The purpose of this study was to investigated that the effect of different hypoxic exposure duration on body weight and glucose tolerance. Methods: After one week adaptation in our animal resource center, eighteen male SD rats were matched the body weight and assigned into following three treatments: control (n=6), 1-hr hypoxia/day (n=6), and 8-hr hypoxia/day (n=6). All animals in treatment group were exposed to hypoxia for one week. Hypoxic treatment consisted of breathing 14% O2 under normobaric condition. An oral glucose tolerance test (OGTT) was performed 13h after last treatments. After OGTT, all animals were sacrificed to measure abdominal fat weight. Results: After one week intervention, 8-hr hypoxia/day not only significantly improved glucose tolerance but also decreased body weight and abdominal fat weight. Insulin response did not alter. Conclusion: hypoxia exposure improved glucose tolerance and reduced body weight. This result indicated hypoxia maybe an important role in the regulation of level of losses fat. The effect of the improvement maybe associated with the hypoxia duration and period.
|Original language||Traditional Chinese|
|Number of pages||5|
|Publication status||Published - 2007|
- abdominal fat weight
- fat loss