The ginsenoside rg1 rescues mitochondrial disorders in aristolochic acid‐induced nephropathic mice

Chu Kuang Chou, Yu Shen Huang, Pei Yu Lin, Kazuhiro Imai, Shih Ming Chen, Jen Ai Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic exposure to aristolochic acid (AA) leads to renal interstitial fibrosis and nephropathy. In this study, we aimed to investigate the renoprotective effects of Panax ginseng extract (GE) and ginsenoside saponin (GS) on AA‐induced nephropathy (AAN) in mice. Eighty female C3H/He mice were randomly divided into eight groups, including normal; AA (3 μg/mL for 56 days); AA with GE (125, 250, or 500 mg/kg/d for 14 days); and AA with important GE ingredients, Rg1, Rb1, or Rd (5 mg/kg/d for 14 days). Compared with the AA group, renal injuries were significantly decreased in the GE (250 mg/kg/d), Rb1, and Rg1 treatment groups. Rg1 exhibited the best renoprotection among all GS‐treated groups. There were 24 peaks significantly altered among normal, AA, and AA + Rg1 groups, and four mitochondrial proteins were identified, including acyl‐CoA synthetase medium‐chain family member 2, upregulated during skeletal muscle growth 5 (Usmg5), mitochondrial aconitase 2 (ACO2), and cytochrome c oxidase subunit Va preprotein (COX5a). We demonstrated for the first time that the AAN mechanism and renoprotective effects of Rg1 are associated with expression of mitochondrial proteins, especially ACO2, Usmg5, and COX5a.

Original languageEnglish
Article number1018
JournalLife
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 2021

Keywords

  • aristolochic acid
  • Ginsenoside
  • Mitochondrial disorder
  • Nephropathy
  • Rg1

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Space and Planetary Science
  • Palaeontology

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