The emergence in Taiwan of fluoroquinolone resistance in Salmonella enterica serotype choleraesuis

Cheng Hsun Chiu, Tsu Lan Wu, Lin Hui Su, Chishih Chu, Ju Hsin Chia, An Jing Kuo, Maw Sheng Chien, Tzou Yien Lin

Research output: Contribution to journalArticle

200 Citations (Scopus)

Abstract

Background: Salmonella enterica serotype choleraesuis is a cause of serious systemic infections. Because fluoroquinolones are the drug of choice for the treatment of severe salmonella infections, the emergence and dissemination of fluoroquinolone-resistant S. enterica serotype choleraesuis have clinical consequences. Methods: In Taiwan, a hospital-based surveillance system has been in place since 1987 to monitor the incidence of S. enterica serotype choleraesuis infections and the antimicrobial susceptibility of the isolates. We investigated the rapid emergence of fluoroquinolone resistance in this serotype in 2000 and 2001. Pigs in Taiwan were evaluated as a potential source of the resistant salmonella. Results: A total of 501 clinical isolates of S. enterica serotype choleraesuis were recovered in our hospital from 1987 through 2000. The proportion of total salmonella isolates made up by S. enterica serotype choleraesuis decreased from an average of 8.4 percent before 1995 to 2.7 percent in 1996 through 1998. During 1999 and 2000, this proportion increased significantly, to an average of 5.0 percent. Ciprofloxacin resistance in S. enterica serotype choleraesuis has been observed since 2000. In the third quarter of 2001, 60 percent of isolates were resistant to ciprofloxacin. Molecular typing indicated that the primary source of S. enterica serotype choleraesuis isolates was herds of swine. All the resistant isolates from humans and swine had mutations that led to the substitution of phenylalanine for serine at position 83 and asparagine for aspartic acid at position 87 in the gene for DNA gyrase A. Conclusions: This investigation in Taiwan indicates that fluoroquinolone-resistant S. enterica serotype choleraesuis can spread from swine to humans. The use of fluoroquinolones in food animals should be prohibited.

Original languageEnglish
Pages (from-to)413-419
Number of pages7
JournalNew England Journal of Medicine
Volume346
Issue number6
DOIs
Publication statusPublished - Feb 7 2002
Externally publishedYes

Fingerprint

Salmonella enterica
Fluoroquinolones
Taiwan
Swine
Ciprofloxacin
Salmonella
DNA Gyrase
Serogroup
Molecular Typing
Salmonella Infections
Asparagine
Infection
Phenylalanine
Aspartic Acid
Serine
Food
Mutation
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The emergence in Taiwan of fluoroquinolone resistance in Salmonella enterica serotype choleraesuis. / Chiu, Cheng Hsun; Wu, Tsu Lan; Su, Lin Hui; Chu, Chishih; Chia, Ju Hsin; Kuo, An Jing; Chien, Maw Sheng; Lin, Tzou Yien.

In: New England Journal of Medicine, Vol. 346, No. 6, 07.02.2002, p. 413-419.

Research output: Contribution to journalArticle

Chiu, Cheng Hsun ; Wu, Tsu Lan ; Su, Lin Hui ; Chu, Chishih ; Chia, Ju Hsin ; Kuo, An Jing ; Chien, Maw Sheng ; Lin, Tzou Yien. / The emergence in Taiwan of fluoroquinolone resistance in Salmonella enterica serotype choleraesuis. In: New England Journal of Medicine. 2002 ; Vol. 346, No. 6. pp. 413-419.
@article{cc7176c177e34beca1e542523152a1b5,
title = "The emergence in Taiwan of fluoroquinolone resistance in Salmonella enterica serotype choleraesuis",
abstract = "Background: Salmonella enterica serotype choleraesuis is a cause of serious systemic infections. Because fluoroquinolones are the drug of choice for the treatment of severe salmonella infections, the emergence and dissemination of fluoroquinolone-resistant S. enterica serotype choleraesuis have clinical consequences. Methods: In Taiwan, a hospital-based surveillance system has been in place since 1987 to monitor the incidence of S. enterica serotype choleraesuis infections and the antimicrobial susceptibility of the isolates. We investigated the rapid emergence of fluoroquinolone resistance in this serotype in 2000 and 2001. Pigs in Taiwan were evaluated as a potential source of the resistant salmonella. Results: A total of 501 clinical isolates of S. enterica serotype choleraesuis were recovered in our hospital from 1987 through 2000. The proportion of total salmonella isolates made up by S. enterica serotype choleraesuis decreased from an average of 8.4 percent before 1995 to 2.7 percent in 1996 through 1998. During 1999 and 2000, this proportion increased significantly, to an average of 5.0 percent. Ciprofloxacin resistance in S. enterica serotype choleraesuis has been observed since 2000. In the third quarter of 2001, 60 percent of isolates were resistant to ciprofloxacin. Molecular typing indicated that the primary source of S. enterica serotype choleraesuis isolates was herds of swine. All the resistant isolates from humans and swine had mutations that led to the substitution of phenylalanine for serine at position 83 and asparagine for aspartic acid at position 87 in the gene for DNA gyrase A. Conclusions: This investigation in Taiwan indicates that fluoroquinolone-resistant S. enterica serotype choleraesuis can spread from swine to humans. The use of fluoroquinolones in food animals should be prohibited.",
author = "Chiu, {Cheng Hsun} and Wu, {Tsu Lan} and Su, {Lin Hui} and Chishih Chu and Chia, {Ju Hsin} and Kuo, {An Jing} and Chien, {Maw Sheng} and Lin, {Tzou Yien}",
year = "2002",
month = "2",
day = "7",
doi = "10.1056/NEJMoa012261",
language = "English",
volume = "346",
pages = "413--419",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "6",

