The estimation of first-phase insulin secretion by using components of the metabolic syndrome in a Chinese population

Jiunn Diann Lin, Chun Hsien Hsu, Yao Jen Liang, Wei Cheng Lian, Chang Hsun Hsieh, Chung Ze Wu, Dee Pei, Yen Lin Chen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aims. There are two phases of insulin secretion, the first (FPIS) and second phase (SPIS). In this study, we built equations to predict FPIS with metabolic syndrome (MetS) components and fasting plasma insulin (FPI). Methods. Totally, 186 participants were enrolled. 75% of participants were randomly selected as the study group to build equations. The remaining 25% of participants were selected as the external validation group. All participants received a frequently sampled intravenous glucose tolerance test, and acute insulin response after the glucose load (AIRg) was obtained. The AIRg was considered as FPIS. Results. When MetS components were only used, the following equation was built: log (FPIS) = 1.477-0.119 × fasting plasma glucose (FPG) + 0.079 × body mass index (BMI)-0.523 × high-density lipoprotein cholesterol (HDL-C). After FPI was added, the second equation was formulated: log (FPIS) = 1.532-0.127 × FPG + 0.059 × BMI-0.511 × HDL-C + 0.375 × log (FPI), which provided a better accuracy than the first one. Conclusions. Using MetS components, the FPIS could be estimated accurately. After adding FPI into the equation, the predictive power increased further. We hope that these equations could be widely used in daily practice.

Original languageEnglish
Article number675245
JournalInternational Journal of Endocrinology
Volume2015
DOIs
Publication statusPublished - 2015

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Fasting
Insulin
Population
Glucose
HDL Cholesterol
Body Mass Index
Glucose Tolerance Test

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

The estimation of first-phase insulin secretion by using components of the metabolic syndrome in a Chinese population. / Lin, Jiunn Diann; Hsu, Chun Hsien; Liang, Yao Jen; Lian, Wei Cheng; Hsieh, Chang Hsun; Wu, Chung Ze; Pei, Dee; Chen, Yen Lin.

In: International Journal of Endocrinology, Vol. 2015, 675245, 2015.

Research output: Contribution to journalArticle

Lin, Jiunn Diann ; Hsu, Chun Hsien ; Liang, Yao Jen ; Lian, Wei Cheng ; Hsieh, Chang Hsun ; Wu, Chung Ze ; Pei, Dee ; Chen, Yen Lin. / The estimation of first-phase insulin secretion by using components of the metabolic syndrome in a Chinese population. In: International Journal of Endocrinology. 2015 ; Vol. 2015.
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AU - Hsieh, Chang Hsun

AU - Wu, Chung Ze

AU - Pei, Dee

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