The epidemiology and burden of Alzheimer’s disease in Taiwan utilizing data from the National Health Insurance Research Database

Yen Ni Hung, Zbigniew Kadziola, Alan J M Brnabic, Ju Fen Yeh, Jong Ling Fuh, Jen Ping Hwang, William Montgomery

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: The objectives of this study were to estimate the incidence, cumulative incidence, and economic burden of Alzheimer’s disease (AD) in Taiwan, using data from the National Health Insurance Research Database (NHIRD). Materials and methods: This was a retrospective, longitudinal, observational study using data from the Longitudinal Health Insurance Database of the NHIRD. Patients were included in this study if they were 50 years of age or older and their records included a primary or secondary diagnosis of AD. New patients who met inclusion criteria were followed up longitudinally from 2005 to 2010. Costs were calculated for the first year following the diagnosis of AD. Results: Overall, a higher percentage of women than men were diagnosed with AD (54% vs 46%, respectively). The first AD diagnosis occurred most frequently in the age of 75-84 years. The person-year incidence rate increased from 5.63/1,000 persons (95% CI, 5.32-5.94) in 2005 to 8.17/1,000 persons (95% CI, 7.78-8.57) in 2010. The cumulative incidence rate was 33.54/1,000 persons (95% CI, 32.76-34.33) in 2005-2010. The total mean inflated annual costs per patient in new Taiwan dollars (NT$) in the first year of diagnosis ranged from NT$205,413 (2009) to NT$227,110 (2005), with hospitalization representing the largest component. Conclusion: AD represents a substantial burden in Taiwan, and based on the observed increase in incidence rate over time, it is likely that this burden will continue to increase. The findings reported here are consistent with previous research. The NHIRD contains extensive real-world information that can be used to conduct research, allowing us to expand our understanding of the incidence, prevalence, and burden of disease in Taiwan.

Original languageEnglish
Pages (from-to)387-395
Number of pages9
JournalClinicoEconomics and Outcomes Research
Volume8
DOIs
Publication statusPublished - Aug 2 2016

Fingerprint

National Health Programs
Taiwan
Alzheimer Disease
Epidemiology
Databases
Incidence
Research
Costs and Cost Analysis
Cost of Illness
Health Insurance
Observational Studies
Longitudinal Studies
Burden
Data base
National health insurance
Alzheimer's disease
Hospitalization

Keywords

  • Alzheimer’s disease
  • Incidence
  • Medical costs
  • Resource utilization

ASJC Scopus subject areas

  • Economics, Econometrics and Finance (miscellaneous)
  • Health Policy

Cite this

The epidemiology and burden of Alzheimer’s disease in Taiwan utilizing data from the National Health Insurance Research Database. / Hung, Yen Ni; Kadziola, Zbigniew; Brnabic, Alan J M; Yeh, Ju Fen; Fuh, Jong Ling; Hwang, Jen Ping; Montgomery, William.

In: ClinicoEconomics and Outcomes Research, Vol. 8, 02.08.2016, p. 387-395.

Research output: Contribution to journalArticle

Hung, Yen Ni ; Kadziola, Zbigniew ; Brnabic, Alan J M ; Yeh, Ju Fen ; Fuh, Jong Ling ; Hwang, Jen Ping ; Montgomery, William. / The epidemiology and burden of Alzheimer’s disease in Taiwan utilizing data from the National Health Insurance Research Database. In: ClinicoEconomics and Outcomes Research. 2016 ; Vol. 8. pp. 387-395.
@article{75afbfb280384e87bda45cf0b4eb4bbc,
title = "The epidemiology and burden of Alzheimer’s disease in Taiwan utilizing data from the National Health Insurance Research Database",
abstract = "Purpose: The objectives of this study were to estimate the incidence, cumulative incidence, and economic burden of Alzheimer’s disease (AD) in Taiwan, using data from the National Health Insurance Research Database (NHIRD). Materials and methods: This was a retrospective, longitudinal, observational study using data from the Longitudinal Health Insurance Database of the NHIRD. Patients were included in this study if they were 50 years of age or older and their records included a primary or secondary diagnosis of AD. New patients who met inclusion criteria were followed up longitudinally from 2005 to 2010. Costs were calculated for the first year following the diagnosis of AD. Results: Overall, a higher percentage of women than men were diagnosed with AD (54{\%} vs 46{\%}, respectively). The first AD diagnosis occurred most frequently in the age of 75-84 years. The person-year incidence rate increased from 5.63/1,000 persons (95{\%} CI, 5.32-5.94) in 2005 to 8.17/1,000 persons (95{\%} CI, 7.78-8.57) in 2010. The cumulative incidence rate was 33.54/1,000 persons (95{\%} CI, 32.76-34.33) in 2005-2010. The total mean inflated annual costs per patient in new Taiwan dollars (NT$) in the first year of diagnosis ranged from NT$205,413 (2009) to NT$227,110 (2005), with hospitalization representing the largest component. Conclusion: AD represents a substantial burden in Taiwan, and based on the observed increase in incidence rate over time, it is likely that this burden will continue to increase. The findings reported here are consistent with previous research. The NHIRD contains extensive real-world information that can be used to conduct research, allowing us to expand our understanding of the incidence, prevalence, and burden of disease in Taiwan.",
keywords = "Alzheimer’s disease, Incidence, Medical costs, Resource utilization",
author = "Hung, {Yen Ni} and Zbigniew Kadziola and Brnabic, {Alan J M} and Yeh, {Ju Fen} and Fuh, {Jong Ling} and Hwang, {Jen Ping} and William Montgomery",
year = "2016",
month = "8",
day = "2",
doi = "10.2147/CEOR.S93323",
language = "English",
volume = "8",
pages = "387--395",
journal = "ClinicoEconomics and Outcomes Research",
issn = "1178-6981",
publisher = "Dove Medical Press Limited",

