The effects of electrically assisted methods on transdermal delivery of nalbuphine benzoate and sebacoyl dinalbuphine ester from solutions and hydrogels

Jeng Fen Huang, K. C. Sung, Oliver Yoa Pu Hu, Jhi Joung Wang, Yi Hsin Lin, Jia You Fang

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The aim of this study was to assess the effects of iontophoresis and electroporation on transdermal delivery of nalbuphine (NA) and its two novel prodrugs: nalbuphine benzoate (NAB) and sebacoyl dinalbuphine ester (SDN) from solutions as well as from hydrogels. Hydroxypropyl cellulose (HPC) and carboxymethyl cellulose (CMC) were used in hydrogel formulations to evaluate their feasibility for delivery of NA and its prodrugs. Application of iontophoresis or electroporation significantly enhanced the in vitro permeation of NA and its prodrugs. The enhancement effect was more pronounced after applying iontophoresis. The combination of two electrically assisted methods enhanced the delivery of NA; however, no such enhancement was observed for the permeation of NAB and SDN. Hydrogels containing low concentration HPC did not affect the passive as well as electrically assisted permeation of NA and its prodrugs. The increase of hydrogel concentration as well as molecular weight significantly decreased the electrically assisted permeation of NA, whereas the permeation of NAB and SDN remained unchanged. For the electrically assisted permeation from CMC-based hydrogels, the reduced permeation from higher percentage of CMC hydrogels may be attributed the viscosity effect as well as the ion competition effect. The above results demonstrated that lipophilicity and molecular size, as well as hydrogel compositions had significant effects on skin permeation of NA, NAB and SDN via passive diffusion or under the electric field.

Original languageEnglish
Pages (from-to)162-171
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume297
Issue number1-2
DOIs
Publication statusPublished - Jun 13 2005
Externally publishedYes

Fingerprint

Nalbuphine
Hydrogels
Benzoates
Prodrugs
Iontophoresis
Carboxymethylcellulose Sodium
Hydrogel
Electroporation
sebacoyl dinalbuphine ester
Viscosity

Keywords

  • Electroporation
  • Hydrogels
  • Iontophoresis
  • Nalbuphine
  • Prodrugs
  • Transdermal delivery

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

The effects of electrically assisted methods on transdermal delivery of nalbuphine benzoate and sebacoyl dinalbuphine ester from solutions and hydrogels. / Huang, Jeng Fen; Sung, K. C.; Hu, Oliver Yoa Pu; Wang, Jhi Joung; Lin, Yi Hsin; Fang, Jia You.

In: International Journal of Pharmaceutics, Vol. 297, No. 1-2, 13.06.2005, p. 162-171.

Research output: Contribution to journalArticle

Huang, Jeng Fen ; Sung, K. C. ; Hu, Oliver Yoa Pu ; Wang, Jhi Joung ; Lin, Yi Hsin ; Fang, Jia You. / The effects of electrically assisted methods on transdermal delivery of nalbuphine benzoate and sebacoyl dinalbuphine ester from solutions and hydrogels. In: International Journal of Pharmaceutics. 2005 ; Vol. 297, No. 1-2. pp. 162-171.
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