The effects of metabolic syndrome versus infectious burden on inflammation, severity of coronary atherosclerosis, and major adverse cardiovascular events

Dao Fu Dai, Jou Wei Lin, Jia Horng Kao, Chih Neng Hsu, Fu Tien Chiang, Jiunn Lee Lin, Yi Hua Chou, Kwan Lih Hsu, Chuen Den Tseng, Yung Zu Tseng, Juey Jen Hwang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: The clinical predictors of inflammation in atherosclerosis remain controversial. The objective of this study was to compare the associations of metabolic factors vs. infectious burden (IB) with inflammation, the severity of coronary atherosclerosis, and major adverse cardiovascular events (MACEs). Design, Setting, and Patients: Coronary angiography with Gensini score was applied to assess the severity of coronary atherosclerosis in 568 patients with coronary artery disease. Metabolic syndrome (MS) score (0-5) was defined according to the modified criteria of National Cholesterol Education Program Adult Treatment Panel III. IB score (0-7) was defined as the number of seropositivities to several agents. Results: IB score was not associated with plasma C-reactive protein (CRP) concentration, Gensini score, or the risk of MACE. In contrast, MS score significantly correlated with both plasma CRP concentration and Gensini score (P < 0.001 for both). MS score and plasma CRP concentration were also significantly associated with the risk of MACE (hazard ratios 1.51, P < 0.001; and 1.90, P = 0.002, respectively). Conclusion: Compared with IB, metabolic abnormalities have a more prominent association with the degree of inflammation, the severity of coronary atherosclerosis, and the risk of MACE in patients with coronary artery disease.

Original languageEnglish
Pages (from-to)2532-2537
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume92
Issue number7
DOIs
Publication statusPublished - Jan 1 2007
Externally publishedYes

Fingerprint

C-Reactive Protein
Coronary Artery Disease
Inflammation
Plasmas
Blood Proteins
Angiography
Hazards
Education
Cholesterol
Coronary Angiography
Atherosclerosis
Therapeutics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

The effects of metabolic syndrome versus infectious burden on inflammation, severity of coronary atherosclerosis, and major adverse cardiovascular events. / Dai, Dao Fu; Lin, Jou Wei; Kao, Jia Horng; Hsu, Chih Neng; Chiang, Fu Tien; Lin, Jiunn Lee; Chou, Yi Hua; Hsu, Kwan Lih; Tseng, Chuen Den; Tseng, Yung Zu; Hwang, Juey Jen.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 92, No. 7, 01.01.2007, p. 2532-2537.

Research output: Contribution to journalArticle

Dai, Dao Fu ; Lin, Jou Wei ; Kao, Jia Horng ; Hsu, Chih Neng ; Chiang, Fu Tien ; Lin, Jiunn Lee ; Chou, Yi Hua ; Hsu, Kwan Lih ; Tseng, Chuen Den ; Tseng, Yung Zu ; Hwang, Juey Jen. / The effects of metabolic syndrome versus infectious burden on inflammation, severity of coronary atherosclerosis, and major adverse cardiovascular events. In: Journal of Clinical Endocrinology and Metabolism. 2007 ; Vol. 92, No. 7. pp. 2532-2537.
@article{51958dae209244e79e3c4539a00cb1ff,
title = "The effects of metabolic syndrome versus infectious burden on inflammation, severity of coronary atherosclerosis, and major adverse cardiovascular events",
abstract = "Background: The clinical predictors of inflammation in atherosclerosis remain controversial. The objective of this study was to compare the associations of metabolic factors vs. infectious burden (IB) with inflammation, the severity of coronary atherosclerosis, and major adverse cardiovascular events (MACEs). Design, Setting, and Patients: Coronary angiography with Gensini score was applied to assess the severity of coronary atherosclerosis in 568 patients with coronary artery disease. Metabolic syndrome (MS) score (0-5) was defined according to the modified criteria of National Cholesterol Education Program Adult Treatment Panel III. IB score (0-7) was defined as the number of seropositivities to several agents. Results: IB score was not associated with plasma C-reactive protein (CRP) concentration, Gensini score, or the risk of MACE. In contrast, MS score significantly correlated with both plasma CRP concentration and Gensini score (P < 0.001 for both). MS score and plasma CRP concentration were also significantly associated with the risk of MACE (hazard ratios 1.51, P < 0.001; and 1.90, P = 0.002, respectively). Conclusion: Compared with IB, metabolic abnormalities have a more prominent association with the degree of inflammation, the severity of coronary atherosclerosis, and the risk of MACE in patients with coronary artery disease.",
keywords = "C reactive protein, angiocardiography, cardiovascular disease, coronary artery atherosclerosis",
author = "Dai, {Dao Fu} and Lin, {Jou Wei} and Kao, {Jia Horng} and Hsu, {Chih Neng} and Chiang, {Fu Tien} and Lin, {Jiunn Lee} and Chou, {Yi Hua} and Hsu, {Kwan Lih} and Tseng, {Chuen Den} and Tseng, {Yung Zu} and Hwang, {Juey Jen}",
year = "2007",
month = "1",
day = "1",
doi = "10.1210/jc.2006-2428",
language = "English",
volume = "92",
pages = "2532--2537",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "7",

