The Effect of Photoluminescence of Bioceramic Irradiation on Middle Cerebral Arterial Occlusion in Rats

Lei Zhang, Paul Chan, Zhong Min Liu, Ling-Ling Hwang, Kuo Chi Lin, Wing P. Chan, Ting-Kai Leung, Cheuk-Sing Choy

Research output: Contribution to journalArticle

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Abstract

The purpose of this study is to determine the possible effect of photoluminescence of bioceramic (PLB) on ischemic cerebral infarction (stroke), by using an animal model of transient middle cerebral artery occlusion (MCAO). Sprague-Dawley rats were used to induce MCAO to block the origin of the left MCAO; three months later, the positive chronic stroke rats were selected by running tunnel maze; the MCAO rats with significant chronic stroke and neurological defects were used for treadmill experiments with varying speed settings to test their capability for restoration after muscular fatigue under conditions of with and without PLB irradiation. As a result, PLB irradiation could improve exercise completion rate and average running speed during slow and fast treadmill settings. After PLB irradiation, the selected MCAO rats successfully completed all the second-round treadmill exercises at the maximum speed setting, and they had better restoration from muscular fatigue. An in vitro cell study on astrocytes of rats by bioceramic irradiation further demonstrated increased intracellular nitric oxide. To explain these results, we suggest that cortical brain stimulation of microcirculation and enhancement of peripheral muscular activity are the main causes of the improved exercise performance in MCAO rats by PLB.

Original languageEnglish
Article number7230962
JournalEvidence-based Complementary and Alternative Medicine
Volume2016
DOIs
Publication statusPublished - 2016

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Middle Cerebral Artery Infarction
Muscle Fatigue
Stroke
Cerebral Infarction
Microcirculation
Astrocytes
Running
Sprague Dawley Rats
Nitric Oxide
Animal Models
Brain

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

The Effect of Photoluminescence of Bioceramic Irradiation on Middle Cerebral Arterial Occlusion in Rats. / Zhang, Lei; Chan, Paul; Liu, Zhong Min; Hwang, Ling-Ling; Lin, Kuo Chi; Chan, Wing P.; Leung, Ting-Kai; Choy, Cheuk-Sing.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2016, 7230962, 2016.

Research output: Contribution to journalArticle

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