The high-frequency component of heart rate variability during extended wakefulness is closely associated with the depth of the ensuing sleep in C57BL6 mice

T. B.J. Kuo, C. T. Lai, C. Y. Chen, Y. C. Yang, C. C.H. Yang

Research output: Contribution to journalArticle

Abstract

This study aimed to test the hypothesis that, during extended wakefulness, parasympathetic activity is associated with the depth of the subsequent recovery sleep in mice. Fourteen male C57BL/6 mice were implanted with electrodes for sleep recording. Continuous spectral analysis was performed on the electroencephalogram (EEG) to obtain theta power (6-9 Hz) and delta power (0-4 Hz), as well as the R-R interval signals in order to quantify the high-frequency power (HF) and normalized low-frequency power (LF%) that are used to assess parasympathetic and sympathetic activity, respectively. All animals underwent a sleep deprivation experiment and a control experiment (6-h intervention and 1-h recovery period) on two separate days. During sleep deprivation, HF and theta power during wakefulness were significantly higher than during the control wakefulness after the second hour and first hour, respectively. During recovery non-rapid eye movement sleep, there was a rebound in sleep time and delta power as well as an elevation in HF relative to control post-intervention sleep. Both the rise in HF and theta power during extended wakefulness were found to be positively correlated with the delta power rebound. Furthermore, the HF change during extended wakefulness was also correlated with the amount of sleep loss and the enhancement of waking theta power. Our finding suggests that waking parasympathetic activity intimately reflects the cumulative sleep pressure, suggesting a potential role to be an autonomic marker for sleep propensity.

Original languageEnglish
Pages (from-to)257-266
Number of pages10
JournalNeuroscience
Volume330
DOIs
Publication statusPublished - Aug 25 2016
Externally publishedYes

Fingerprint

Wakefulness
Sleep
Heart Rate
Sleep Deprivation
Power (Psychology)
Implanted Electrodes
Eye Movements
Inbred C57BL Mouse
Electroencephalography

Keywords

  • Autonomic nervous system
  • Heart rate variability
  • Parasympathetic
  • Sleep propensity
  • Theta power
  • Vagal

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The high-frequency component of heart rate variability during extended wakefulness is closely associated with the depth of the ensuing sleep in C57BL6 mice. / Kuo, T. B.J.; Lai, C. T.; Chen, C. Y.; Yang, Y. C.; Yang, C. C.H.

In: Neuroscience, Vol. 330, 25.08.2016, p. 257-266.

Research output: Contribution to journalArticle

@article{e509de168a7843c7bafb91ea5b4c0fc4,
title = "The high-frequency component of heart rate variability during extended wakefulness is closely associated with the depth of the ensuing sleep in C57BL6 mice",
abstract = "This study aimed to test the hypothesis that, during extended wakefulness, parasympathetic activity is associated with the depth of the subsequent recovery sleep in mice. Fourteen male C57BL/6 mice were implanted with electrodes for sleep recording. Continuous spectral analysis was performed on the electroencephalogram (EEG) to obtain theta power (6-9 Hz) and delta power (0-4 Hz), as well as the R-R interval signals in order to quantify the high-frequency power (HF) and normalized low-frequency power (LF{\%}) that are used to assess parasympathetic and sympathetic activity, respectively. All animals underwent a sleep deprivation experiment and a control experiment (6-h intervention and 1-h recovery period) on two separate days. During sleep deprivation, HF and theta power during wakefulness were significantly higher than during the control wakefulness after the second hour and first hour, respectively. During recovery non-rapid eye movement sleep, there was a rebound in sleep time and delta power as well as an elevation in HF relative to control post-intervention sleep. Both the rise in HF and theta power during extended wakefulness were found to be positively correlated with the delta power rebound. Furthermore, the HF change during extended wakefulness was also correlated with the amount of sleep loss and the enhancement of waking theta power. Our finding suggests that waking parasympathetic activity intimately reflects the cumulative sleep pressure, suggesting a potential role to be an autonomic marker for sleep propensity.",
keywords = "Autonomic nervous system, Heart rate variability, Parasympathetic, Sleep propensity, Theta power, Vagal",
author = "Kuo, {T. B.J.} and Lai, {C. T.} and Chen, {C. Y.} and Yang, {Y. C.} and Yang, {C. C.H.}",
year = "2016",
month = "8",
day = "25",
doi = "10.1016/j.neuroscience.2016.05.060",
language = "English",
volume = "330",
pages = "257--266",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - The high-frequency component of heart rate variability during extended wakefulness is closely associated with the depth of the ensuing sleep in C57BL6 mice

