The efficacy of blueberry and grape seed extract combination on triple therapy for Helicobacter pylori eradication: A randomised controlled trial

Chian Sem Chua, Kuo-Ching Yang, Jui Hao Chen, Yuh Hwa Liu, Yi Hsin Hsu, Hsiu Chuan Lee, Shih-Yi Huang

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2 Citations (Scopus)


Helicobacter pylori is a major risk factor for gastritis, gastric ulcers and gastric cancer. Traditional therapy with proton pump inhibitor and antibiotics is regarded as optimal for H. pylori eradication whereas, the eradication rate is unsatisfactory. Studies have reported that cranberry may inhibit H. pylori adhesion to the human gastric mucus but lack of other berry extracts have been evaluated in clinical study. Thus, a 9-week add-on randomised controlled trial was conducted to explore the impact of blueberry and grape seed extract (BGE) combinations traditional therapy for H. pylori eradication. In results, we found that there was no significant difference of eradication rate between the berry extract group and placebo group in the intention-to-treat analysis and in the per-protocol analysis (94.64% versus 84.62%, p=0.085). Diarrhoea, constipation and epigastric pain were observed increasing during ingestion of the berry extract in some cases. In conclusion, this study indicated that no significant difference existed between the BGE extract group and placebo group in eradication rate under triple therapy.

Original languageEnglish
Pages (from-to)177-183
Number of pages7
JournalInternational Journal of Food Sciences and Nutrition
Issue number2
Publication statusPublished - Jan 1 2016



  • Blueberry extract
  • Grape seed extracts
  • Helicobacter pylori
  • Polyphenol

ASJC Scopus subject areas

  • Food Science

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