The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways

Kuo Han-Pin, Liu Shufang, Peter J. Barnes

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)

Abstract

We studied the effect of endogenous nitric oxide (NO) on vagally induced plasma exudation into guinea-pig trachea and main bronchi using 125I-albumin as a plasma marker. NG-Nitro-L-arginine methyl ester (L-NAME, 1-10 mg/kg) dose dependently inhibited neurogenic plasma exudation. Intravenous phenylephrine which simulated the vasopressor effect as L-NAME (10 mg/kg) was without effect. The effect of L-NAME (5 mg/kg) was reversed by L-arginine (50 mg/kg). These results suggest that endogenous NO may contribute to neurogenic inflammation in the airways.

Original languageEnglish
Pages (from-to)385-388
Number of pages4
JournalEuropean Journal of Pharmacology
Volume221
Issue number2-3
DOIs
Publication statusPublished - Oct 20 1992
Externally publishedYes

Keywords

  • Airways
  • NANC nerves
  • Neurogenic inflammation
  • Nitric oxide (NO)
  • Plasma exudation
  • Vagus nerve

ASJC Scopus subject areas

  • Pharmacology

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