The effect of mushroom beta-glucans from solid culture of ganoderma lucidum on inhibition of the primary tumor metastasis

Shiu Nan Chen, Ching Sheng Chang, Ming Hsin Hung, Sherwin Chen, William Wang, Cheng Jeng Tai, Chung Lun Lu

Research output: Contribution to journalArticle

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Abstract

This study evaluates the effect of mushroom beta-glucans (MBGS) derived from solid culture of Ganoderma lucidum on tumor inhibition by examining size of the primary tumor and rate of metastasis in Lewis lung carcinoma (LLC) bearing mice (C57BL/6), given oral administration of MBGS with radiation therapy. A previous result showed that MBGS enhances NK cell-mediated cytotoxicity in mice without LLC bearing in advance. Furthermore, applications of MBGS in conjunction with radiation therapy were effective in controlling tumor growth, and rate of metastasis, life threatening, and can potentially serve as a protective factor for wounds and hair loss that resulted from the overgrowth of primary tumor in LLC bearing mice.

Original languageEnglish
Article number252171
JournalEvidence-based Complementary and Alternative Medicine
Volume2014
DOIs
Publication statusPublished - 2014

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Reishi
beta-Glucans
Agaricales
Lewis Lung Carcinoma
Neoplasm Metastasis
Neoplasms
Radiotherapy
Alopecia
Inbred C57BL Mouse
Natural Killer Cells
Oral Administration
Wounds and Injuries
Growth

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

The effect of mushroom beta-glucans from solid culture of ganoderma lucidum on inhibition of the primary tumor metastasis. / Chen, Shiu Nan; Chang, Ching Sheng; Hung, Ming Hsin; Chen, Sherwin; Wang, William; Tai, Cheng Jeng; Lu, Chung Lun.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2014, 252171, 2014.

Research output: Contribution to journalArticle

Chen, Shiu Nan ; Chang, Ching Sheng ; Hung, Ming Hsin ; Chen, Sherwin ; Wang, William ; Tai, Cheng Jeng ; Lu, Chung Lun. / The effect of mushroom beta-glucans from solid culture of ganoderma lucidum on inhibition of the primary tumor metastasis. In: Evidence-based Complementary and Alternative Medicine. 2014 ; Vol. 2014.
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