The Effect of Ketoanalogues on Chronic Kidney Disease Deterioration: A Meta-Analysis

Albert Li, Hsiang Yen Lee, Yen Chung Lin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effects of ketoanalogues (KA) on chronic kidney disease (CKD) deterioration have not yet been fully confirmed. To strengthen the evidence of the role of KA in CKD, PubMed and Embase were searched for studies published through February 2019. Effect sizes from ten randomized control trials (RCTs) and two non-RCTs comprising a total of 951 patients were pooled and analyzed. A restricted protein diet supplemented with ketoanalogues (RPKA) was found to significantly delay the progression of CKD (p = 0.008), particularly in patients with an estimated glomerular filtration rate (eGFR) > 18 mL/min/1.73 m2 (p < 0.0001). No significant change in eGFR was found when comparing a very-low-protein diet and a low-protein diet (p = 0.10). In addition, compared with the placebo, RPKA did not cause malnutrition (albumin: p = 0.56; cholesterol: p = 0.50). Moreover, RPKA significantly decreased phosphorous levels (p = 0.001), increased calcium levels (p = 0.04), and decreased parathyroid hormone (PTH) levels (p = 0.05) in patients with eGFR < 18 mL/min/1.73 m2. In conclusion, RPKA could slow down the progression of CKD in patients with eGFR > 18 mL/min/1.73 m2 without causing malnutrition and reverse CKD-MBD in patients with eGFR < 18 mL/min/1.73 m2.

Original languageEnglish
JournalNutrients
Volume11
Issue number5
DOIs
Publication statusPublished - Apr 26 2019

Fingerprint

kidney diseases
Chronic Renal Insufficiency
meta-analysis
Meta-Analysis
deterioration
glomerular filtration rate
Glomerular Filtration Rate
Protein-Restricted Diet
PubMed
Malnutrition
malnutrition
dietary protein

Keywords

  • chronic kidney disease
  • estimated glomerular filtration rate
  • ketoanalogue
  • restricted protein diet

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

The Effect of Ketoanalogues on Chronic Kidney Disease Deterioration : A Meta-Analysis. / Li, Albert; Lee, Hsiang Yen; Lin, Yen Chung.

In: Nutrients, Vol. 11, No. 5, 26.04.2019.

Research output: Contribution to journalArticle

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