The diagnostic accuracy of 256-row computed tomographic angiography compared with invasive coronary angiography in patients with suspected coronary artery disease

Shu Ping Chao, Wai Yip Law, Chu Jen Kuo, Huei Fong Hung, Jun Jack Cheng, Huey Ming Lo, Kou Gi Shyu

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Aims To assess the diagnostic accuracy of 256-row computed tomographic angiography (CTA) in patients with suspected coronary artery disease (CAD). Non-invasive imaging of the coronary artery by CTA has increasingly been used in recent years. The accuracy of 256-row CTA has not yet been studied. We sought to assess the accuracy of 256-row CTA compared with invasive coronary angiography (ICA) in the diagnosis and assessment of CAD. Methods and resultsWe prospectively evaluated 104 consecutive individuals who accepted CTA and then underwent ICA. The presence of stenosis ≥50 was considered obstructive. The diagnostic accuracy of CTA for detecting obstructive stenosis was compared with that of ICA. The area under the receiver-operating-characteristic curve (AUC) was used to evaluate the diagnostic accuracy of CTA relative to ICA. A total of 86 patients had obstructive CAD. The patient-based analysis of CTA for detecting stenosis ≥50 according to ICA revealed an AUC of 0.744 [95 confidence interval (CI), 0.572-0.916], with a sensitivity of 98.8, a specificity of 50, a positive predictive value (PPV) of 92.4, and a negative predictive value (NPV) of 87.5. The segment-based analysis revealed an AUC of 0.915 (95 CI, 0.847-0.982), with a sensitivity of 93.5, a specificity of 95, a PPV of 77.6, and an NPV of 98.7. The vessel-based analysis revealed an AUC of 0.887 (95 CI, 0.808-0.966), with a sensitivity of 94.3, a specificity of 87.3, a PPV of 82.7, and an NPV of 95.9. Conclusion 256-Row CTA is a highly sensitive test of CAD and has a high predictive value. 256-Row CTA may be a potential alternative to detect coronary artery stenosis and rule out CAD in suspected patients.

Original languageEnglish
Pages (from-to)1916-1923
Number of pages8
JournalEuropean Heart Journal
Volume31
Issue number15
DOIs
Publication statusPublished - Aug 2010

Fingerprint

Coronary Angiography
Coronary Artery Disease
Angiography
Area Under Curve
Pathologic Constriction
Confidence Intervals
Coronary Stenosis
ROC Curve
Coronary Vessels

Keywords

  • 256-Row computed tomography
  • Computed tomographic angiography
  • Invasive coronary angiography
  • Multi-detector computed tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The diagnostic accuracy of 256-row computed tomographic angiography compared with invasive coronary angiography in patients with suspected coronary artery disease. / Chao, Shu Ping; Law, Wai Yip; Kuo, Chu Jen; Hung, Huei Fong; Cheng, Jun Jack; Lo, Huey Ming; Shyu, Kou Gi.

In: European Heart Journal, Vol. 31, No. 15, 08.2010, p. 1916-1923.

Research output: Contribution to journalArticle

Chao, Shu Ping ; Law, Wai Yip ; Kuo, Chu Jen ; Hung, Huei Fong ; Cheng, Jun Jack ; Lo, Huey Ming ; Shyu, Kou Gi. / The diagnostic accuracy of 256-row computed tomographic angiography compared with invasive coronary angiography in patients with suspected coronary artery disease. In: European Heart Journal. 2010 ; Vol. 31, No. 15. pp. 1916-1923.
@article{fb31a4ef66c94377affce0a2b03cab0f,
title = "The diagnostic accuracy of 256-row computed tomographic angiography compared with invasive coronary angiography in patients with suspected coronary artery disease",
abstract = "Aims To assess the diagnostic accuracy of 256-row computed tomographic angiography (CTA) in patients with suspected coronary artery disease (CAD). Non-invasive imaging of the coronary artery by CTA has increasingly been used in recent years. The accuracy of 256-row CTA has not yet been studied. We sought to assess the accuracy of 256-row CTA compared with invasive coronary angiography (ICA) in the diagnosis and assessment of CAD. Methods and resultsWe prospectively evaluated 104 consecutive individuals who accepted CTA and then underwent ICA. The presence of stenosis ≥50 was considered obstructive. The diagnostic accuracy of CTA for detecting obstructive stenosis was compared with that of ICA. The area under the receiver-operating-characteristic curve (AUC) was used to evaluate the diagnostic accuracy of CTA relative to ICA. A total of 86 patients had obstructive CAD. The patient-based analysis of CTA for detecting stenosis ≥50 according to ICA revealed an AUC of 0.744 [95 confidence interval (CI), 0.572-0.916], with a sensitivity of 98.8, a specificity of 50, a positive predictive value (PPV) of 92.4, and a negative predictive value (NPV) of 87.5. The segment-based analysis revealed an AUC of 0.915 (95 CI, 0.847-0.982), with a sensitivity of 93.5, a specificity of 95, a PPV of 77.6, and an NPV of 98.7. The vessel-based analysis revealed an AUC of 0.887 (95 CI, 0.808-0.966), with a sensitivity of 94.3, a specificity of 87.3, a PPV of 82.7, and an NPV of 95.9. Conclusion 256-Row CTA is a highly sensitive test of CAD and has a high predictive value. 256-Row CTA may be a potential alternative to detect coronary artery stenosis and rule out CAD in suspected patients.",
keywords = "256-Row computed tomography, Computed tomographic angiography, Invasive coronary angiography, Multi-detector computed tomography",
author = "Chao, {Shu Ping} and Law, {Wai Yip} and Kuo, {Chu Jen} and Hung, {Huei Fong} and Cheng, {Jun Jack} and Lo, {Huey Ming} and Shyu, {Kou Gi}",
year = "2010",
month = "8",
doi = "10.1093/eurheartj/ehq072",
language = "English",
volume = "31",
pages = "1916--1923",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "15",