}

TY - JOUR

T1 - The epidemiology and burden of Alzheimer’s disease in Taiwan utilizing data from the National Health Insurance Research Database

AU - Hung, Yen Ni

AU - Kadziola, Zbigniew

AU - Brnabic, Alan J M

AU - Yeh, Ju Fen

AU - Fuh, Jong Ling

AU - Hwang, Jen Ping

AU - Montgomery, William

PY - 2016/8/2

Y1 - 2016/8/2

N2 - Purpose: The objectives of this study were to estimate the incidence, cumulative incidence, and economic burden of Alzheimer’s disease (AD) in Taiwan, using data from the National Health Insurance Research Database (NHIRD). Materials and methods: This was a retrospective, longitudinal, observational study using data from the Longitudinal Health Insurance Database of the NHIRD. Patients were included in this study if they were 50 years of age or older and their records included a primary or secondary diagnosis of AD. New patients who met inclusion criteria were followed up longitudinally from 2005 to 2010. Costs were calculated for the first year following the diagnosis of AD. Results: Overall, a higher percentage of women than men were diagnosed with AD (54% vs 46%, respectively). The first AD diagnosis occurred most frequently in the age of 75-84 years. The person-year incidence rate increased from 5.63/1,000 persons (95% CI, 5.32-5.94) in 2005 to 8.17/1,000 persons (95% CI, 7.78-8.57) in 2010. The cumulative incidence rate was 33.54/1,000 persons (95% CI, 32.76-34.33) in 2005-2010. The total mean inflated annual costs per patient in new Taiwan dollars (NT$) in the first year of diagnosis ranged from NT$205,413 (2009) to NT$227,110 (2005), with hospitalization representing the largest component. Conclusion: AD represents a substantial burden in Taiwan, and based on the observed increase in incidence rate over time, it is likely that this burden will continue to increase. The findings reported here are consistent with previous research. The NHIRD contains extensive real-world information that can be used to conduct research, allowing us to expand our understanding of the incidence, prevalence, and burden of disease in Taiwan.

AB - Purpose: The objectives of this study were to estimate the incidence, cumulative incidence, and economic burden of Alzheimer’s disease (AD) in Taiwan, using data from the National Health Insurance Research Database (NHIRD). Materials and methods: This was a retrospective, longitudinal, observational study using data from the Longitudinal Health Insurance Database of the NHIRD. Patients were included in this study if they were 50 years of age or older and their records included a primary or secondary diagnosis of AD. New patients who met inclusion criteria were followed up longitudinally from 2005 to 2010. Costs were calculated for the first year following the diagnosis of AD. Results: Overall, a higher percentage of women than men were diagnosed with AD (54% vs 46%, respectively). The first AD diagnosis occurred most frequently in the age of 75-84 years. The person-year incidence rate increased from 5.63/1,000 persons (95% CI, 5.32-5.94) in 2005 to 8.17/1,000 persons (95% CI, 7.78-8.57) in 2010. The cumulative incidence rate was 33.54/1,000 persons (95% CI, 32.76-34.33) in 2005-2010. The total mean inflated annual costs per patient in new Taiwan dollars (NT$) in the first year of diagnosis ranged from NT$205,413 (2009) to NT$227,110 (2005), with hospitalization representing the largest component. Conclusion: AD represents a substantial burden in Taiwan, and based on the observed increase in incidence rate over time, it is likely that this burden will continue to increase. The findings reported here are consistent with previous research. The NHIRD contains extensive real-world information that can be used to conduct research, allowing us to expand our understanding of the incidence, prevalence, and burden of disease in Taiwan.

KW - Alzheimer’s disease

KW - Incidence

KW - Medical costs

KW - Resource utilization

UR - http://www.scopus.com/inward/record.url?scp=84988981520&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988981520&partnerID=8YFLogxK

U2 - 10.2147/CEOR.S93323

DO - 10.2147/CEOR.S93323

M3 - Article

AN - SCOPUS:84988981520

VL - 8

SP - 387

EP - 395

JO - ClinicoEconomics and Outcomes Research

JF - ClinicoEconomics and Outcomes Research

SN - 1178-6981

ER -