The effect of combined steroid and calcium channel blocker injection on human hypertrophic scars in animal model: A new strategy for the treatment of hypertrophic scars

Jui Yung Yang, Chun Yuan Huang

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background Hypertrophic scars (HScs) are inelastic scars that can cause functional loss and disfigurement. Decorin regulates collagen fibrillogenesis, and its expression is lower in HScs than in normal skin and during wound healing. Objective To evaluate the efficacy of combined verapamil and triamcinolone in treating HScs. Methods Excised human HSc fragments from surgically treated burned patients were divided into three groups: A (normal saline), B (verapamil), and C (verapamil and triamcinolone). The specimens were bilaterally implanted in the back of nude mice, treated using intralesional injections, and observed for 4 weeks. We compared the fibroblast viability and proliferation, decorin staining, and scar weights to evaluate treatment efficacy. Results Viability and proliferation of HSc fibroblasts from groups B and C were significantly lower at all time intervals after transplantation (p

Original languageEnglish
Pages (from-to)1942-1949
Number of pages8
JournalDermatologic Surgery
Volume36
Issue number12
DOIs
Publication statusPublished - Dec 2010

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Hypertrophic Cicatrix
Calcium Channel Blockers
Verapamil
Decorin
Triamcinolone
Animal Models
Steroids
Injections
Cicatrix
Fibroblasts
Intralesional Injections
Nude Mice
Wound Healing
Collagen
Therapeutics
Transplantation
Staining and Labeling
Weights and Measures
Skin

ASJC Scopus subject areas

  • Dermatology
  • Surgery

Cite this

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abstract = "Background Hypertrophic scars (HScs) are inelastic scars that can cause functional loss and disfigurement. Decorin regulates collagen fibrillogenesis, and its expression is lower in HScs than in normal skin and during wound healing. Objective To evaluate the efficacy of combined verapamil and triamcinolone in treating HScs. Methods Excised human HSc fragments from surgically treated burned patients were divided into three groups: A (normal saline), B (verapamil), and C (verapamil and triamcinolone). The specimens were bilaterally implanted in the back of nude mice, treated using intralesional injections, and observed for 4 weeks. We compared the fibroblast viability and proliferation, decorin staining, and scar weights to evaluate treatment efficacy. Results Viability and proliferation of HSc fibroblasts from groups B and C were significantly lower at all time intervals after transplantation (p",
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N2 - Background Hypertrophic scars (HScs) are inelastic scars that can cause functional loss and disfigurement. Decorin regulates collagen fibrillogenesis, and its expression is lower in HScs than in normal skin and during wound healing. Objective To evaluate the efficacy of combined verapamil and triamcinolone in treating HScs. Methods Excised human HSc fragments from surgically treated burned patients were divided into three groups: A (normal saline), B (verapamil), and C (verapamil and triamcinolone). The specimens were bilaterally implanted in the back of nude mice, treated using intralesional injections, and observed for 4 weeks. We compared the fibroblast viability and proliferation, decorin staining, and scar weights to evaluate treatment efficacy. Results Viability and proliferation of HSc fibroblasts from groups B and C were significantly lower at all time intervals after transplantation (p

AB - Background Hypertrophic scars (HScs) are inelastic scars that can cause functional loss and disfigurement. Decorin regulates collagen fibrillogenesis, and its expression is lower in HScs than in normal skin and during wound healing. Objective To evaluate the efficacy of combined verapamil and triamcinolone in treating HScs. Methods Excised human HSc fragments from surgically treated burned patients were divided into three groups: A (normal saline), B (verapamil), and C (verapamil and triamcinolone). The specimens were bilaterally implanted in the back of nude mice, treated using intralesional injections, and observed for 4 weeks. We compared the fibroblast viability and proliferation, decorin staining, and scar weights to evaluate treatment efficacy. Results Viability and proliferation of HSc fibroblasts from groups B and C were significantly lower at all time intervals after transplantation (p

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