AU - Kuo, T. B.J.

AU - Lai, C. T.

AU - Chen, C. Y.

AU - Yang, Y. C.

AU - Yang, C. C.H.

PY - 2016/8/25

Y1 - 2016/8/25

N2 - This study aimed to test the hypothesis that, during extended wakefulness, parasympathetic activity is associated with the depth of the subsequent recovery sleep in mice. Fourteen male C57BL/6 mice were implanted with electrodes for sleep recording. Continuous spectral analysis was performed on the electroencephalogram (EEG) to obtain theta power (6-9 Hz) and delta power (0-4 Hz), as well as the R-R interval signals in order to quantify the high-frequency power (HF) and normalized low-frequency power (LF%) that are used to assess parasympathetic and sympathetic activity, respectively. All animals underwent a sleep deprivation experiment and a control experiment (6-h intervention and 1-h recovery period) on two separate days. During sleep deprivation, HF and theta power during wakefulness were significantly higher than during the control wakefulness after the second hour and first hour, respectively. During recovery non-rapid eye movement sleep, there was a rebound in sleep time and delta power as well as an elevation in HF relative to control post-intervention sleep. Both the rise in HF and theta power during extended wakefulness were found to be positively correlated with the delta power rebound. Furthermore, the HF change during extended wakefulness was also correlated with the amount of sleep loss and the enhancement of waking theta power. Our finding suggests that waking parasympathetic activity intimately reflects the cumulative sleep pressure, suggesting a potential role to be an autonomic marker for sleep propensity.

AB - This study aimed to test the hypothesis that, during extended wakefulness, parasympathetic activity is associated with the depth of the subsequent recovery sleep in mice. Fourteen male C57BL/6 mice were implanted with electrodes for sleep recording. Continuous spectral analysis was performed on the electroencephalogram (EEG) to obtain theta power (6-9 Hz) and delta power (0-4 Hz), as well as the R-R interval signals in order to quantify the high-frequency power (HF) and normalized low-frequency power (LF%) that are used to assess parasympathetic and sympathetic activity, respectively. All animals underwent a sleep deprivation experiment and a control experiment (6-h intervention and 1-h recovery period) on two separate days. During sleep deprivation, HF and theta power during wakefulness were significantly higher than during the control wakefulness after the second hour and first hour, respectively. During recovery non-rapid eye movement sleep, there was a rebound in sleep time and delta power as well as an elevation in HF relative to control post-intervention sleep. Both the rise in HF and theta power during extended wakefulness were found to be positively correlated with the delta power rebound. Furthermore, the HF change during extended wakefulness was also correlated with the amount of sleep loss and the enhancement of waking theta power. Our finding suggests that waking parasympathetic activity intimately reflects the cumulative sleep pressure, suggesting a potential role to be an autonomic marker for sleep propensity.

KW - Autonomic nervous system

KW - Heart rate variability

KW - Parasympathetic

KW - Sleep propensity

KW - Theta power

KW - Vagal

UR - http://www.scopus.com/inward/record.url?scp=84974783010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84974783010&partnerID=8YFLogxK

U2 - 10.1016/j.neuroscience.2016.05.060

DO - 10.1016/j.neuroscience.2016.05.060

M3 - Article

VL - 330

SP - 257

EP - 266

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -