The emergence of HIV-1 circulating recombinant form 07_BC strains in Taiwan

Sheng Fan Wang, IYu Ting Lin, Yen Ju Chen, Yi Ming Arthur Chen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

There was an outbreak of human immunodeficiency virus type 1 (HIV-1) circulating recombinant form (CRF) 07_BC among injection drug users (IDUs) in Taiwan in 2004. In this chapter, we described a molecular epidemiological analysis of HIV-1 in Taiwan and further characterized the full length genome of the Taiwanese CRF07_BC. DNA sequencing and phylogenetic analysis were conducted to determine subtypes and evolutionary relationships. Recombination breakpoints of 2 full-length CRF07_BC strains were elucidated using a bootscanning method. Of 206 HIV-1-infected patients who received a diagnosis in 2004, 44.7% were infected with subtype B, 53.4% with CRF07_BC, and 1.5% with CRF01_AE. Ninety-eight percent (109/111) of IDUs were infected with CRF07_BC. Deletions of 7-11 amino acids in both p6gag and p6pol proteins were noted among the Taiwanese CRF07_BC strains. The CRF_07BC strains belonged to 2 phylogenetic clusters, and the first cluster contained only CRF07_BC strains from the southern part of Taiwan. The Taiwanese CRF07_BC strains had 97% full-length sequence homology with the prototype from mainland China. CRF07_BC was first introduced into the southern region in 2002 and then has been disseminated to other regions in Taiwan since 2004.

Original languageEnglish
Title of host publicationHandbook of Disease Outbreaks
Subtitle of host publicationPrevention, Detection and Control
PublisherNova Science Publishers, Inc.
Pages321-334
Number of pages14
ISBN (Print)9781608762248
Publication statusPublished - Dec 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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