The effect of botulinum toxin A in unilateral cleft lip scar: comparison of results with different sites of injection

T. C. Lu, K. Bhandari, C. F. Yao, P. K.T. Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Botulinum toxin type A (BTA) injections into the subjacent orbicularis oris muscle have been shown to improve appearance and produce narrower cheiloplasty scars. This study was performed to determine the effect of BTA injected at different sites on the unilateral cleft lip scar and cleft side nostril width. A double-blind, randomized prospective trial was conducted involving 64 consecutive patients with unilateral cleft lip undergoing primary cheiloplasty between September 2016 and January 2019. The patients were randomized to receive BTA injections either into the subjacent orbicularis oris muscle (4 points group) or into the bilateral nasolabial fold region (6 points group) during cheiloplasty. The scars were assessed by photographic scar width measurements and Vancouver scar scale assessment tool. The cleft side nostril width was compared to the non-cleft side width. Fifty-six patients completed the trial, 24 in the 4 points group and 31 in the 6 points group. There was no significant difference in scar width or nostril width measurements between the groups at the end of follow-up. The Vancouver scar scale assessment was also similar between the groups. There was no significant difference in scar width or nostril width measurements after cleft lip repair between patients treated with botulinum toxin injections to the subjacent orbicularis oris muscle and patients treated with injections in the nasolabial region.

Original languageEnglish
Pages (from-to)900-905
Number of pages6
JournalInternational Journal of Oral and Maxillofacial Surgery
Volume51
Issue number7
DOIs
Publication statusPublished - Jul 2022

Keywords

  • botulinum toxin type A
  • cicatrix
  • cleft lip
  • facial muscles
  • nasolabial fold

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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