The effect of temperature and standings can cause deviations in prostate specific antigen (PSA) assays

Chiu Lan Hsieh, Ching Yuan Chang, Wang Sheng Ko, Bor Shah Chen, Kuan Chou Chen, Robert Y. Peng

Research output: Contribution to journalArticle


Blood samples were assayed for PSA values immediately after sampled or by standing for an assigned period. Variation of the free- (f), total- (t) values, and the free to total (f/t) ratios were determined. Mathematical models were used to interpret the phenomena of deviation. Smaller values of PSA values changed randomly with time and temperature of standings, resulting in varying f/t ratios, while larger initial PSA values were relatively unaffected to any significant extent. Model interpreted that the changes of PSA values might be caused by higher temperature and time of standings, and conformational participation was also possible.

Original languageEnglish
Pages (from-to)2485-2496
Number of pages12
JournalAnalytical Letters
Issue number13
Publication statusPublished - Jan 2007



  • Assay of PSA
  • Mathematical model
  • Prostate specific antigen (PSA)

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

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