The development of a nanocrystalline apatite reinforced crosslinked hyaluronic acid-N,O-carboxymethylchitosan (NOCC) composite as an injectable bone cement

Fwu Long Mi, Shu Huei Yu, Deh Wei Tang, Hao Ying Hsieh, Tzu Hung Kuo, Wei Ren Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, a water-soluble chitosan derivative, N,O- carboxymethylchitosan (NOCC) has been synthesized. Hyaluronic acid (HA) could evolve into a better cross-linked hydrogel by conjugating with NOCC, using carbodiimide as a cross-linker, therefore decreased the swelling capability and increased the resistance against hyaluronidase degradation of the HA-based hydrogels. The NOCC/HA mixed solution, after reacting with carbodiimide, increased its viscosity instantously and formed a hydrogel having a relatively low degree of swelling and high resistance against hyaluronidase. An injectable bone cement composed of nanocrystalline hydroxyapatite (HAp) and crosslinked NOCC/HA were developed by directly blending apatites with the NOCC/HA mixed solution, followed by crosslinked with carbodiimide. The mechanical strength of the NOCC/HA hydrogels were tuned by varying the apatite loading and NOCC/HA mixed ratio. These results indicated that the nanocrystalline HAp reinforced NOCC/HA composites make them attractive for as an injectable bone cement.

Original languageEnglish
Title of host publication7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010
PublisherACCM-7 Organizing Committee
Pages967-970
Number of pages4
Volume2
ISBN (Print)9781632660756
Publication statusPublished - 2010
Externally publishedYes
Event7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010 - Taipei, Taiwan
Duration: Nov 15 2010Nov 18 2010

Other

Other7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010
CountryTaiwan
CityTaipei
Period11/15/1011/18/10

Keywords

  • Chitosan
  • Hyaluronic acid
  • Hydroxyapatite
  • Thermal stability

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials

Fingerprint Dive into the research topics of 'The development of a nanocrystalline apatite reinforced crosslinked hyaluronic acid-N,O-carboxymethylchitosan (NOCC) composite as an injectable bone cement'. Together they form a unique fingerprint.

  • Cite this

    Mi, F. L., Yu, S. H., Tang, D. W., Hsieh, H. Y., Kuo, T. H., & Wang, W. R. (2010). The development of a nanocrystalline apatite reinforced crosslinked hyaluronic acid-N,O-carboxymethylchitosan (NOCC) composite as an injectable bone cement. In 7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010 (Vol. 2, pp. 967-970). ACCM-7 Organizing Committee.