The effect of moderate endurance training on cardioprotective molecule adaptations

Zong Yan Cai, Cheng Chen Hsu, Mei Chich Hsu, Mao Shung Huang, Chao Pin Yang, Yung Yu Tsai, Borcherng Su

Research output: Contribution to journalArticle

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Abstract

Purpose: This study aimed to investigate the effect of moderate endurance training on cardio-protective molecule adaptations, including marker of stem cell activation in the myocardium. Materials and Methods: Twenty-four Spra-gue-Dawley rats were randomly divided into a 4-wk exercise training (4WT) group, a 4-wk sedentary control (4WC) group, an 8-wk exercise training (8WT) group, and an 8-wk sedentary control (8WC) group (n=6 respectively). The training protocol consisted of treadmill running at 20 m/ min for 30 min on a 0% grade, for 3 days/wk. Immunohistochemistry staining coupled with image analysis, as expressed by mean optical density, was used for protein quantification.Results: The results indicated that the heat shock protein (HSP70) and stem cell marker, as evaluated by c-kit, were higher in 4WT than those in the 4WC and 8WT group (p <0.05), and the HSP70 content in the 8WT was higher than that of the 8WC group. In addition, 4WT and 8WT groups exhibited a significantly higher hepatocyte growth factor (HGF) and c-met content compared to their respective control counterparts (p

Original languageEnglish
Pages (from-to)1912-1920
Number of pages9
JournalHealthMED
Volume5
Issue number6 SUPPL. 1
Publication statusPublished - 2011

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Exercise
Control Groups
Stem Cells
HSP70 Heat-Shock Proteins
Hepatocyte Growth Factor
Running
Myocardium
Immunohistochemistry
Staining and Labeling
Proteins

Keywords

  • C-kit
  • C-met
  • HGF
  • HSP70

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cai, Z. Y., Hsu, C. C., Hsu, M. C., Huang, M. S., Yang, C. P., Tsai, Y. Y., & Su, B. (2011). The effect of moderate endurance training on cardioprotective molecule adaptations. HealthMED, 5(6 SUPPL. 1), 1912-1920.

The effect of moderate endurance training on cardioprotective molecule adaptations. / Cai, Zong Yan; Hsu, Cheng Chen; Hsu, Mei Chich; Huang, Mao Shung; Yang, Chao Pin; Tsai, Yung Yu; Su, Borcherng.

In: HealthMED, Vol. 5, No. 6 SUPPL. 1, 2011, p. 1912-1920.

Research output: Contribution to journalArticle

Cai, ZY, Hsu, CC, Hsu, MC, Huang, MS, Yang, CP, Tsai, YY & Su, B 2011, 'The effect of moderate endurance training on cardioprotective molecule adaptations', HealthMED, vol. 5, no. 6 SUPPL. 1, pp. 1912-1920.
Cai ZY, Hsu CC, Hsu MC, Huang MS, Yang CP, Tsai YY et al. The effect of moderate endurance training on cardioprotective molecule adaptations. HealthMED. 2011;5(6 SUPPL. 1):1912-1920.
Cai, Zong Yan ; Hsu, Cheng Chen ; Hsu, Mei Chich ; Huang, Mao Shung ; Yang, Chao Pin ; Tsai, Yung Yu ; Su, Borcherng. / The effect of moderate endurance training on cardioprotective molecule adaptations. In: HealthMED. 2011 ; Vol. 5, No. 6 SUPPL. 1. pp. 1912-1920.
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