The effect of H2-receptor antagonist and proton pump inhibitor on microbial proliferation in the stomach

Kun Wang, Hwai Jeng Lin, Chin Lin Perng, Guan Ying Tseng, Kwok Woon Yu, Full Young Chang, Shou Dong Lee

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background/Aims: Intra-gastric bacterial proliferation is frequent in patients with hypochlohydria. However, status of gastric bacterial infection in patients receiving proton pump inhibitor or H2-receptor antagonist remains controversial. The purpose of this study was to investigate the microbial condition of the stomach in patients who received H 2-receptor antagonist or proton pump inhibitor. Methodology: Between November 2000 and January 2002, 102 patients were enrolled in this study. Of these, 52 did not receive any treatment (group I), 26 received H 2-receptor antagonist (group II), and 24 received proton pump inhibitor (group III). Ten mL of gastric juice were aspirated for culture during endoscopic examination. The aerobic and anaerobic bacterial and fungal cultures were performed immediately. A glass pH meter measured the pH of the gastric juice. Results: The intra-gastric pH was 2.91±2.06 (mean ± SD), 4.12±2.83, and 5.11±2.47 for groups I, II, and III, respectively (p=0.001 between groups I and III, p>0.05 between groups I and II, and groups II and III). The positive bacterial culture rates were 66.7% (16/24) in group III, 46.2% (12/26) in group II, and 28.8% (15/52) in group I (p=0.007 between groups III and I, p>0.05 between groups I and II, and groups II and III). The positive candidal culture rates were 12.5% (3/24) in group III, 11.5% (3/26) in group II, and 17.3% (9/52) in group I (p>0.05). Conclusions: Patients who received proton pump inhibitor had more acid suppression and intra-gastric bacterial infection than those of the control group. The intra-gastric candidal infection was not related to intra-gastric pH or anti-secretory medication in this study.

Original languageEnglish
Pages (from-to)1540-1543
Number of pages4
JournalHepato-Gastroenterology
Volume51
Issue number59
Publication statusPublished - Sep 2004
Externally publishedYes

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Histamine H2 Receptors
Proton Pump Inhibitors
Stomach
Gastric Juice
Bacterial Infections
Infection Control
Glass
Control Groups
Acids
Infection

Keywords

  • Bacteria
  • Candida
  • H-receptor antagonist
  • pH
  • Proton pump inhibitor

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Wang, K., Lin, H. J., Perng, C. L., Tseng, G. Y., Yu, K. W., Chang, F. Y., & Lee, S. D. (2004). The effect of H2-receptor antagonist and proton pump inhibitor on microbial proliferation in the stomach. Hepato-Gastroenterology, 51(59), 1540-1543.

The effect of H2-receptor antagonist and proton pump inhibitor on microbial proliferation in the stomach. / Wang, Kun; Lin, Hwai Jeng; Perng, Chin Lin; Tseng, Guan Ying; Yu, Kwok Woon; Chang, Full Young; Lee, Shou Dong.

In: Hepato-Gastroenterology, Vol. 51, No. 59, 09.2004, p. 1540-1543.

Research output: Contribution to journalArticle

Wang, K, Lin, HJ, Perng, CL, Tseng, GY, Yu, KW, Chang, FY & Lee, SD 2004, 'The effect of H2-receptor antagonist and proton pump inhibitor on microbial proliferation in the stomach', Hepato-Gastroenterology, vol. 51, no. 59, pp. 1540-1543.
Wang, Kun ; Lin, Hwai Jeng ; Perng, Chin Lin ; Tseng, Guan Ying ; Yu, Kwok Woon ; Chang, Full Young ; Lee, Shou Dong. / The effect of H2-receptor antagonist and proton pump inhibitor on microbial proliferation in the stomach. In: Hepato-Gastroenterology. 2004 ; Vol. 51, No. 59. pp. 1540-1543.
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abstract = "Background/Aims: Intra-gastric bacterial proliferation is frequent in patients with hypochlohydria. However, status of gastric bacterial infection in patients receiving proton pump inhibitor or H2-receptor antagonist remains controversial. The purpose of this study was to investigate the microbial condition of the stomach in patients who received H 2-receptor antagonist or proton pump inhibitor. Methodology: Between November 2000 and January 2002, 102 patients were enrolled in this study. Of these, 52 did not receive any treatment (group I), 26 received H 2-receptor antagonist (group II), and 24 received proton pump inhibitor (group III). Ten mL of gastric juice were aspirated for culture during endoscopic examination. The aerobic and anaerobic bacterial and fungal cultures were performed immediately. A glass pH meter measured the pH of the gastric juice. Results: The intra-gastric pH was 2.91±2.06 (mean ± SD), 4.12±2.83, and 5.11±2.47 for groups I, II, and III, respectively (p=0.001 between groups I and III, p>0.05 between groups I and II, and groups II and III). The positive bacterial culture rates were 66.7{\%} (16/24) in group III, 46.2{\%} (12/26) in group II, and 28.8{\%} (15/52) in group I (p=0.007 between groups III and I, p>0.05 between groups I and II, and groups II and III). The positive candidal culture rates were 12.5{\%} (3/24) in group III, 11.5{\%} (3/26) in group II, and 17.3{\%} (9/52) in group I (p>0.05). Conclusions: Patients who received proton pump inhibitor had more acid suppression and intra-gastric bacterial infection than those of the control group. The intra-gastric candidal infection was not related to intra-gastric pH or anti-secretory medication in this study.",
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AU - Lin, Hwai Jeng

