The effects of lazaroid U-74389G in a rat sepsis model

Yun Te Chang, Shue Ren Wann, Kai Hseng Hsieh, Yung Ching Liu, Ching Hsiung Chang, Mu Shun Huang, Chun I. Huang, Hong Tai Chang

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4 Citations (Scopus)

Abstract

Objective and design: To examine the protective effects of a lazaroid, 21-aminosteroid U-74389G, in a rat septic shock model. Materials or subjects: Male Sprague-Dawley rats (n = 60) aged 6-8 months. Treatment: Groups were exposed to 500 cGy radiation followed by E. coli inoculation, and either placebo or lazaroid injection (10 mg/kg intraperitoneal) 5 days after irradiation. Methods: Hemodynamic measurements, arterial blood gases, serum lactate, total antioxidative capacity, and cytokine levels were measured at specific time intervals. Results: Treatment with the lazaroid U-74389G maintained cardiac output and mean aortic pressure. Lazaroid treatment also prevented the increase in serum lactate seen in placebo-treated rats. Cytokine serum levels in lazaroid-treated rats were not significantly different from those in placebo-treated rats at any time point. Conclusions: Lazaroid treatment of E. coli-inoculated septic animals lessens the hemodynamic deterioration seen in sepsis.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalInflammation Research
Volume60
Issue number1
DOIs
Publication statusPublished - Jan 2011
Externally publishedYes

Keywords

  • Cardiac output
  • Cytokines
  • E. coli
  • Lactate
  • Septic shock

ASJC Scopus subject areas

  • Pharmacology
  • Immunology

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  • Cite this

    Chang, Y. T., Wann, S. R., Hsieh, K. H., Liu, Y. C., Chang, C. H., Huang, M. S., Huang, C. I., & Chang, H. T. (2011). The effects of lazaroid U-74389G in a rat sepsis model. Inflammation Research, 60(1), 29-35. https://doi.org/10.1007/s00011-010-0231-3