The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults

Kai J. Chuang, Chang Chuan Chan, Ta Chen Su, Chung T. Lee, Chin Sheng Tang

Research output: Contribution to journalArticle

368 Citations (Scopus)

Abstract

Rationale: The biological mechanisms linking air pollution to cardiovascular events still remain largerly unclear. Objectives: To investigate whether biological mechanisms linking air pollution to cardiovascular events occurred concurrently in human subjects exposed to urban air pollutants. Methods: We recruited a panel of 76 young, healthy students from a university in Taipei. Between April and June of 2004 or 2005, three measurements were made in each participant of high-sensitivity Creactive protein (hs-CRP), 8-hydroxy-2′-deoxyguanosine (8-OHdG), plasminogen activator fibrinogen inhibitor-1 (PAI-1), tissue-type plasminogen activator (tPA) in plasma, and heart rate variability (HRV). Gaseous air pollutants were measured at one air-monitoring station inside their campus, and particulate air pollutants were measured at one particulate matter supersite monitoring station 1 km from their campus.Weused linear mixed-effects models to associate biological endpoints with individual air pollutants averaged over 1- to 3-day periods before measurements were performed. Measurements and Main Results: We found that increases in hs-CRP, 8-OHdG, fibrinogen, and PAI-1, and decreases in HRV indices were associated with increases in levels of particles with aerodynamic diameters less than 10 μm and 2.5 μm, sulfate, nitrate, and ozone (O3) in single-pollutant models. The increase in 8-OHdG, fibrinogen, and PAI-1, and the reduction in HRV remained significantly associated with 3-day averaged sulfate and O3 levels in two-pollutant models. There were moderate correlations (r = -0.3) between blood markers of hs-CRP, fibrinogen, PAI-1, and HRV indices. Conclusions: Urban air pollution is associated with inflammation, oxidative stress, blood coagulation and autonomic dysfunction simultaneously in healthy young humans, with sulfate and O3 as two major traffic-related pollutants contributing to such effects.

Original languageEnglish
Pages (from-to)370-376
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume176
Issue number4
DOIs
Publication statusPublished - Aug 15 2007
Externally publishedYes

Fingerprint

Air Pollution
Fibrinogen
Young Adult
Oxidative Stress
Inflammation
Plasminogen Activator Inhibitor 1
Air Pollutants
Heart Rate
Sulfates
Particulate Matter
Proteins
Ozone
Blood Coagulation
Tissue Plasminogen Activator
Nitrates
Air
Students

Keywords

  • Air pollution
  • Blood coagulation
  • Heart rate variability
  • Inflammation
  • Oxidative stress

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults. / Chuang, Kai J.; Chan, Chang Chuan; Su, Ta Chen; Lee, Chung T.; Tang, Chin Sheng.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 176, No. 4, 15.08.2007, p. 370-376.

Research output: Contribution to journalArticle

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AU - Su, Ta Chen

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AU - Tang, Chin Sheng

PY - 2007/8/15

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N2 - Rationale: The biological mechanisms linking air pollution to cardiovascular events still remain largerly unclear. Objectives: To investigate whether biological mechanisms linking air pollution to cardiovascular events occurred concurrently in human subjects exposed to urban air pollutants. Methods: We recruited a panel of 76 young, healthy students from a university in Taipei. Between April and June of 2004 or 2005, three measurements were made in each participant of high-sensitivity Creactive protein (hs-CRP), 8-hydroxy-2′-deoxyguanosine (8-OHdG), plasminogen activator fibrinogen inhibitor-1 (PAI-1), tissue-type plasminogen activator (tPA) in plasma, and heart rate variability (HRV). Gaseous air pollutants were measured at one air-monitoring station inside their campus, and particulate air pollutants were measured at one particulate matter supersite monitoring station 1 km from their campus.Weused linear mixed-effects models to associate biological endpoints with individual air pollutants averaged over 1- to 3-day periods before measurements were performed. Measurements and Main Results: We found that increases in hs-CRP, 8-OHdG, fibrinogen, and PAI-1, and decreases in HRV indices were associated with increases in levels of particles with aerodynamic diameters less than 10 μm and 2.5 μm, sulfate, nitrate, and ozone (O3) in single-pollutant models. The increase in 8-OHdG, fibrinogen, and PAI-1, and the reduction in HRV remained significantly associated with 3-day averaged sulfate and O3 levels in two-pollutant models. There were moderate correlations (r = -0.3) between blood markers of hs-CRP, fibrinogen, PAI-1, and HRV indices. Conclusions: Urban air pollution is associated with inflammation, oxidative stress, blood coagulation and autonomic dysfunction simultaneously in healthy young humans, with sulfate and O3 as two major traffic-related pollutants contributing to such effects.

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KW - Air pollution

KW - Blood coagulation

KW - Heart rate variability

KW - Inflammation

KW - Oxidative stress

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