The eosinophilic variant of acute myelomonocytic leukemia developing as a secondary leukemia in a patient with mycosis fungoides

D. B. Jones, F. Kaye, J. Hardman, J. Whang-Peng, N. L. Dale, D. F. Garvin, H. R. Schumacher

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The eosinophilic variant of acute myelomonocytic leukemia (AMML) is highly associated with characteristic abnormalities of chromosome 16. Leukemias developing secondary to chemotherapy frequently show abnormalities of chromosomes 5 and 7. This report describes a secondary AMML, eosinophilic variant (M4Eo), developing in a patient with coexistent mycosis fungoides who had received chemotherapy, including an alkylating agent, and showing characteristic abnormalities of both chromosomes 7 and 16. This is the first reported case of the M4Eo arising secondarily in a patient treated for another hematopoietic malignancy, and the second case of treatment-induced M4Eo to show coexistent abnormalities of chromosomes 7 and 16. Additional cytochemical, ultrastructural, and cell surface marker findings are described supporting malignant transformation of the eosinophilic cell line.

Original languageEnglish
Pages (from-to)67-76
Number of pages10
JournalHematologic Pathology
Volume1
Issue number1
Publication statusPublished - Dec 1 1987
Externally publishedYes

Fingerprint

Leukemia, Myelomonocytic, Acute
Chromosomes, Human, Pair 16
Mycosis Fungoides
Chromosomes, Human, Pair 7
Leukemia
Drug Therapy
Chromosomes, Human, Pair 5
Alkylating Agents
Hematologic Neoplasms
Cell Line
Therapeutics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Hematology

Cite this

Jones, D. B., Kaye, F., Hardman, J., Whang-Peng, J., Dale, N. L., Garvin, D. F., & Schumacher, H. R. (1987). The eosinophilic variant of acute myelomonocytic leukemia developing as a secondary leukemia in a patient with mycosis fungoides. Hematologic Pathology, 1(1), 67-76.

The eosinophilic variant of acute myelomonocytic leukemia developing as a secondary leukemia in a patient with mycosis fungoides. / Jones, D. B.; Kaye, F.; Hardman, J.; Whang-Peng, J.; Dale, N. L.; Garvin, D. F.; Schumacher, H. R.

In: Hematologic Pathology, Vol. 1, No. 1, 01.12.1987, p. 67-76.

Research output: Contribution to journalArticle

Jones, D. B. ; Kaye, F. ; Hardman, J. ; Whang-Peng, J. ; Dale, N. L. ; Garvin, D. F. ; Schumacher, H. R. / The eosinophilic variant of acute myelomonocytic leukemia developing as a secondary leukemia in a patient with mycosis fungoides. In: Hematologic Pathology. 1987 ; Vol. 1, No. 1. pp. 67-76.
@article{5575492baf1d46f2b24b8b1e994f15e7,
title = "The eosinophilic variant of acute myelomonocytic leukemia developing as a secondary leukemia in a patient with mycosis fungoides",
abstract = "The eosinophilic variant of acute myelomonocytic leukemia (AMML) is highly associated with characteristic abnormalities of chromosome 16. Leukemias developing secondary to chemotherapy frequently show abnormalities of chromosomes 5 and 7. This report describes a secondary AMML, eosinophilic variant (M4Eo), developing in a patient with coexistent mycosis fungoides who had received chemotherapy, including an alkylating agent, and showing characteristic abnormalities of both chromosomes 7 and 16. This is the first reported case of the M4Eo arising secondarily in a patient treated for another hematopoietic malignancy, and the second case of treatment-induced M4Eo to show coexistent abnormalities of chromosomes 7 and 16. Additional cytochemical, ultrastructural, and cell surface marker findings are described supporting malignant transformation of the eosinophilic cell line.",
author = "Jones, {D. B.} and F. Kaye and J. Hardman and J. Whang-Peng and Dale, {N. L.} and Garvin, {D. F.} and Schumacher, {H. R.}",
year = "1987",
month = "12",
day = "1",
language = "English",
volume = "1",
pages = "67--76",
journal = "Hematologic Pathology",
issn = "0886-0238",
publisher = "Marcel Dekker Inc.",
number = "1",

}

TY - JOUR

T1 - The eosinophilic variant of acute myelomonocytic leukemia developing as a secondary leukemia in a patient with mycosis fungoides

AU - Jones, D. B.

AU - Kaye, F.

AU - Hardman, J.

AU - Whang-Peng, J.

AU - Dale, N. L.

AU - Garvin, D. F.

AU - Schumacher, H. R.

PY - 1987/12/1

Y1 - 1987/12/1

N2 - The eosinophilic variant of acute myelomonocytic leukemia (AMML) is highly associated with characteristic abnormalities of chromosome 16. Leukemias developing secondary to chemotherapy frequently show abnormalities of chromosomes 5 and 7. This report describes a secondary AMML, eosinophilic variant (M4Eo), developing in a patient with coexistent mycosis fungoides who had received chemotherapy, including an alkylating agent, and showing characteristic abnormalities of both chromosomes 7 and 16. This is the first reported case of the M4Eo arising secondarily in a patient treated for another hematopoietic malignancy, and the second case of treatment-induced M4Eo to show coexistent abnormalities of chromosomes 7 and 16. Additional cytochemical, ultrastructural, and cell surface marker findings are described supporting malignant transformation of the eosinophilic cell line.

AB - The eosinophilic variant of acute myelomonocytic leukemia (AMML) is highly associated with characteristic abnormalities of chromosome 16. Leukemias developing secondary to chemotherapy frequently show abnormalities of chromosomes 5 and 7. This report describes a secondary AMML, eosinophilic variant (M4Eo), developing in a patient with coexistent mycosis fungoides who had received chemotherapy, including an alkylating agent, and showing characteristic abnormalities of both chromosomes 7 and 16. This is the first reported case of the M4Eo arising secondarily in a patient treated for another hematopoietic malignancy, and the second case of treatment-induced M4Eo to show coexistent abnormalities of chromosomes 7 and 16. Additional cytochemical, ultrastructural, and cell surface marker findings are described supporting malignant transformation of the eosinophilic cell line.

UR - http://www.scopus.com/inward/record.url?scp=0023584227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023584227&partnerID=8YFLogxK

M3 - Article

C2 - 3504431

AN - SCOPUS:0023584227

VL - 1

SP - 67

EP - 76

JO - Hematologic Pathology

JF - Hematologic Pathology

SN - 0886-0238

IS - 1

ER -