The function of cyclic-adenosine monophosphate responsive element-binding protein in hematologic malignancies

Bryan Mitton, Er Chieh Cho, Grace I. Aldana-Masangkay, Kathleen M. Sakamoto

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Central to discovering novel approaches to treating leukemias and lymphomas is a clear understanding of the signaling networks which lead to unchecked cell cycle progression, proliferation, and survival. Cyclic-adenosine monophosphate (cAMP) responsive element-binding protein (CREB) represents a critical integrator of numerous signals from cytoplasmic kinase cascades, and is directly involved in controlling the transcription of genes critical for normal cellular proliferation and survival. Several lines of evidence implicate CREB as a proto-oncogene, as a number of translocations involving CREB and dysregulation of expression are both associated with oncogenesis. Thus, CREB represents a potential therapeutic target in leukemia. Here, we review CREB function and regulation in normal and aberrant hematopoiesis.

Original languageEnglish
Pages (from-to)2057-2063
Number of pages7
JournalLeukemia and Lymphoma
Volume52
Issue number11
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Cell cycle and apoptosis changes
  • Lymphoid leukemia
  • Myeloid leukemias and dysplasias
  • Signal transduction
  • Transcription factor changes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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