The expression of type I growth factor receptors in the squamous neoplastic changes of uterine cervix

Junn Liang Chang, Yeou Ping Tsao, Dai Wei Liu, Chih Ping Han, Wei Hwa Lee, Show Li Chen

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Aim. The type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In this study, we systematically investigated the frequency and distribution of these four receptors in relation to neoplastic changes and tumor behaviors in the uterine cervix. Materials. A total 84 of cases including 12 cases of normal cervical tissues, 6 cases of low grade squamous intraepithelial lesion, 10 cases of high grade squamous intraepithelial lesion, and 56 cases of squamous cells carcinoma were examined. Results. Our results show significant difference with increasing grades of dysplasia in terms of these four receptor expressions. No association was found between these four receptors and cell keratinization/differentiation of squamous cell carcinoma of the cervix. Of the four receptors studied, only the expression of erbB2/neu gene was significantly associated with lymph nodal metastasis. Moreover, we find that the coexpression of ErbB1 and ErbB4 was significant in cervical carcinoma. Conclusions. The coexpression of ErbB1 and ErbB4 in cervical carcinoma suggests that they may be involved in receptor heterodimerization leading to the activation of signaling pathway in the cervical carcinoma.

Original languageEnglish
Pages (from-to)62-71
Number of pages10
JournalGynecologic Oncology
Volume73
Issue number1
DOIs
Publication statusPublished - Apr 1999
Externally publishedYes

Fingerprint

Growth Factor Receptors
Cervix Uteri
erbB-2 Genes
Carcinoma
Squamous Cell Carcinoma
Lymph
Cell Differentiation
Neoplasms
Neoplasm Metastasis
Squamous Intraepithelial Lesions of the Cervix

Keywords

  • Cervical carcinoma
  • Growth factor receptor
  • Immunohistochemistry

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

The expression of type I growth factor receptors in the squamous neoplastic changes of uterine cervix. / Chang, Junn Liang; Tsao, Yeou Ping; Liu, Dai Wei; Han, Chih Ping; Lee, Wei Hwa; Chen, Show Li.

In: Gynecologic Oncology, Vol. 73, No. 1, 04.1999, p. 62-71.

Research output: Contribution to journalArticle

Chang, Junn Liang ; Tsao, Yeou Ping ; Liu, Dai Wei ; Han, Chih Ping ; Lee, Wei Hwa ; Chen, Show Li. / The expression of type I growth factor receptors in the squamous neoplastic changes of uterine cervix. In: Gynecologic Oncology. 1999 ; Vol. 73, No. 1. pp. 62-71.
@article{63f70755710142d19ef4e946654f46e5,
title = "The expression of type I growth factor receptors in the squamous neoplastic changes of uterine cervix",
abstract = "Aim. The type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In this study, we systematically investigated the frequency and distribution of these four receptors in relation to neoplastic changes and tumor behaviors in the uterine cervix. Materials. A total 84 of cases including 12 cases of normal cervical tissues, 6 cases of low grade squamous intraepithelial lesion, 10 cases of high grade squamous intraepithelial lesion, and 56 cases of squamous cells carcinoma were examined. Results. Our results show significant difference with increasing grades of dysplasia in terms of these four receptor expressions. No association was found between these four receptors and cell keratinization/differentiation of squamous cell carcinoma of the cervix. Of the four receptors studied, only the expression of erbB2/neu gene was significantly associated with lymph nodal metastasis. Moreover, we find that the coexpression of ErbB1 and ErbB4 was significant in cervical carcinoma. Conclusions. The coexpression of ErbB1 and ErbB4 in cervical carcinoma suggests that they may be involved in receptor heterodimerization leading to the activation of signaling pathway in the cervical carcinoma.",
keywords = "Cervical carcinoma, Growth factor receptor, Immunohistochemistry",
author = "Chang, {Junn Liang} and Tsao, {Yeou Ping} and Liu, {Dai Wei} and Han, {Chih Ping} and Lee, {Wei Hwa} and Chen, {Show Li}",
year = "1999",
month = "4",
doi = "10.1006/gyno.1998.5301",
language = "English",
volume = "73",
pages = "62--71",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - The expression of type I growth factor receptors in the squamous neoplastic changes of uterine cervix

AU - Chang, Junn Liang

AU - Tsao, Yeou Ping

AU - Liu, Dai Wei

AU - Han, Chih Ping

AU - Lee, Wei Hwa

AU - Chen, Show Li

PY - 1999/4

Y1 - 1999/4

N2 - Aim. The type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In this study, we systematically investigated the frequency and distribution of these four receptors in relation to neoplastic changes and tumor behaviors in the uterine cervix. Materials. A total 84 of cases including 12 cases of normal cervical tissues, 6 cases of low grade squamous intraepithelial lesion, 10 cases of high grade squamous intraepithelial lesion, and 56 cases of squamous cells carcinoma were examined. Results. Our results show significant difference with increasing grades of dysplasia in terms of these four receptor expressions. No association was found between these four receptors and cell keratinization/differentiation of squamous cell carcinoma of the cervix. Of the four receptors studied, only the expression of erbB2/neu gene was significantly associated with lymph nodal metastasis. Moreover, we find that the coexpression of ErbB1 and ErbB4 was significant in cervical carcinoma. Conclusions. The coexpression of ErbB1 and ErbB4 in cervical carcinoma suggests that they may be involved in receptor heterodimerization leading to the activation of signaling pathway in the cervical carcinoma.

AB - Aim. The type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In this study, we systematically investigated the frequency and distribution of these four receptors in relation to neoplastic changes and tumor behaviors in the uterine cervix. Materials. A total 84 of cases including 12 cases of normal cervical tissues, 6 cases of low grade squamous intraepithelial lesion, 10 cases of high grade squamous intraepithelial lesion, and 56 cases of squamous cells carcinoma were examined. Results. Our results show significant difference with increasing grades of dysplasia in terms of these four receptor expressions. No association was found between these four receptors and cell keratinization/differentiation of squamous cell carcinoma of the cervix. Of the four receptors studied, only the expression of erbB2/neu gene was significantly associated with lymph nodal metastasis. Moreover, we find that the coexpression of ErbB1 and ErbB4 was significant in cervical carcinoma. Conclusions. The coexpression of ErbB1 and ErbB4 in cervical carcinoma suggests that they may be involved in receptor heterodimerization leading to the activation of signaling pathway in the cervical carcinoma.

KW - Cervical carcinoma

KW - Growth factor receptor

KW - Immunohistochemistry

UR - http://www.scopus.com/inward/record.url?scp=0032894071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032894071&partnerID=8YFLogxK

U2 - 10.1006/gyno.1998.5301

DO - 10.1006/gyno.1998.5301

M3 - Article

C2 - 10094882

AN - SCOPUS:0032894071

VL - 73

SP - 62

EP - 71

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 1

ER -