The degree of early life stress predicts decreased medial prefrontal activations and the shift from internally to externally guided decision making: An exploratory NIRS study during resting state and self-oriented task

Takashi Nakao, Tomoya Matsumoto, Machiko Morita, Daisuke Shimizu, Shinpei Yoshimura, Georg Northoff, Shigeru Morinobu, Yasumasa Okamoto, Shigeto Yamawaki

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Early life stress (ELS), an important risk factor for psychopathology in mental disorders, is associated neuronally with decreased functional connectivity within the default mode network (DMN) in the resting state. Moreover, it is linked with greater deactivation in DMN during a working memory task. Although DMN shows large amplitudes of very-low-frequency oscillations (VLFO) and strong involvement during self-oriented tasks, these features' relation to ELS remains unclear. Therefore, our preliminary study investigated the relationship between ELS and the degree of frontal activations during a resting state and self-oriented task using near infrared spectroscopy (NIRS). From 22 healthy participants, regional hemodynamic changes in 43 front-temporal channels were recorded during 5 min resting states, and execution of a self-oriented task (color-preference judgment) and a control task (color-similarity judgment). Using a child abuse and trauma scale (CATS), ELS was quantified. We observed that ELS showed a negative correlation with medial prefrontal cortex (MPFC) activation during both resting state and color-preference judgment. In contrast, no significant correlation was found between ELS and MPFC activation during color-similarity judgment. Additionally, we observed that ELS and the MPFC activation during color-preference judgment were associated behaviorally with the rate of similar color choice in preference judgment, which suggests that, for participants with higher ELS, decisions in the color-preference judgment were based on an external criterion (color similarity) rather than an internal criterion (subjective preference). Taken together, our neuronal and behavioral findings show that high ELS is related to lower MPFC activation during both rest and self-oriented tasks. This is behaviorally manifest in an abnormal shift from internally to externally guided decision-making, even under circumstances where internal guidance is required.

Original languageEnglish
JournalFrontiers in Human Neuroscience
Issue numberJUN
DOIs
Publication statusPublished - Jun 16 2013
Externally publishedYes

Fingerprint

Near-Infrared Spectroscopy
Psychological Stress
Decision Making
Color
Prefrontal Cortex
Child Abuse
Psychopathology
Short-Term Memory
Mental Disorders
Healthy Volunteers
Hemodynamics
Wounds and Injuries

Keywords

  • Cortisol
  • Eyes closed resting state
  • Internally guided decision making
  • Lateral prefrontal cortex (LPFC)
  • Mediation analysis
  • Moderation analysis
  • Task positive network (TPN)
  • Very low frequency fluctuations

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neurology
  • Biological Psychiatry
  • Behavioral Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

The degree of early life stress predicts decreased medial prefrontal activations and the shift from internally to externally guided decision making : An exploratory NIRS study during resting state and self-oriented task. / Nakao, Takashi; Matsumoto, Tomoya; Morita, Machiko; Shimizu, Daisuke; Yoshimura, Shinpei; Northoff, Georg; Morinobu, Shigeru; Okamoto, Yasumasa; Yamawaki, Shigeto.

In: Frontiers in Human Neuroscience, No. JUN, 16.06.2013.

Research output: Contribution to journalArticle

Nakao, Takashi ; Matsumoto, Tomoya ; Morita, Machiko ; Shimizu, Daisuke ; Yoshimura, Shinpei ; Northoff, Georg ; Morinobu, Shigeru ; Okamoto, Yasumasa ; Yamawaki, Shigeto. / The degree of early life stress predicts decreased medial prefrontal activations and the shift from internally to externally guided decision making : An exploratory NIRS study during resting state and self-oriented task. In: Frontiers in Human Neuroscience. 2013 ; No. JUN.
@article{ca18e3c528a7449d8e9769511c3b9289,
title = "The degree of early life stress predicts decreased medial prefrontal activations and the shift from internally to externally guided decision making: An exploratory NIRS study during resting state and self-oriented task",
abstract = "Early life stress (ELS), an important risk factor for psychopathology in mental disorders, is associated neuronally with decreased functional connectivity within the default mode network (DMN) in the resting state. Moreover, it is linked with greater deactivation in DMN during a working memory task. Although DMN shows large amplitudes of very-low-frequency oscillations (VLFO) and strong involvement during self-oriented tasks, these features' relation to ELS remains unclear. Therefore, our preliminary study investigated the relationship between ELS and the degree of frontal activations during a resting state and self-oriented task using near infrared spectroscopy (NIRS). From 22 healthy participants, regional hemodynamic changes in 43 front-temporal channels were recorded during 5 min resting states, and execution of a self-oriented task (color-preference judgment) and a control task (color-similarity judgment). Using a child abuse and trauma scale (CATS), ELS was quantified. We observed that ELS showed a negative correlation with medial prefrontal cortex (MPFC) activation during both resting state and color-preference judgment. In contrast, no significant correlation was found between ELS and MPFC activation during color-similarity judgment. Additionally, we observed that ELS and the MPFC activation during color-preference judgment were associated behaviorally with the rate of similar color choice in preference judgment, which suggests that, for participants with higher ELS, decisions in the color-preference judgment were based on an external criterion (color similarity) rather than an internal criterion (subjective preference). Taken together, our neuronal and behavioral findings show that high ELS is related to lower MPFC activation during both rest and self-oriented tasks. This is behaviorally manifest in an abnormal shift from internally to externally guided decision-making, even under circumstances where internal guidance is required.",
keywords = "Cortisol, Eyes closed resting state, Internally guided decision making, Lateral prefrontal cortex (LPFC), Mediation analysis, Moderation analysis, Task positive network (TPN), Very low frequency fluctuations",
author = "Takashi Nakao and Tomoya Matsumoto and Machiko Morita and Daisuke Shimizu and Shinpei Yoshimura and Georg Northoff and Shigeru Morinobu and Yasumasa Okamoto and Shigeto Yamawaki",
year = "2013",
month = "6",
day = "16",
doi = "10.3389/fnhum.2013.00339",
language = "English",
journal = "Frontiers in Neuroscience",
issn = "1662-4548",
publisher = "Frontiers Research Foundation",
number = "JUN",

