The Descriptive study of dietary and serum Vitamin B12 among subjects with type 2 diabetes on metformin therapy in a regional teaching hospital in middle Taiwan

Chih Hsuan Lin, Wen Pin Chang, Der Yan Tai, Shwu Huey Yang

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Metformin has been considered the first choice of oral antidiabetic drugs (OADs) for typo 2 diabetes melitus (T2DM) patients. It has been proposed that Metformin could reduce Vitamin B12 absorption since 1971. Vitamin B12 is one of the essential nutrients for body and human cells growth, red blood cells formation and maintains epithelium and neuron myelin function. The symptoms of Vitamin B12 deficiency Include precious anemia and nervous system disorders, such as neuropathy, spinal cord lesions, and memory disorders. We observed whether Metformin treatment for T2DM patients with adequate Vitamin B12 intake may cause serum Vitamin B12 deficiency or not. This was a cross-sectional study and recruited T2DM subjects aged from 20-85 yrs., excluded patients of vegetarians, postgastrotomy, and taking vitamin supplements more than thrice a week regularly. We collected medicaJ history and blood data, dietary information by 24 hours dietary recalls and food frequency questionnaire (FFQ). TotaJ 200 subjects were recruited in this study, Vitamin B12 Intake was 1.8 ± 1.7 μg/day by 24- hour dietary recalls, 3.7 ± 2.6 μg/day by FFQ, serum Vitamin B12 levels was 493.6 ± 318.3 pg/ml. There were strong correlations between 24 hours and FFQ (p < 0.000) in Vitamin Bl2 intake, but no correlation between dietary Vitamin B12and serum Vitamin B12 (p > 0.05). No significant correlation existed among Metformin dosage and dietary Vitamin B12, blood Vitamin B12 level. No serum Vitamin B12 deficiency existed when Metformin treatment forT2DM patients with adequate Vitamin B12 intake in a Taiwan regional teaching hospital.

Original languageEnglish
Pages (from-to)344-352
Number of pages9
JournalJournal of Internal Medicine of Taiwan
Issue number6
Publication statusPublished - Dec 1 2015


ASJC Scopus subject areas

  • Internal Medicine

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