The distribution of interleukin-19 in healthy and neoplastic tissue

Chung Hsi Hsing, Hsing Hui Li, Yu Hsiang Hsu, Chung Liang Ho, Shih Sung Chuang, Kuo Mao Lan, Ming Shi Chang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The influence of interleukin (IL)-19, a recently discovered cytokine in the IL-10 family, on tissue is still unclear. Our aim was to determine the distribution of IL-19 expression and to delineate the cell types that express IL-19 in healthy and neoplastic tissue, because this information will significantly facilitate the exploration of its pathophysiological functions. We used tissue microarray technology and an immunohistochemical survey with an anti-IL-19 monoclonal antibody to examine the expression of IL-19 in 28 healthy and 15 neoplastic tissues. IL-19 protein was positively stained in 15 healthy tissue types and three major cell types: epithelial cells, endothelial cells, and macrophages. We also found that several types of tumor cells were positively stained for IL-19, especially in squamous cell carcinoma (SCC) of the skin, tongue, esophagus, and lung. SCC of the oral cavity expressed IL-19 mRNA and its receptors. In two cell lines derived from SCC of oral cavity tumor tissue, IL-19 specifically activated an intracellular signal and induced proliferation of the cells, which indicated that IL-19 may act in an autocrine manner in SCC tumors. This study provides important references for further investigation of the biological functions and clinical implications of IL-19 in humans.

Original languageEnglish
Pages (from-to)221-228
Number of pages8
JournalCytokine
Volume44
Issue number2
DOIs
Publication statusPublished - Nov 2008

Fingerprint

Interleukins
Tissue
Squamous Cell Carcinoma
Tumors
Mouth
Cells
Neoplasms
Macrophages
Endothelial cells
Microarrays
Tongue
Interleukin-10
Esophagus
Skin
Endothelial Cells
Epithelial Cells
Monoclonal Antibodies
Cell Proliferation
Cytokines
Technology

Keywords

  • Cytokines
  • Interleukin-19
  • Tissue microarray

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Biochemistry
  • Molecular Biology

Cite this

Hsing, C. H., Li, H. H., Hsu, Y. H., Ho, C. L., Chuang, S. S., Lan, K. M., & Chang, M. S. (2008). The distribution of interleukin-19 in healthy and neoplastic tissue. Cytokine, 44(2), 221-228. https://doi.org/10.1016/j.cyto.2008.06.007

The distribution of interleukin-19 in healthy and neoplastic tissue. / Hsing, Chung Hsi; Li, Hsing Hui; Hsu, Yu Hsiang; Ho, Chung Liang; Chuang, Shih Sung; Lan, Kuo Mao; Chang, Ming Shi.

In: Cytokine, Vol. 44, No. 2, 11.2008, p. 221-228.

Research output: Contribution to journalArticle

Hsing, CH, Li, HH, Hsu, YH, Ho, CL, Chuang, SS, Lan, KM & Chang, MS 2008, 'The distribution of interleukin-19 in healthy and neoplastic tissue', Cytokine, vol. 44, no. 2, pp. 221-228. https://doi.org/10.1016/j.cyto.2008.06.007
Hsing CH, Li HH, Hsu YH, Ho CL, Chuang SS, Lan KM et al. The distribution of interleukin-19 in healthy and neoplastic tissue. Cytokine. 2008 Nov;44(2):221-228. https://doi.org/10.1016/j.cyto.2008.06.007
Hsing, Chung Hsi ; Li, Hsing Hui ; Hsu, Yu Hsiang ; Ho, Chung Liang ; Chuang, Shih Sung ; Lan, Kuo Mao ; Chang, Ming Shi. / The distribution of interleukin-19 in healthy and neoplastic tissue. In: Cytokine. 2008 ; Vol. 44, No. 2. pp. 221-228.
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