The distribution of interleukin-19 in healthy and neoplastic tissue

Chung Hsi Hsing, Hsing Hui Li, Yu Hsiang Hsu, Chung Liang Ho, Shih Sung Chuang, Kuo Mao Lan, Ming Shi Chang

Research output: Contribution to journalArticle

23 Citations (Scopus)


The influence of interleukin (IL)-19, a recently discovered cytokine in the IL-10 family, on tissue is still unclear. Our aim was to determine the distribution of IL-19 expression and to delineate the cell types that express IL-19 in healthy and neoplastic tissue, because this information will significantly facilitate the exploration of its pathophysiological functions. We used tissue microarray technology and an immunohistochemical survey with an anti-IL-19 monoclonal antibody to examine the expression of IL-19 in 28 healthy and 15 neoplastic tissues. IL-19 protein was positively stained in 15 healthy tissue types and three major cell types: epithelial cells, endothelial cells, and macrophages. We also found that several types of tumor cells were positively stained for IL-19, especially in squamous cell carcinoma (SCC) of the skin, tongue, esophagus, and lung. SCC of the oral cavity expressed IL-19 mRNA and its receptors. In two cell lines derived from SCC of oral cavity tumor tissue, IL-19 specifically activated an intracellular signal and induced proliferation of the cells, which indicated that IL-19 may act in an autocrine manner in SCC tumors. This study provides important references for further investigation of the biological functions and clinical implications of IL-19 in humans.

Original languageEnglish
Pages (from-to)221-228
Number of pages8
Issue number2
Publication statusPublished - Nov 2008


  • Cytokines
  • Interleukin-19
  • Tissue microarray

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Biochemistry
  • Molecular Biology

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  • Cite this

    Hsing, C. H., Li, H. H., Hsu, Y. H., Ho, C. L., Chuang, S. S., Lan, K. M., & Chang, M. S. (2008). The distribution of interleukin-19 in healthy and neoplastic tissue. Cytokine, 44(2), 221-228.