The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways

Kuo Han-Pin, Liu Shufang, Peter J. Barnes

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

We studied the effect of endogenous nitric oxide (NO) on vagally induced plasma exudation into guinea-pig trachea and main bronchi using 125I-albumin as a plasma marker. NG-Nitro-L-arginine methyl ester (L-NAME, 1-10 mg/kg) dose dependently inhibited neurogenic plasma exudation. Intravenous phenylephrine which simulated the vasopressor effect as L-NAME (10 mg/kg) was without effect. The effect of L-NAME (5 mg/kg) was reversed by L-arginine (50 mg/kg). These results suggest that endogenous NO may contribute to neurogenic inflammation in the airways.

Original languageEnglish
Pages (from-to)385-388
Number of pages4
JournalEuropean Journal of Pharmacology
Volume221
Issue number2-3
DOIs
Publication statusPublished - Oct 20 1992
Externally publishedYes

Fingerprint

NG-Nitroarginine Methyl Ester
Nitric Oxide
Guinea Pigs
Neurogenic Inflammation
Phenylephrine
Bronchi
Trachea
Arginine
Albumins

Keywords

  • Airways
  • NANC nerves
  • Neurogenic inflammation
  • Nitric oxide (NO)
  • Plasma exudation
  • Vagus nerve

ASJC Scopus subject areas

  • Pharmacology

Cite this

The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways. / Han-Pin, Kuo; Shufang, Liu; Barnes, Peter J.

In: European Journal of Pharmacology, Vol. 221, No. 2-3, 20.10.1992, p. 385-388.

Research output: Contribution to journalArticle

@article{471721b040464f889147839efd24dfc6,
title = "The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways",
abstract = "We studied the effect of endogenous nitric oxide (NO) on vagally induced plasma exudation into guinea-pig trachea and main bronchi using 125I-albumin as a plasma marker. NG-Nitro-L-arginine methyl ester (L-NAME, 1-10 mg/kg) dose dependently inhibited neurogenic plasma exudation. Intravenous phenylephrine which simulated the vasopressor effect as L-NAME (10 mg/kg) was without effect. The effect of L-NAME (5 mg/kg) was reversed by L-arginine (50 mg/kg). These results suggest that endogenous NO may contribute to neurogenic inflammation in the airways.",
keywords = "Airways, NANC nerves, Neurogenic inflammation, Nitric oxide (NO), Plasma exudation, Vagus nerve",
author = "Kuo Han-Pin and Liu Shufang and Barnes, {Peter J.}",
year = "1992",
month = "10",
day = "20",
doi = "10.1016/0014-2999(92)90728-M",
language = "English",
volume = "221",
pages = "385--388",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "2-3",

}

TY - JOUR

T1 - The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways

AU - Han-Pin, Kuo

AU - Shufang, Liu

AU - Barnes, Peter J.

PY - 1992/10/20

Y1 - 1992/10/20

N2 - We studied the effect of endogenous nitric oxide (NO) on vagally induced plasma exudation into guinea-pig trachea and main bronchi using 125I-albumin as a plasma marker. NG-Nitro-L-arginine methyl ester (L-NAME, 1-10 mg/kg) dose dependently inhibited neurogenic plasma exudation. Intravenous phenylephrine which simulated the vasopressor effect as L-NAME (10 mg/kg) was without effect. The effect of L-NAME (5 mg/kg) was reversed by L-arginine (50 mg/kg). These results suggest that endogenous NO may contribute to neurogenic inflammation in the airways.

AB - We studied the effect of endogenous nitric oxide (NO) on vagally induced plasma exudation into guinea-pig trachea and main bronchi using 125I-albumin as a plasma marker. NG-Nitro-L-arginine methyl ester (L-NAME, 1-10 mg/kg) dose dependently inhibited neurogenic plasma exudation. Intravenous phenylephrine which simulated the vasopressor effect as L-NAME (10 mg/kg) was without effect. The effect of L-NAME (5 mg/kg) was reversed by L-arginine (50 mg/kg). These results suggest that endogenous NO may contribute to neurogenic inflammation in the airways.

KW - Airways

KW - NANC nerves

KW - Neurogenic inflammation

KW - Nitric oxide (NO)

KW - Plasma exudation

KW - Vagus nerve

UR - http://www.scopus.com/inward/record.url?scp=0026767580&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026767580&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(92)90728-M

DO - 10.1016/0014-2999(92)90728-M

M3 - Article

VL - 221

SP - 385

EP - 388

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2-3

ER -