}

TY - JOUR

T1 - The degree of early life stress predicts decreased medial prefrontal activations and the shift from internally to externally guided decision making

T2 - An exploratory NIRS study during resting state and self-oriented task

AU - Nakao, Takashi

AU - Matsumoto, Tomoya

AU - Morita, Machiko

AU - Shimizu, Daisuke

AU - Yoshimura, Shinpei

AU - Northoff, Georg

AU - Morinobu, Shigeru

AU - Okamoto, Yasumasa

AU - Yamawaki, Shigeto

PY - 2013/6/16

Y1 - 2013/6/16

N2 - Early life stress (ELS), an important risk factor for psychopathology in mental disorders, is associated neuronally with decreased functional connectivity within the default mode network (DMN) in the resting state. Moreover, it is linked with greater deactivation in DMN during a working memory task. Although DMN shows large amplitudes of very-low-frequency oscillations (VLFO) and strong involvement during self-oriented tasks, these features' relation to ELS remains unclear. Therefore, our preliminary study investigated the relationship between ELS and the degree of frontal activations during a resting state and self-oriented task using near infrared spectroscopy (NIRS). From 22 healthy participants, regional hemodynamic changes in 43 front-temporal channels were recorded during 5 min resting states, and execution of a self-oriented task (color-preference judgment) and a control task (color-similarity judgment). Using a child abuse and trauma scale (CATS), ELS was quantified. We observed that ELS showed a negative correlation with medial prefrontal cortex (MPFC) activation during both resting state and color-preference judgment. In contrast, no significant correlation was found between ELS and MPFC activation during color-similarity judgment. Additionally, we observed that ELS and the MPFC activation during color-preference judgment were associated behaviorally with the rate of similar color choice in preference judgment, which suggests that, for participants with higher ELS, decisions in the color-preference judgment were based on an external criterion (color similarity) rather than an internal criterion (subjective preference). Taken together, our neuronal and behavioral findings show that high ELS is related to lower MPFC activation during both rest and self-oriented tasks. This is behaviorally manifest in an abnormal shift from internally to externally guided decision-making, even under circumstances where internal guidance is required.

AB - Early life stress (ELS), an important risk factor for psychopathology in mental disorders, is associated neuronally with decreased functional connectivity within the default mode network (DMN) in the resting state. Moreover, it is linked with greater deactivation in DMN during a working memory task. Although DMN shows large amplitudes of very-low-frequency oscillations (VLFO) and strong involvement during self-oriented tasks, these features' relation to ELS remains unclear. Therefore, our preliminary study investigated the relationship between ELS and the degree of frontal activations during a resting state and self-oriented task using near infrared spectroscopy (NIRS). From 22 healthy participants, regional hemodynamic changes in 43 front-temporal channels were recorded during 5 min resting states, and execution of a self-oriented task (color-preference judgment) and a control task (color-similarity judgment). Using a child abuse and trauma scale (CATS), ELS was quantified. We observed that ELS showed a negative correlation with medial prefrontal cortex (MPFC) activation during both resting state and color-preference judgment. In contrast, no significant correlation was found between ELS and MPFC activation during color-similarity judgment. Additionally, we observed that ELS and the MPFC activation during color-preference judgment were associated behaviorally with the rate of similar color choice in preference judgment, which suggests that, for participants with higher ELS, decisions in the color-preference judgment were based on an external criterion (color similarity) rather than an internal criterion (subjective preference). Taken together, our neuronal and behavioral findings show that high ELS is related to lower MPFC activation during both rest and self-oriented tasks. This is behaviorally manifest in an abnormal shift from internally to externally guided decision-making, even under circumstances where internal guidance is required.

KW - Cortisol

KW - Eyes closed resting state

KW - Internally guided decision making

KW - Lateral prefrontal cortex (LPFC)

KW - Mediation analysis

KW - Moderation analysis

KW - Task positive network (TPN)

KW - Very low frequency fluctuations

UR - http://www.scopus.com/inward/record.url?scp=84933680069&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84933680069&partnerID=8YFLogxK

U2 - 10.3389/fnhum.2013.00339

DO - 10.3389/fnhum.2013.00339

M3 - Article

AN - SCOPUS:84933680069

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

SN - 1662-4548

IS - JUN

ER -