The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats

Paul Chan, De Yi Xu, Ju Chi Liu, Yi Jen Chen, Brian Tomlinson, Wen Pin Huang, Juei Tang Cheng

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Stevioside is a sweet-tasting glycoside, composed of stevia, a diterpenic carboxylic alcohol with three glucose molecules, mainly used as a substitute for non-alcoholic sweetener. It has previously been shown to reduce blood pressure in studies in animals and human. The effect of intravenous stevioside on the blood pressure was studied in spontaneously hypertensive rats (SHR). The hypotensive effect on both systolic and diastolic blood pressure was dose-dependent for intravenous doses of 50, 100 and 200 mg/kg in conscious SHR. The maximum reductions in systolic and diastolic blood pressure were 31.4 ± 4.2% and 40.8 ± 5.6% (mean ± SEM) respectively and the hypotensive effect lasted for more than 60 min with a dose of 200 mg/kg. Serum dopamine, norepinephrine and epinephrine levels were not changed significantly 60 min after intravenous injection of stevioside 100 mg/kg in anesthetized SHR. The present data show that stevioside given intravenously to conscious SHR was effective in blood pressure reduction and there was no change in serum catecholamines in anaesthetized animals with this natural compound.

Original languageEnglish
Pages (from-to)1679-1684
Number of pages6
JournalLife Sciences
Volume63
Issue number19
DOIs
Publication statusPublished - Oct 2 1998

Fingerprint

Blood pressure
Inbred SHR Rats
Catecholamines
Rats
Blood Pressure
Plasmas
Animals
Sweetening Agents
Stevia
Glycosides
Epinephrine
Dopamine
Norepinephrine
Alcohols
stevioside
Serum
Intravenous Injections
Glucose
Scanning electron microscopy
Molecules

Keywords

  • Blood pressure
  • Plasma catecholamines
  • Spontaneously hypertensive rat
  • Stevioside

ASJC Scopus subject areas

  • Pharmacology

Cite this

The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. / Chan, Paul; Xu, De Yi; Liu, Ju Chi; Chen, Yi Jen; Tomlinson, Brian; Huang, Wen Pin; Cheng, Juei Tang.

In: Life Sciences, Vol. 63, No. 19, 02.10.1998, p. 1679-1684.

Research output: Contribution to journalArticle

Chan, Paul ; Xu, De Yi ; Liu, Ju Chi ; Chen, Yi Jen ; Tomlinson, Brian ; Huang, Wen Pin ; Cheng, Juei Tang. / The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. In: Life Sciences. 1998 ; Vol. 63, No. 19. pp. 1679-1684.
@article{3e7d10ea04624477b06774664910f667,
title = "The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats",
abstract = "Stevioside is a sweet-tasting glycoside, composed of stevia, a diterpenic carboxylic alcohol with three glucose molecules, mainly used as a substitute for non-alcoholic sweetener. It has previously been shown to reduce blood pressure in studies in animals and human. The effect of intravenous stevioside on the blood pressure was studied in spontaneously hypertensive rats (SHR). The hypotensive effect on both systolic and diastolic blood pressure was dose-dependent for intravenous doses of 50, 100 and 200 mg/kg in conscious SHR. The maximum reductions in systolic and diastolic blood pressure were 31.4 ± 4.2{\%} and 40.8 ± 5.6{\%} (mean ± SEM) respectively and the hypotensive effect lasted for more than 60 min with a dose of 200 mg/kg. Serum dopamine, norepinephrine and epinephrine levels were not changed significantly 60 min after intravenous injection of stevioside 100 mg/kg in anesthetized SHR. The present data show that stevioside given intravenously to conscious SHR was effective in blood pressure reduction and there was no change in serum catecholamines in anaesthetized animals with this natural compound.",
keywords = "Blood pressure, Plasma catecholamines, Spontaneously hypertensive rat, Stevioside",
author = "Paul Chan and Xu, {De Yi} and Liu, {Ju Chi} and Chen, {Yi Jen} and Brian Tomlinson and Huang, {Wen Pin} and Cheng, {Juei Tang}",
year = "1998",
month = "10",
day = "2",
doi = "10.1016/S0024-3205(98)00439-1",
language = "English",
volume = "63",
pages = "1679--1684",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "19",

}

TY - JOUR

T1 - The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats

AU - Chan, Paul

AU - Xu, De Yi

AU - Liu, Ju Chi

AU - Chen, Yi Jen

AU - Tomlinson, Brian

AU - Huang, Wen Pin

AU - Cheng, Juei Tang

PY - 1998/10/2

Y1 - 1998/10/2

N2 - Stevioside is a sweet-tasting glycoside, composed of stevia, a diterpenic carboxylic alcohol with three glucose molecules, mainly used as a substitute for non-alcoholic sweetener. It has previously been shown to reduce blood pressure in studies in animals and human. The effect of intravenous stevioside on the blood pressure was studied in spontaneously hypertensive rats (SHR). The hypotensive effect on both systolic and diastolic blood pressure was dose-dependent for intravenous doses of 50, 100 and 200 mg/kg in conscious SHR. The maximum reductions in systolic and diastolic blood pressure were 31.4 ± 4.2% and 40.8 ± 5.6% (mean ± SEM) respectively and the hypotensive effect lasted for more than 60 min with a dose of 200 mg/kg. Serum dopamine, norepinephrine and epinephrine levels were not changed significantly 60 min after intravenous injection of stevioside 100 mg/kg in anesthetized SHR. The present data show that stevioside given intravenously to conscious SHR was effective in blood pressure reduction and there was no change in serum catecholamines in anaesthetized animals with this natural compound.

AB - Stevioside is a sweet-tasting glycoside, composed of stevia, a diterpenic carboxylic alcohol with three glucose molecules, mainly used as a substitute for non-alcoholic sweetener. It has previously been shown to reduce blood pressure in studies in animals and human. The effect of intravenous stevioside on the blood pressure was studied in spontaneously hypertensive rats (SHR). The hypotensive effect on both systolic and diastolic blood pressure was dose-dependent for intravenous doses of 50, 100 and 200 mg/kg in conscious SHR. The maximum reductions in systolic and diastolic blood pressure were 31.4 ± 4.2% and 40.8 ± 5.6% (mean ± SEM) respectively and the hypotensive effect lasted for more than 60 min with a dose of 200 mg/kg. Serum dopamine, norepinephrine and epinephrine levels were not changed significantly 60 min after intravenous injection of stevioside 100 mg/kg in anesthetized SHR. The present data show that stevioside given intravenously to conscious SHR was effective in blood pressure reduction and there was no change in serum catecholamines in anaesthetized animals with this natural compound.

KW - Blood pressure

KW - Plasma catecholamines

KW - Spontaneously hypertensive rat

KW - Stevioside

UR - http://www.scopus.com/inward/record.url?scp=0032476163&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032476163&partnerID=8YFLogxK

U2 - 10.1016/S0024-3205(98)00439-1

DO - 10.1016/S0024-3205(98)00439-1

M3 - Article

VL - 63

SP - 1679

EP - 1684

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 19

ER -