution to journalArticle

Hlaing, Tin Myo ; Wang, Yu Sophie ; Chen, Shih Min ; Wang, Jeng Shing. / The high resolution computed tomography in assessment of patients with emphysema following smoking cessation. In: Journal of Internal Medicine of Taiwan. 2015 ; Vol. 26, No. 2. pp. 107-114.
@article{7785238a44aa4695a849cb5440444d55,
title = "The high resolution computed tomography in assessment of patients with emphysema following smoking cessation",
abstract = "The purpose of our study was to evaluate the short-term effect of changes in smoking cessation on subjects with chest high resolution computed tomography (HRCT)-diagnosed emphysema, both cross-sectionally and longitudinally. All patients participated in 3 months smoking cessation program.A detailed clinical history was taken and physical examination performed. We performed serum study, lung function testing and HRCT scanning to assess emphysema. After participation in the program, there was a significant increment in body mass index (0.88 kg/m2, p <0.001). There was a significant decline in forced expiratory volume in one second (3.0 {\%} (33 ml), p <0.001), but smaller than decline in smokers. There was also a significant decline in C-reactive protein (0.40 mg/L, p <0.001) & St. George's Respiratory Questionnaire (21, p <0.001). In CT image, there were significant decreases in mean lung density and the attenuation value separating the least 15{\%} pixels (7.7 HU, p <0.001), but a significant increase in the percentage of the relative area of the lungs with attenuation values <-950 Hounsfield unit (1.9{\%}, p <0.001). There were significant declines in smoking, modified Medical Research Council scale, Age-Dyspnea-Obstruction (ADO) index, Dyspnea-Obstruction-Smoking-Exacerbation (DOSE) index (all p <0.001), and exacerbation (p <0.01), but a significant increase in emphysema severity (p <0.05). This study shows the possible important change of HRCT in patients with emphysema following smoking cessation.",
keywords = "Emphysema, High resolution computed tomography, Mean lung density, Percentile, Relative area, Smoking cessation",
author = "Hlaing, {Tin Myo} and Wang, {Yu Sophie} and Chen, {Shih Min} and Wang, {Jeng Shing}",
year = "2015",
month = "4",
day = "1",
language = "English",
volume = "26",
pages = "107--114",
journal = "Journal of Internal Medicine of Taiwan",
issn = "1016-7390",
publisher = "臺灣內科醫學會",
number = "2",

}

TY - JOUR

T1 - The high resolution computed tomography in assessment of patients with emphysema following smoking cessation

AU - Hlaing, Tin Myo

AU - Wang, Yu Sophie

AU - Chen, Shih Min

AU - Wang, Jeng Shing

PY - 2015/4/1

Y1 - 2015/4/1

N2 - The purpose of our study was to evaluate the short-term effect of changes in smoking cessation on subjects with chest high resolution computed tomography (HRCT)-diagnosed emphysema, both cross-sectionally and longitudinally. All patients participated in 3 months smoking cessation program.A detailed clinical history was taken and physical examination performed. We performed serum study, lung function testing and HRCT scanning to assess emphysema. After participation in the program, there was a significant increment in body mass index (0.88 kg/m2, p <0.001). There was a significant decline in forced expiratory volume in one second (3.0 % (33 ml), p <0.001), but smaller than decline in smokers. There was also a significant decline in C-reactive protein (0.40 mg/L, p <0.001) & St. George's Respiratory Questionnaire (21, p <0.001). In CT image, there were significant decreases in mean lung density and the attenuation value separating the least 15% pixels (7.7 HU, p <0.001), but a significant increase in the percentage of the relative area of the lungs with attenuation values <-950 Hounsfield unit (1.9%, p <0.001). There were significant declines in smoking, modified Medical Research Council scale, Age-Dyspnea-Obstruction (ADO) index, Dyspnea-Obstruction-Smoking-Exacerbation (DOSE) index (all p <0.001), and exacerbation (p <0.01), but a significant increase in emphysema severity (p <0.05). This study shows the possible important change of HRCT in patients with emphysema following smoking cessation.

AB - The purpose of our study was to evaluate the short-term effect of changes in smoking cessation on subjects with chest high resolution computed tomography (HRCT)-diagnosed emphysema, both cross-sectionally and longitudinally. All patients participated in 3 months smoking cessation program.A detailed clinical history was taken and physical examination performed. We performed serum study, lung function testing and HRCT scanning to assess emphysema. After participation in the program, there was a significant increment in body mass index (0.88 kg/m2, p <0.001). There was a significant decline in forced expiratory volume in one second (3.0 % (33 ml), p <0.001), but smaller than decline in smokers. There was also a significant decline in C-reactive protein (0.40 mg/L, p <0.001) & St. George's Respiratory Questionnaire (21, p <0.001). In CT image, there were significant decreases in mean lung density and the attenuation value separating the least 15% pixels (7.7 HU, p <0.001), but a significant increase in the percentage of the relative area of the lungs with attenuation values <-950 Hounsfield unit (1.9%, p <0.001). There were significant declines in smoking, modified Medical Research Council scale, Age-Dyspnea-Obstruction (ADO) index, Dyspnea-Obstruction-Smoking-Exacerbation (DOSE) index (all p <0.001), and exacerbation (p <0.01), but a significant increase in emphysema severity (p <0.05). This study shows the possible important change of HRCT in patients with emphysema following smoking cessation.

KW - Emphysema

KW - High resolution computed tomography

KW - Mean lung density

KW - Percentile

KW - Relative area

KW - Smoking cessation

UR - http://www.scopus.com/inward/record.url?scp=84931091647&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84931091647&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84931091647

VL - 26

SP - 107

EP - 114

JO - Journal of Internal Medicine of Taiwan

JF - Journal of Internal Medicine of Taiwan

SN - 1016-7390

IS - 2

ER -