The effects of lazaroid U-74389G in a rat sepsis model

Yun Te Chang, Shue Ren Wann, Kai Hseng Hsieh, Yung Ching Liu, Ching Hsiung Chang, Mu Shun Huang, Chun I. Huang, Hong Tai Chang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective and design: To examine the protective effects of a lazaroid, 21-aminosteroid U-74389G, in a rat septic shock model. Materials or subjects: Male Sprague-Dawley rats (n = 60) aged 6-8 months. Treatment: Groups were exposed to 500 cGy radiation followed by E. coli inoculation, and either placebo or lazaroid injection (10 mg/kg intraperitoneal) 5 days after irradiation. Methods: Hemodynamic measurements, arterial blood gases, serum lactate, total antioxidative capacity, and cytokine levels were measured at specific time intervals. Results: Treatment with the lazaroid U-74389G maintained cardiac output and mean aortic pressure. Lazaroid treatment also prevented the increase in serum lactate seen in placebo-treated rats. Cytokine serum levels in lazaroid-treated rats were not significantly different from those in placebo-treated rats at any time point. Conclusions: Lazaroid treatment of E. coli-inoculated septic animals lessens the hemodynamic deterioration seen in sepsis.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalInflammation Research
Volume60
Issue number1
DOIs
Publication statusPublished - Jan 2011
Externally publishedYes

Fingerprint

Sepsis
Placebos
Lactic Acid
Hemodynamics
Serum
Cytokines
Escherichia coli
Therapeutics
Septic Shock
Cardiac Output
Sprague Dawley Rats
Arterial Pressure
Gases
Radiation
Injections
U 74389F

Keywords

  • Cardiac output
  • Cytokines
  • E. coli
  • Lactate
  • Septic shock

ASJC Scopus subject areas

  • Pharmacology
  • Immunology

Cite this

Chang, Y. T., Wann, S. R., Hsieh, K. H., Liu, Y. C., Chang, C. H., Huang, M. S., ... Chang, H. T. (2011). The effects of lazaroid U-74389G in a rat sepsis model. Inflammation Research, 60(1), 29-35. https://doi.org/10.1007/s00011-010-0231-3

The effects of lazaroid U-74389G in a rat sepsis model. / Chang, Yun Te; Wann, Shue Ren; Hsieh, Kai Hseng; Liu, Yung Ching; Chang, Ching Hsiung; Huang, Mu Shun; Huang, Chun I.; Chang, Hong Tai.

In: Inflammation Research, Vol. 60, No. 1, 01.2011, p. 29-35.

Research output: Contribution to journalArticle

Chang, YT, Wann, SR, Hsieh, KH, Liu, YC, Chang, CH, Huang, MS, Huang, CI & Chang, HT 2011, 'The effects of lazaroid U-74389G in a rat sepsis model', Inflammation Research, vol. 60, no. 1, pp. 29-35. https://doi.org/10.1007/s00011-010-0231-3
Chang, Yun Te ; Wann, Shue Ren ; Hsieh, Kai Hseng ; Liu, Yung Ching ; Chang, Ching Hsiung ; Huang, Mu Shun ; Huang, Chun I. ; Chang, Hong Tai. / The effects of lazaroid U-74389G in a rat sepsis model. In: Inflammation Research. 2011 ; Vol. 60, No. 1. pp. 29-35.
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