}

TY - JOUR

T1 - The emergence in Taiwan of fluoroquinolone resistance in Salmonella enterica serotype choleraesuis

AU - Chiu, Cheng Hsun

AU - Wu, Tsu Lan

AU - Su, Lin Hui

AU - Chu, Chishih

AU - Chia, Ju Hsin

AU - Kuo, An Jing

AU - Chien, Maw Sheng

AU - Lin, Tzou Yien

PY - 2002/2/7

Y1 - 2002/2/7

N2 - Background: Salmonella enterica serotype choleraesuis is a cause of serious systemic infections. Because fluoroquinolones are the drug of choice for the treatment of severe salmonella infections, the emergence and dissemination of fluoroquinolone-resistant S. enterica serotype choleraesuis have clinical consequences. Methods: In Taiwan, a hospital-based surveillance system has been in place since 1987 to monitor the incidence of S. enterica serotype choleraesuis infections and the antimicrobial susceptibility of the isolates. We investigated the rapid emergence of fluoroquinolone resistance in this serotype in 2000 and 2001. Pigs in Taiwan were evaluated as a potential source of the resistant salmonella. Results: A total of 501 clinical isolates of S. enterica serotype choleraesuis were recovered in our hospital from 1987 through 2000. The proportion of total salmonella isolates made up by S. enterica serotype choleraesuis decreased from an average of 8.4 percent before 1995 to 2.7 percent in 1996 through 1998. During 1999 and 2000, this proportion increased significantly, to an average of 5.0 percent. Ciprofloxacin resistance in S. enterica serotype choleraesuis has been observed since 2000. In the third quarter of 2001, 60 percent of isolates were resistant to ciprofloxacin. Molecular typing indicated that the primary source of S. enterica serotype choleraesuis isolates was herds of swine. All the resistant isolates from humans and swine had mutations that led to the substitution of phenylalanine for serine at position 83 and asparagine for aspartic acid at position 87 in the gene for DNA gyrase A. Conclusions: This investigation in Taiwan indicates that fluoroquinolone-resistant S. enterica serotype choleraesuis can spread from swine to humans. The use of fluoroquinolones in food animals should be prohibited.

AB - Background: Salmonella enterica serotype choleraesuis is a cause of serious systemic infections. Because fluoroquinolones are the drug of choice for the treatment of severe salmonella infections, the emergence and dissemination of fluoroquinolone-resistant S. enterica serotype choleraesuis have clinical consequences. Methods: In Taiwan, a hospital-based surveillance system has been in place since 1987 to monitor the incidence of S. enterica serotype choleraesuis infections and the antimicrobial susceptibility of the isolates. We investigated the rapid emergence of fluoroquinolone resistance in this serotype in 2000 and 2001. Pigs in Taiwan were evaluated as a potential source of the resistant salmonella. Results: A total of 501 clinical isolates of S. enterica serotype choleraesuis were recovered in our hospital from 1987 through 2000. The proportion of total salmonella isolates made up by S. enterica serotype choleraesuis decreased from an average of 8.4 percent before 1995 to 2.7 percent in 1996 through 1998. During 1999 and 2000, this proportion increased significantly, to an average of 5.0 percent. Ciprofloxacin resistance in S. enterica serotype choleraesuis has been observed since 2000. In the third quarter of 2001, 60 percent of isolates were resistant to ciprofloxacin. Molecular typing indicated that the primary source of S. enterica serotype choleraesuis isolates was herds of swine. All the resistant isolates from humans and swine had mutations that led to the substitution of phenylalanine for serine at position 83 and asparagine for aspartic acid at position 87 in the gene for DNA gyrase A. Conclusions: This investigation in Taiwan indicates that fluoroquinolone-resistant S. enterica serotype choleraesuis can spread from swine to humans. The use of fluoroquinolones in food animals should be prohibited.

UR - http://www.scopus.com/inward/record.url?scp=0037034263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037034263&partnerID=8YFLogxK

U2 - 10.1056/NEJMoa012261

DO - 10.1056/NEJMoa012261

M3 - Article

VL - 346

SP - 413

EP - 419

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 6

ER -