Abstract
Aim. The type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In this study, we systematically investigated the frequency and distribution of these four receptors in relation to neoplastic changes and tumor behaviors in the uterine cervix. Materials. A total 84 of cases including 12 cases of normal cervical tissues, 6 cases of low grade squamous intraepithelial lesion, 10 cases of high grade squamous intraepithelial lesion, and 56 cases of squamous cells carcinoma were examined. Results. Our results show significant difference with increasing grades of dysplasia in terms of these four receptor expressions. No association was found between these four receptors and cell keratinization/differentiation of squamous cell carcinoma of the cervix. Of the four receptors studied, only the expression of erbB2/neu gene was significantly associated with lymph nodal metastasis. Moreover, we find that the coexpression of ErbB1 and ErbB4 was significant in cervical carcinoma. Conclusions. The coexpression of ErbB1 and ErbB4 in cervical carcinoma suggests that they may be involved in receptor heterodimerization leading to the activation of signaling pathway in the cervical carcinoma.
| Original language | English |
|---|---|
| Pages (from-to) | 62-71 |
| Number of pages | 10 |
| Journal | Gynecologic Oncology |
| Volume | 73 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Apr 1999 |
| Externally published | Yes |
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Keywords
- Cervical carcinoma
- Growth factor receptor
- Immunohistochemistry
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Oncology
Cite this
The expression of type I growth factor receptors in the squamous neoplastic changes of uterine cervix. / Chang, Junn Liang; Tsao, Yeou Ping; Liu, Dai Wei; Han, Chih Ping; Lee, Wei Hwa; Chen, Show Li.
In: Gynecologic Oncology, Vol. 73, No. 1, 04.1999, p. 62-71.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The expression of type I growth factor receptors in the squamous neoplastic changes of uterine cervix
AU - Chang, Junn Liang
AU - Tsao, Yeou Ping
AU - Liu, Dai Wei
AU - Han, Chih Ping
AU - Lee, Wei Hwa
AU - Chen, Show Li
PY - 1999/4
Y1 - 1999/4
N2 - Aim. The type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In this study, we systematically investigated the frequency and distribution of these four receptors in relation to neoplastic changes and tumor behaviors in the uterine cervix. Materials. A total 84 of cases including 12 cases of normal cervical tissues, 6 cases of low grade squamous intraepithelial lesion, 10 cases of high grade squamous intraepithelial lesion, and 56 cases of squamous cells carcinoma were examined. Results. Our results show significant difference with increasing grades of dysplasia in terms of these four receptor expressions. No association was found between these four receptors and cell keratinization/differentiation of squamous cell carcinoma of the cervix. Of the four receptors studied, only the expression of erbB2/neu gene was significantly associated with lymph nodal metastasis. Moreover, we find that the coexpression of ErbB1 and ErbB4 was significant in cervical carcinoma. Conclusions. The coexpression of ErbB1 and ErbB4 in cervical carcinoma suggests that they may be involved in receptor heterodimerization leading to the activation of signaling pathway in the cervical carcinoma.
AB - Aim. The type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In this study, we systematically investigated the frequency and distribution of these four receptors in relation to neoplastic changes and tumor behaviors in the uterine cervix. Materials. A total 84 of cases including 12 cases of normal cervical tissues, 6 cases of low grade squamous intraepithelial lesion, 10 cases of high grade squamous intraepithelial lesion, and 56 cases of squamous cells carcinoma were examined. Results. Our results show significant difference with increasing grades of dysplasia in terms of these four receptor expressions. No association was found between these four receptors and cell keratinization/differentiation of squamous cell carcinoma of the cervix. Of the four receptors studied, only the expression of erbB2/neu gene was significantly associated with lymph nodal metastasis. Moreover, we find that the coexpression of ErbB1 and ErbB4 was significant in cervical carcinoma. Conclusions. The coexpression of ErbB1 and ErbB4 in cervical carcinoma suggests that they may be involved in receptor heterodimerization leading to the activation of signaling pathway in the cervical carcinoma.
KW - Cervical carcinoma
KW - Growth factor receptor
KW - Immunohistochemistry
UR - http://www.scopus.com/inward/record.url?scp=0032894071&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032894071&partnerID=8YFLogxK
U2 - 10.1006/gyno.1998.5301
DO - 10.1006/gyno.1998.5301
M3 - Article
C2 - 10094882
AN - SCOPUS:0032894071
VL - 73
SP - 62
EP - 71
JO - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 1
ER -