The functions and regulations of DAPK in cancer metastasis

Hsin Yi Chen, Yu Ru Lee, Ruey Hwa Chen

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Metastasis is responsible for most cancer deaths but it remains a poorly understood process. Recent evidence has emerged that death-associated protein kinase (DAPK) is a candidate of metastasis suppressor. DAPK downregulation or inactivation has been observed in a number of metastatic cancers through epigenetic, transcriptional, post-transcriptional, or post-translational mechanism. In certain cases, DAPK downregulation correlates with metastatic recurrence. Animal studies further show that DAPK impedes both early-stage and late-stage metastatic process, which suggests that DAPK possesses multiple mechanisms to suppress metastasis. Cell-based studies revealed that DAPK mediates several types of cell death, including apoptosis, autophagic death and necrosis, depending on death stimuli and cell context. DAPK also regulates cytoskeleton proteins to mediate death-associated cell morphological alterations and to inhibit cell motility. Besides tumor cells, DAPK can influence on stromal cells to regulate their survival and functions. These effects likely all contribute to the metastasis suppressive role of DAPK. The detail molecular mechanisms of these anti-metastatic effects of DAPK are reviewed in this article.

Original languageEnglish
Pages (from-to)364-370
Number of pages7
JournalApoptosis
Volume19
Issue number2
DOIs
Publication statusPublished - Feb 2014

Fingerprint

Death-Associated Protein Kinases
Neoplasm Metastasis
Neoplasms
Cell Death
Cell death
Down-Regulation
Stromal Cells
Cytoskeleton
Epigenomics
Cell Movement
Tumors
Animals
Necrosis

Keywords

  • Cancer metastasis
  • Cell death
  • Cell motility
  • DAPK
  • Tumor suppressor

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Biochemistry, medical
  • Cancer Research
  • Pharmaceutical Science
  • Pharmacology

Cite this

The functions and regulations of DAPK in cancer metastasis. / Chen, Hsin Yi; Lee, Yu Ru; Chen, Ruey Hwa.

In: Apoptosis, Vol. 19, No. 2, 02.2014, p. 364-370.

Research output: Contribution to journalReview article

Chen, Hsin Yi ; Lee, Yu Ru ; Chen, Ruey Hwa. / The functions and regulations of DAPK in cancer metastasis. In: Apoptosis. 2014 ; Vol. 19, No. 2. pp. 364-370.
@article{8c3e5048cc634f338fcc904a56757274,
title = "The functions and regulations of DAPK in cancer metastasis",
abstract = "Metastasis is responsible for most cancer deaths but it remains a poorly understood process. Recent evidence has emerged that death-associated protein kinase (DAPK) is a candidate of metastasis suppressor. DAPK downregulation or inactivation has been observed in a number of metastatic cancers through epigenetic, transcriptional, post-transcriptional, or post-translational mechanism. In certain cases, DAPK downregulation correlates with metastatic recurrence. Animal studies further show that DAPK impedes both early-stage and late-stage metastatic process, which suggests that DAPK possesses multiple mechanisms to suppress metastasis. Cell-based studies revealed that DAPK mediates several types of cell death, including apoptosis, autophagic death and necrosis, depending on death stimuli and cell context. DAPK also regulates cytoskeleton proteins to mediate death-associated cell morphological alterations and to inhibit cell motility. Besides tumor cells, DAPK can influence on stromal cells to regulate their survival and functions. These effects likely all contribute to the metastasis suppressive role of DAPK. The detail molecular mechanisms of these anti-metastatic effects of DAPK are reviewed in this article.",
keywords = "Cancer metastasis, Cell death, Cell motility, DAPK, Tumor suppressor",
author = "Chen, {Hsin Yi} and Lee, {Yu Ru} and Chen, {Ruey Hwa}",
year = "2014",
month = "2",
doi = "10.1007/s10495-013-0923-6",
language = "English",
volume = "19",
pages = "364--370",
journal = "Apoptosis : an international journal on programmed cell death",
issn = "1360-8185",
publisher = "Springer Netherlands",
number = "2",

}

TY - JOUR

T1 - The functions and regulations of DAPK in cancer metastasis

AU - Chen, Hsin Yi

AU - Lee, Yu Ru

AU - Chen, Ruey Hwa

PY - 2014/2

Y1 - 2014/2

N2 - Metastasis is responsible for most cancer deaths but it remains a poorly understood process. Recent evidence has emerged that death-associated protein kinase (DAPK) is a candidate of metastasis suppressor. DAPK downregulation or inactivation has been observed in a number of metastatic cancers through epigenetic, transcriptional, post-transcriptional, or post-translational mechanism. In certain cases, DAPK downregulation correlates with metastatic recurrence. Animal studies further show that DAPK impedes both early-stage and late-stage metastatic process, which suggests that DAPK possesses multiple mechanisms to suppress metastasis. Cell-based studies revealed that DAPK mediates several types of cell death, including apoptosis, autophagic death and necrosis, depending on death stimuli and cell context. DAPK also regulates cytoskeleton proteins to mediate death-associated cell morphological alterations and to inhibit cell motility. Besides tumor cells, DAPK can influence on stromal cells to regulate their survival and functions. These effects likely all contribute to the metastasis suppressive role of DAPK. The detail molecular mechanisms of these anti-metastatic effects of DAPK are reviewed in this article.

AB - Metastasis is responsible for most cancer deaths but it remains a poorly understood process. Recent evidence has emerged that death-associated protein kinase (DAPK) is a candidate of metastasis suppressor. DAPK downregulation or inactivation has been observed in a number of metastatic cancers through epigenetic, transcriptional, post-transcriptional, or post-translational mechanism. In certain cases, DAPK downregulation correlates with metastatic recurrence. Animal studies further show that DAPK impedes both early-stage and late-stage metastatic process, which suggests that DAPK possesses multiple mechanisms to suppress metastasis. Cell-based studies revealed that DAPK mediates several types of cell death, including apoptosis, autophagic death and necrosis, depending on death stimuli and cell context. DAPK also regulates cytoskeleton proteins to mediate death-associated cell morphological alterations and to inhibit cell motility. Besides tumor cells, DAPK can influence on stromal cells to regulate their survival and functions. These effects likely all contribute to the metastasis suppressive role of DAPK. The detail molecular mechanisms of these anti-metastatic effects of DAPK are reviewed in this article.

KW - Cancer metastasis

KW - Cell death

KW - Cell motility

KW - DAPK

KW - Tumor suppressor

UR - http://www.scopus.com/inward/record.url?scp=84895037653&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895037653&partnerID=8YFLogxK

U2 - 10.1007/s10495-013-0923-6

DO - 10.1007/s10495-013-0923-6

M3 - Review article

C2 - 24166138

AN - SCOPUS:84895037653

VL - 19

SP - 364

EP - 370

JO - Apoptosis : an international journal on programmed cell death

JF - Apoptosis : an international journal on programmed cell death

SN - 1360-8185

IS - 2

ER -