}

TY - JOUR

T1 - The diagnostic accuracy of 256-row computed tomographic angiography compared with invasive coronary angiography in patients with suspected coronary artery disease

AU - Chao, Shu Ping

AU - Law, Wai Yip

AU - Kuo, Chu Jen

AU - Hung, Huei Fong

AU - Cheng, Jun Jack

AU - Lo, Huey Ming

AU - Shyu, Kou Gi

PY - 2010/8

Y1 - 2010/8

N2 - Aims To assess the diagnostic accuracy of 256-row computed tomographic angiography (CTA) in patients with suspected coronary artery disease (CAD). Non-invasive imaging of the coronary artery by CTA has increasingly been used in recent years. The accuracy of 256-row CTA has not yet been studied. We sought to assess the accuracy of 256-row CTA compared with invasive coronary angiography (ICA) in the diagnosis and assessment of CAD. Methods and resultsWe prospectively evaluated 104 consecutive individuals who accepted CTA and then underwent ICA. The presence of stenosis ≥50 was considered obstructive. The diagnostic accuracy of CTA for detecting obstructive stenosis was compared with that of ICA. The area under the receiver-operating-characteristic curve (AUC) was used to evaluate the diagnostic accuracy of CTA relative to ICA. A total of 86 patients had obstructive CAD. The patient-based analysis of CTA for detecting stenosis ≥50 according to ICA revealed an AUC of 0.744 [95 confidence interval (CI), 0.572-0.916], with a sensitivity of 98.8, a specificity of 50, a positive predictive value (PPV) of 92.4, and a negative predictive value (NPV) of 87.5. The segment-based analysis revealed an AUC of 0.915 (95 CI, 0.847-0.982), with a sensitivity of 93.5, a specificity of 95, a PPV of 77.6, and an NPV of 98.7. The vessel-based analysis revealed an AUC of 0.887 (95 CI, 0.808-0.966), with a sensitivity of 94.3, a specificity of 87.3, a PPV of 82.7, and an NPV of 95.9. Conclusion 256-Row CTA is a highly sensitive test of CAD and has a high predictive value. 256-Row CTA may be a potential alternative to detect coronary artery stenosis and rule out CAD in suspected patients.

AB - Aims To assess the diagnostic accuracy of 256-row computed tomographic angiography (CTA) in patients with suspected coronary artery disease (CAD). Non-invasive imaging of the coronary artery by CTA has increasingly been used in recent years. The accuracy of 256-row CTA has not yet been studied. We sought to assess the accuracy of 256-row CTA compared with invasive coronary angiography (ICA) in the diagnosis and assessment of CAD. Methods and resultsWe prospectively evaluated 104 consecutive individuals who accepted CTA and then underwent ICA. The presence of stenosis ≥50 was considered obstructive. The diagnostic accuracy of CTA for detecting obstructive stenosis was compared with that of ICA. The area under the receiver-operating-characteristic curve (AUC) was used to evaluate the diagnostic accuracy of CTA relative to ICA. A total of 86 patients had obstructive CAD. The patient-based analysis of CTA for detecting stenosis ≥50 according to ICA revealed an AUC of 0.744 [95 confidence interval (CI), 0.572-0.916], with a sensitivity of 98.8, a specificity of 50, a positive predictive value (PPV) of 92.4, and a negative predictive value (NPV) of 87.5. The segment-based analysis revealed an AUC of 0.915 (95 CI, 0.847-0.982), with a sensitivity of 93.5, a specificity of 95, a PPV of 77.6, and an NPV of 98.7. The vessel-based analysis revealed an AUC of 0.887 (95 CI, 0.808-0.966), with a sensitivity of 94.3, a specificity of 87.3, a PPV of 82.7, and an NPV of 95.9. Conclusion 256-Row CTA is a highly sensitive test of CAD and has a high predictive value. 256-Row CTA may be a potential alternative to detect coronary artery stenosis and rule out CAD in suspected patients.

KW - 256-Row computed tomography

KW - Computed tomographic angiography

KW - Invasive coronary angiography

KW - Multi-detector computed tomography

UR - http://www.scopus.com/inward/record.url?scp=77953498744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953498744&partnerID=8YFLogxK

U2 - 10.1093/eurheartj/ehq072

DO - 10.1093/eurheartj/ehq072

M3 - Article

C2 - 20233790

AN - SCOPUS:77953498744

VL - 31

SP - 1916

EP - 1923

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 15

ER -