}

TY - JOUR

T1 - The effects of metabolic syndrome versus infectious burden on inflammation, severity of coronary atherosclerosis, and major adverse cardiovascular events

AU - Dai, Dao Fu

AU - Lin, Jou Wei

AU - Kao, Jia Horng

AU - Hsu, Chih Neng

AU - Chiang, Fu Tien

AU - Lin, Jiunn Lee

AU - Chou, Yi Hua

AU - Hsu, Kwan Lih

AU - Tseng, Chuen Den

AU - Tseng, Yung Zu

AU - Hwang, Juey Jen

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Background: The clinical predictors of inflammation in atherosclerosis remain controversial. The objective of this study was to compare the associations of metabolic factors vs. infectious burden (IB) with inflammation, the severity of coronary atherosclerosis, and major adverse cardiovascular events (MACEs). Design, Setting, and Patients: Coronary angiography with Gensini score was applied to assess the severity of coronary atherosclerosis in 568 patients with coronary artery disease. Metabolic syndrome (MS) score (0-5) was defined according to the modified criteria of National Cholesterol Education Program Adult Treatment Panel III. IB score (0-7) was defined as the number of seropositivities to several agents. Results: IB score was not associated with plasma C-reactive protein (CRP) concentration, Gensini score, or the risk of MACE. In contrast, MS score significantly correlated with both plasma CRP concentration and Gensini score (P < 0.001 for both). MS score and plasma CRP concentration were also significantly associated with the risk of MACE (hazard ratios 1.51, P < 0.001; and 1.90, P = 0.002, respectively). Conclusion: Compared with IB, metabolic abnormalities have a more prominent association with the degree of inflammation, the severity of coronary atherosclerosis, and the risk of MACE in patients with coronary artery disease.

AB - Background: The clinical predictors of inflammation in atherosclerosis remain controversial. The objective of this study was to compare the associations of metabolic factors vs. infectious burden (IB) with inflammation, the severity of coronary atherosclerosis, and major adverse cardiovascular events (MACEs). Design, Setting, and Patients: Coronary angiography with Gensini score was applied to assess the severity of coronary atherosclerosis in 568 patients with coronary artery disease. Metabolic syndrome (MS) score (0-5) was defined according to the modified criteria of National Cholesterol Education Program Adult Treatment Panel III. IB score (0-7) was defined as the number of seropositivities to several agents. Results: IB score was not associated with plasma C-reactive protein (CRP) concentration, Gensini score, or the risk of MACE. In contrast, MS score significantly correlated with both plasma CRP concentration and Gensini score (P < 0.001 for both). MS score and plasma CRP concentration were also significantly associated with the risk of MACE (hazard ratios 1.51, P < 0.001; and 1.90, P = 0.002, respectively). Conclusion: Compared with IB, metabolic abnormalities have a more prominent association with the degree of inflammation, the severity of coronary atherosclerosis, and the risk of MACE in patients with coronary artery disease.

KW - C reactive protein

KW - angiocardiography

KW - cardiovascular disease

KW - coronary artery atherosclerosis

UR - http://www.scopus.com/inward/record.url?scp=34447120214&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447120214&partnerID=8YFLogxK

U2 - 10.1210/jc.2006-2428

DO - 10.1210/jc.2006-2428

M3 - Article

VL - 92

SP - 2532

EP - 2537

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 7

ER -