The eosinophilic variant of acute myelomonocytic leukemia developing as a secondary leukemia in a patient with mycosis fungoides

D. B. Jones, F. Kaye, J. Hardman, J. Whang-Peng, N. L. Dale, D. F. Garvin, H. R. Schumacher

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The eosinophilic variant of acute myelomonocytic leukemia (AMML) is highly associated with characteristic abnormalities of chromosome 16. Leukemias developing secondary to chemotherapy frequently show abnormalities of chromosomes 5 and 7. This report describes a secondary AMML, eosinophilic variant (M4Eo), developing in a patient with coexistent mycosis fungoides who had received chemotherapy, including an alkylating agent, and showing characteristic abnormalities of both chromosomes 7 and 16. This is the first reported case of the M4Eo arising secondarily in a patient treated for another hematopoietic malignancy, and the second case of treatment-induced M4Eo to show coexistent abnormalities of chromosomes 7 and 16. Additional cytochemical, ultrastructural, and cell surface marker findings are described supporting malignant transformation of the eosinophilic cell line.

Original languageEnglish
Pages (from-to)67-76
Number of pages10
JournalHematologic Pathology
Volume1
Issue number1
Publication statusPublished - Dec 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Hematology

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  • Cite this

    Jones, D. B., Kaye, F., Hardman, J., Whang-Peng, J., Dale, N. L., Garvin, D. F., & Schumacher, H. R. (1987). The eosinophilic variant of acute myelomonocytic leukemia developing as a secondary leukemia in a patient with mycosis fungoides. Hematologic Pathology, 1(1), 67-76.