The development of a nanocrystalline apatite reinforced crosslinked hyaluronic acid-N,O-carboxymethylchitosan (NOCC) composite as an injectable bone cement

Fwu Long Mi, Shu Huei Yu, Deh Wei Tang, Hao Ying Hsieh, Tzu Hung Kuo, Wei Ren Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, a water-soluble chitosan derivative, N,O- carboxymethylchitosan (NOCC) has been synthesized. Hyaluronic acid (HA) could evolve into a better cross-linked hydrogel by conjugating with NOCC, using carbodiimide as a cross-linker, therefore decreased the swelling capability and increased the resistance against hyaluronidase degradation of the HA-based hydrogels. The NOCC/HA mixed solution, after reacting with carbodiimide, increased its viscosity instantously and formed a hydrogel having a relatively low degree of swelling and high resistance against hyaluronidase. An injectable bone cement composed of nanocrystalline hydroxyapatite (HAp) and crosslinked NOCC/HA were developed by directly blending apatites with the NOCC/HA mixed solution, followed by crosslinked with carbodiimide. The mechanical strength of the NOCC/HA hydrogels were tuned by varying the apatite loading and NOCC/HA mixed ratio. These results indicated that the nanocrystalline HAp reinforced NOCC/HA composites make them attractive for as an injectable bone cement.

Original languageEnglish
Title of host publication7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010
PublisherACCM-7 Organizing Committee
Pages967-970
Number of pages4
Volume2
ISBN (Print)9781632660756
Publication statusPublished - 2010
Externally publishedYes
Event7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010 - Taipei, Taiwan
Duration: Nov 15 2010Nov 18 2010

Other

Other7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010
CountryTaiwan
CityTaipei
Period11/15/1011/18/10

Fingerprint

Hyaluronic acid
Apatites
Bone cement
Bone Cements
Apatite
Hyaluronic Acid
Composite materials
Carbodiimides
Hydrogels
Hyaluronoglucosaminidase
Hydrogel
Durapatite
Hydroxyapatite
Swelling
O-carboxymethylchitosan
Chitosan
Strength of materials
Viscosity
Derivatives
Degradation

Keywords

  • Chitosan
  • Hyaluronic acid
  • Hydroxyapatite
  • Thermal stability

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials

Cite this

Mi, F. L., Yu, S. H., Tang, D. W., Hsieh, H. Y., Kuo, T. H., & Wang, W. R. (2010). The development of a nanocrystalline apatite reinforced crosslinked hyaluronic acid-N,O-carboxymethylchitosan (NOCC) composite as an injectable bone cement. In 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010 (Vol. 2, pp. 967-970). ACCM-7 Organizing Committee.

The development of a nanocrystalline apatite reinforced crosslinked hyaluronic acid-N,O-carboxymethylchitosan (NOCC) composite as an injectable bone cement. / Mi, Fwu Long; Yu, Shu Huei; Tang, Deh Wei; Hsieh, Hao Ying; Kuo, Tzu Hung; Wang, Wei Ren.

7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010. Vol. 2 ACCM-7 Organizing Committee, 2010. p. 967-970.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mi, FL, Yu, SH, Tang, DW, Hsieh, HY, Kuo, TH & Wang, WR 2010, The development of a nanocrystalline apatite reinforced crosslinked hyaluronic acid-N,O-carboxymethylchitosan (NOCC) composite as an injectable bone cement. in 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010. vol. 2, ACCM-7 Organizing Committee, pp. 967-970, 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010, Taipei, Taiwan, 11/15/10.
Mi FL, Yu SH, Tang DW, Hsieh HY, Kuo TH, Wang WR. The development of a nanocrystalline apatite reinforced crosslinked hyaluronic acid-N,O-carboxymethylchitosan (NOCC) composite as an injectable bone cement. In 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010. Vol. 2. ACCM-7 Organizing Committee. 2010. p. 967-970
Mi, Fwu Long ; Yu, Shu Huei ; Tang, Deh Wei ; Hsieh, Hao Ying ; Kuo, Tzu Hung ; Wang, Wei Ren. / The development of a nanocrystalline apatite reinforced crosslinked hyaluronic acid-N,O-carboxymethylchitosan (NOCC) composite as an injectable bone cement. 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010. Vol. 2 ACCM-7 Organizing Committee, 2010. pp. 967-970
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