AU - Perng, Chin Lin

AU - Tseng, Guan Ying

AU - Yu, Kwok Woon

AU - Chang, Full Young

AU - Lee, Shou Dong

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N2 - Background/Aims: Intra-gastric bacterial proliferation is frequent in patients with hypochlohydria. However, status of gastric bacterial infection in patients receiving proton pump inhibitor or H2-receptor antagonist remains controversial. The purpose of this study was to investigate the microbial condition of the stomach in patients who received H 2-receptor antagonist or proton pump inhibitor. Methodology: Between November 2000 and January 2002, 102 patients were enrolled in this study. Of these, 52 did not receive any treatment (group I), 26 received H 2-receptor antagonist (group II), and 24 received proton pump inhibitor (group III). Ten mL of gastric juice were aspirated for culture during endoscopic examination. The aerobic and anaerobic bacterial and fungal cultures were performed immediately. A glass pH meter measured the pH of the gastric juice. Results: The intra-gastric pH was 2.91±2.06 (mean ± SD), 4.12±2.83, and 5.11±2.47 for groups I, II, and III, respectively (p=0.001 between groups I and III, p>0.05 between groups I and II, and groups II and III). The positive bacterial culture rates were 66.7% (16/24) in group III, 46.2% (12/26) in group II, and 28.8% (15/52) in group I (p=0.007 between groups III and I, p>0.05 between groups I and II, and groups II and III). The positive candidal culture rates were 12.5% (3/24) in group III, 11.5% (3/26) in group II, and 17.3% (9/52) in group I (p>0.05). Conclusions: Patients who received proton pump inhibitor had more acid suppression and intra-gastric bacterial infection than those of the control group. The intra-gastric candidal infection was not related to intra-gastric pH or anti-secretory medication in this study.

AB - Background/Aims: Intra-gastric bacterial proliferation is frequent in patients with hypochlohydria. However, status of gastric bacterial infection in patients receiving proton pump inhibitor or H2-receptor antagonist remains controversial. The purpose of this study was to investigate the microbial condition of the stomach in patients who received H 2-receptor antagonist or proton pump inhibitor. Methodology: Between November 2000 and January 2002, 102 patients were enrolled in this study. Of these, 52 did not receive any treatment (group I), 26 received H 2-receptor antagonist (group II), and 24 received proton pump inhibitor (group III). Ten mL of gastric juice were aspirated for culture during endoscopic examination. The aerobic and anaerobic bacterial and fungal cultures were performed immediately. A glass pH meter measured the pH of the gastric juice. Results: The intra-gastric pH was 2.91±2.06 (mean ± SD), 4.12±2.83, and 5.11±2.47 for groups I, II, and III, respectively (p=0.001 between groups I and III, p>0.05 between groups I and II, and groups II and III). The positive bacterial culture rates were 66.7% (16/24) in group III, 46.2% (12/26) in group II, and 28.8% (15/52) in group I (p=0.007 between groups III and I, p>0.05 between groups I and II, and groups II and III). The positive candidal culture rates were 12.5% (3/24) in group III, 11.5% (3/26) in group II, and 17.3% (9/52) in group I (p>0.05). Conclusions: Patients who received proton pump inhibitor had more acid suppression and intra-gastric bacterial infection than those of the control group. The intra-gastric candidal infection was not related to intra-gastric pH or anti-secretory medication in this study.

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KW - Candida

KW - H-receptor antagonist

KW - pH

KW - Proton pump inhibitor

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